standards > terminology artifact > DOI:10.25504/FAIRsharing.4dvtcz

ready Cell Line Ontology

Abbreviation: CLO

General Information
The Cell Line Ontology (CLO) is a community-driven ontology that is developed to standardize and integrate cell line information and support computer-assisted reasoning. Thousands of cell lines have been artificially developed and used for different applications. Information about cell lines is typically stored in public repositories and indexed catalogues. Most cell lines are commercially available. Some cell lines are only transferred between academic laboratories. Information about cell lines has not been well standardized and machine-readable to date. Integration of data from multiple sources is a challenge, confounded by lack of consistent naming conventions, contamination of cell lines, and provision of the same cell lines by multiple commercial sources but with different biological attributes. The Cell Line Ontology (CLO) is a community-based effort to represent all cell lines in a starndard ontology approach.

How to cite this record CLO; Cell Line Ontology; DOI:; Last edited: Jan. 8, 2019, 1:35 p.m.; Last accessed: Jan 24 2019 7:14 a.m.

Record updated: Sept. 9, 2016, 2:50 p.m. by The FAIRsharing Team.


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CLO: The cell line ontology.

Sarntivijai S,Lin Y,Xiang Z,Meehan TF,Diehl AD,Vempati UD,Schurer SC,Pang C,Malone J,Parkinson H,Liu Y,Takatsuki T,Saijo K,Masuya H,Nakamura Y,Brush MH,Haendel MA,Zheng J,Stoeckert CJ,Peters B,Mungall CJ,Carey TE,States DJ,Athey BD,He Y
J Biomed Semantics 2014

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Implementing Databases (2)
ENCODE Project
The ENCODE (Encyclopedia of DNA Elements) Consortium is an international collaboration of research groups funded by the National Human Genome Research Institute (NHGRI). The goal of ENCODE is to build a comprehensive parts list of functional elements in the human genome, including elements that act at the protein and RNA levels, and regulatory elements that control cells and circumstances in which a gene is active. ENCODE results from 2007 and later are available from this project. This covers data generated during the two production phases 2007-2012 and 2013-present.

OBO Foundry
The Open Biological and Biomedical Ontology (OBO) Foundry is a collective of ontology developers that are committed to collaboration and adherence to shared principles. The mission of the OBO Foundry is to develop a family of interoperable ontologies that are both logically well-formed and scientifically accurate. To achieve this, OBO Foundry participants voluntarily adhere to and contribute to the development of an evolving set of principles including open use, collaborative development, non-overlapping and strictly-scoped content, and common syntax and relations, based on ontology models that work well, such as the Gene Ontology (GO). The OBO Foundry is overseen by an Operations Committee with Editorial, Technical and Outreach working groups.

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Grant Number(s)

  • 1R01GM093132-01 (National Institutes of Health (NIH), Bethesda, MD, USA)

  • 1R24OD011883 (National Institutes of Health (NIH), Bethesda, MD, USA)

  • 200754 Gen2Phen (Cordis)

  • U54 DA021519 (National Center for Integrative Biomedical Informatics (NCBCS), Ann Arbor, MI, USA)

  • grants 1R01AI081062 (YH) (Bioinformatics Resource Centers, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD, USA)