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MEROPS

Recommended

General Information

The MEROPS database is an information resource for peptidases (also termed proteases, proteinases and proteolytic enzymes) and the proteins that inhibit them.

Homepage http://www.ebi.ac.uk/merops/

Countries that developed this resource United Kingdom

Created in 1996

Taxonomic range

All

Knowledge Domains

Subjects

In the following recommendations:

How to cite this record FAIRsharing.org: MEROPS; MEROPS; DOI: https://doi.org/10.25504/FAIRsharing.2s4n8r; Last edited: April 26, 2021, 2:59 p.m.; Last accessed: Aug 02 2021 1:06 a.m.

Record updated: April 16, 2021, 11:20 a.m. by The FAIRsharing Team.

Show edit history

Edits to 'https://fairsharing.org/FAIRsharing.2s4n8r' by 'The FAIRsharing Team' at 11:20, 16 Apr 2021 (approved):

	'organizations' has been modified:
		Before:
			The Wellcome Trust, UK|https://wellcome.ac.uk/|Funds
			European Commission under FP7 Grant Agreement|http://ec.europa.eu/research/fp7/index_en.cfm?pg=documents|Undefined
			EMBL-EBI Industry Programme, EMBL-EBI, Wellcome Genome Campus, Hinxton, Cambridgeshire, UK|http://www.ebi.ac.uk/industry|Maintains
			Biotechnology and Biological Sciences Research Council (BBSRC), UK|https://bbsrc.ukri.org|Funds
			National Science Foundation (NSF), USA|https://www.nsf.gov/|Funds
		After:
			The Wellcome Trust, UK|https://wellcome.ac.uk/|Funds
			Biotechnology and Biological Sciences Research Council (BBSRC), UK|https://bbsrc.ukri.org|Funds
			National Science Foundation (NSF), USA|https://www.nsf.gov/|Funds
			EMBL-EBI Industry Programme, EMBL-EBI, Wellcome Genome Campus, Hinxton, Cambridgeshire, UK|http://www.ebi.ac.uk/industry|Maintains
			European Commission under FP7 Grant Agreement|http://ec.europa.eu/research/fp7/index_en.cfm?pg=documents|Funds
		Added:
			European Commission under FP7 Grant Agreement|http://ec.europa.eu/research/fp7/index_en.cfm?pg=documents|Funds
		Removed:
			European Commission under FP7 Grant Agreement|http://ec.europa.eu/research/fp7/index_en.cfm?pg=documents|Undefined

Edits to 'https://fairsharing.org/FAIRsharing.2s4n8r' by 'The FAIRsharing Team' at 09:36, 03 Mar 2021 (approved):

	'organizations' has been modified:
		Before:
			European Commission under FP7 Grant Agreement|http://ec.europa.eu/research/fp7/index_en.cfm?pg=documents|Undefined
			The Wellcome Trust, UK|https://wellcome.ac.uk/|Funds
			The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge, UK|http://www.sanger.ac.uk|Maintains
		After:
			The Wellcome Trust, UK|https://wellcome.ac.uk/|Funds
			European Commission under FP7 Grant Agreement|http://ec.europa.eu/research/fp7/index_en.cfm?pg=documents|Undefined
			EMBL-EBI Industry Programme, EMBL-EBI, Wellcome Genome Campus, Hinxton, Cambridgeshire, UK|http://www.ebi.ac.uk/industry|Maintains
			Biotechnology and Biological Sciences Research Council (BBSRC), UK|https://bbsrc.ukri.org|Funds
			National Science Foundation (NSF), USA|https://www.nsf.gov/|Funds
		Added:
			EMBL-EBI Industry Programme, EMBL-EBI, Wellcome Genome Campus, Hinxton, Cambridgeshire, UK|http://www.ebi.ac.uk/industry|Maintains
			Biotechnology and Biological Sciences Research Council (BBSRC), UK|https://bbsrc.ukri.org|Funds
			National Science Foundation (NSF), USA|https://www.nsf.gov/|Funds
		Removed:
			The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge, UK|http://www.sanger.ac.uk|Maintains

	'supportLinks' has been modified:
		Before:
			blog|http://meropsdb.wordpress.com
			help|http://merops.sanger.ac.uk/about/index.shtml
			help|http://merops.sanger.ac.uk/about/classification.shtml
		After:
			blog|http://meropsdb.wordpress.com
			help|https://www.ebi.ac.uk/merops/about/index.shtml
		Added:
			help|https://www.ebi.ac.uk/merops/about/index.shtml
		Removed:
			help|http://merops.sanger.ac.uk/about/index.shtml
			help|http://merops.sanger.ac.uk/about/classification.shtml

	'tools' has been modified:
		Before:
			BLAST||http://merops.sanger.ac.uk/cgi-bin/batch_blast
			BLAST||http://merops.sanger.ac.uk/cgi-bin/blast/submitblast/merops/advanced
		After:
		Added:
		Removed:
			BLAST||http://merops.sanger.ac.uk/cgi-bin/batch_blast
			BLAST||http://merops.sanger.ac.uk/cgi-bin/blast/submitblast/merops/advanced

	'onto_domains' has been modified:
		Before:
			DNA sequence
			Nucleic acid sequence
			Protein domain
			Protein structure
			Proteolytic digest
			enzyme
			polypeptide_region
			protease_site
			protein
			structure
		After:
			DNA sequence
			Nucleic acid sequence
			Protein domain
			Protein structure
			Proteolytic digest
			Structure
			enzyme
			polypeptide_region
			protease_site
			protein
			structure
		Added:
			Structure
		Removed:

	'contactEmail' has been modified:
		Before: merops@sanger.ac.uk
		After: merops@ebi.ac.uk

	'grants' has been modified:
		Before:
		After:
			1458808
			BB/N00521X/1
			WT077044/Z/05/Z
			WT098051
		Added:
			1458808
			BB/N00521X/1
			WT077044/Z/05/Z
			WT098051
		Removed:

	'publications' has been modified:
		Before:
			Evolutionary families of peptidases.|Rawlings ND,Barrett AJ|Biochem J|1993
			MEROPS: the peptidase database.|Rawlings ND,Barrett AJ|Nucleic Acids Res|1998
			MEROPS: the database of proteolytic enzymes, their substrates and inhibitors.|Rawlings ND,Barrett AJ,Bateman A|Nucleic Acids Res|2011
			Twenty years of the MEROPS database of proteolytic enzymes, their substrates and inhibitors.|Rawlings ND,Barrett AJ,Finn R|Nucleic Acids Res|2015
			Peptidase specificity from the substrate cleavage collection in the MEROPS database and a tool to measure cleavage site conservation.|Rawlings ND|Biochimie|2015
			MEROPS: the peptidase database.|Rawlings ND., Morton FR., Kok CY., Kong J., Barrett AJ., |Nucleic Acids Res.|2008
		After:
			Evolutionary families of peptidases.|Rawlings ND,Barrett AJ|Biochem J|1993
			MEROPS: the peptidase database.|Rawlings ND,Barrett AJ|Nucleic Acids Res|1998
			MEROPS: the database of proteolytic enzymes, their substrates and inhibitors.|Rawlings ND,Barrett AJ,Bateman A|Nucleic Acids Res|2011
			Twenty years of the MEROPS database of proteolytic enzymes, their substrates and inhibitors.|Rawlings ND,Barrett AJ,Finn R|Nucleic Acids Res|2015
			Peptidase specificity from the substrate cleavage collection in the MEROPS database and a tool to measure cleavage site conservation.|Rawlings ND|Biochimie|2015
			MEROPS: the peptidase database.|Rawlings ND., Morton FR., Kok CY., Kong J., Barrett AJ., |Nucleic Acids Res.|2008
			The MEROPS database of proteolytic enzymes, their substrates and inhibitors in 2017 and a comparison with peptidases in the PANTHER database.|Rawlings ND,Barrett AJ,Thomas PD,Huang X,Bateman A,Finn RD|Nucleic Acids Res|2017
		Added:
			The MEROPS database of proteolytic enzymes, their substrates and inhibitors in 2017 and a comparison with peptidases in the PANTHER database.|Rawlings ND,Barrett AJ,Thomas PD,Huang X,Bateman A,Finn RD|Nucleic Acids Res|2017
		Removed:

	'dataProcesses' has been modified:
		Before:
			Download, data access, http://merops.sanger.ac.uk/download_list.shtml
			submit, data access, http://merops.sanger.ac.uk/submissions.shtml
		After:
			Download, data access, https://www.ebi.ac.uk/merops/download_list.shtml
			None, data release, https://www.ebi.ac.uk/merops/whatsnew.shtml
			BLAST, data access, https://www.ebi.ac.uk/merops/submit_searches.shtml
			Search, data access, https://www.ebi.ac.uk/merops/search.shtml
			Submit, data curation, https://www.ebi.ac.uk/merops/submissions.shtml
		Added:
			Download, data access, https://www.ebi.ac.uk/merops/download_list.shtml
			None, data release, https://www.ebi.ac.uk/merops/whatsnew.shtml
			BLAST, data access, https://www.ebi.ac.uk/merops/submit_searches.shtml
			Search, data access, https://www.ebi.ac.uk/merops/search.shtml
			Submit, data curation, https://www.ebi.ac.uk/merops/submissions.shtml
		Removed:
			Download, data access, http://merops.sanger.ac.uk/download_list.shtml
			submit, data access, http://merops.sanger.ac.uk/submissions.shtml

	'homepage' has been modified:
		Before: http://merops.sanger.ac.uk/
		After: http://www.ebi.ac.uk/merops/

Edits to 'https://fairsharing.org/FAIRsharing.2s4n8r' by 'The FAIRsharing Team' at 10:52, 21 Nov 2018 (approved):

	'domains' has been modified:
		Before:
			Amino acid sequence
			Biomedical Science
			Enzyme
			Life Science
			Nucleic acid sequence
			Protease site
			Protein
			Protein domain
			Protein structure
			Proteolytic digest
			Structure
		After:
			Amino acid sequence
			Biomedical Science
			DNA sequence data
			Enzyme
			Life Science
			Nucleic acid sequence
			Protease site
			Protein
			Protein domain
			Protein structure
			Proteolytic digest
			Structure
		Added:
			DNA sequence data
		Removed:

Edits to 'https://fairsharing.org/FAIRsharing.2s4n8r' by 'The FAIRsharing Team' at 23:37, 19 Dec 2016 (approved):

	'name' has been modified:
		Before: MEROPS - the Peptidase Database
		After: MEROPS

In Collections

RDA Covid-19 WG Resources

Support

General

blog	http://meropsdb.wordpress.com
help	https://www.ebi.ac.uk/merops/about/index ...

Additional Information

Contact

General Contact

Tools

No tools defined

Access / Retrieve Data

Conditions of Use

Applies to: General

GNU General Public License (GPL) 3.0

Data Release

None	https://www.ebi.ac.uk/merops/whatsnew.shtml

Data Curation

Submit

https://www.ebi.ac.uk/merops/submissions.shtml

Data Access

Download	https://www.ebi.ac.uk/merops/download_list.shtml
BLAST	https://www.ebi.ac.uk/merops/submit_searches.shtml
Search	https://www.ebi.ac.uk/merops/search.shtml

Publications

Evolutionary families of peptidases.

Rawlings ND,Barrett AJ
Biochem J 1993

View Paper (PubMed)

MEROPS: the peptidase database.

Rawlings ND,Barrett AJ
Nucleic Acids Res 1998

View Paper (PubMed)

MEROPS: the database of proteolytic enzymes, their substrates and inhibitors.

Rawlings ND,Barrett AJ,Bateman A
Nucleic Acids Res 2011

View Paper (PubMed) View Publication

Twenty years of the MEROPS database of proteolytic enzymes, their substrates and inhibitors.

Rawlings ND,Barrett AJ,Finn R
Nucleic Acids Res 2015

View Paper (PubMed) View Publication

Peptidase specificity from the substrate cleavage collection in the MEROPS database and a tool to measure cleavage site conservation.

Rawlings ND
Biochimie 2015

View Paper (PubMed) View Publication

MEROPS: the peptidase database.

Rawlings ND., Morton FR., Kok CY., Kong J., Barrett AJ.,
Nucleic Acids Res. 2008

View Paper (PubMed)

The MEROPS database of proteolytic enzymes, their substrates and inhibitors in 2017 and a comparison with peptidases in the PANTHER database.

Rawlings ND,Barrett AJ,Thomas PD,Huang X,Bateman A,Finn RD
Nucleic Acids Res 2017

View Paper (PubMed) View Publication

Related Standards

Reporting Guidelines

No guidelines defined

Terminology Artifacts

No semantic standards defined

Models and Formats

FASTA Sequence Format

Identifier Schemas

No identifier schema standards defined

Metrics

No metrics standards defined

Related Databases

Termini-Oriented Protein Function INferred Database

Implementing Policies

Credit

Record Maintainer

This record is in need of a maintainer. If you login, you'll be able to claim this record.

Funds

The Wellcome Trust, UK (Charitable foundation)
Biotechnology and Biological Sciences Research Council (BBSRC), UK (Government body)
National Science Foundation (NSF), USA (Government body)
European Commission under FP7 Grant Agreement (Government body)

Maintains

EMBL-EBI Industry Programme, EMBL-EBI, Wellcome Genome Campus, Hinxton, Cambridgeshire, UK (Government body)

Grant Number(s)

1458808 (National Science Foundation (NSF), USA)
BB/N00521X/1 (Biotechnology and Biological Sciences Research Council (BBSRC), UK)
WT077044/Z/05/Z (The Wellcome Trust, UK)
WT098051 (The Wellcome Trust, UK)

MEROPS

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