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ready PRotein Ontology

Abbreviation: PRO

General Information
Protein Ontology (PRO) provides an ontological representation of protein-related entities by explicitly defining them and showing the relationships between them. Each PRO term represents a distinct class of entities (including specific modified forms, orthologous isoforms, and protein complexes) ranging from the taxon-neutral to the taxon-specific. The ontology has a meta-structure encompassing three areas: proteins based on evolutionary relatedness (ProEvo); protein forms produced from a given gene locus (ProForm); and protein-containing complexes (ProComp).

How to cite this record PRO; PRotein Ontology; DOI:; Last edited: Jan. 29, 2020, 2:23 p.m.; Last accessed: Jan 18 2022 7:05 a.m.

Publication for citation  Protein Ontology (PRO): enhancing and scaling up the representation of protein entities. Natale DA,Arighi CN,Blake JA,Bona J,Chen C,Chen SC,Christie KR,Cowart J,D'Eustachio P,Diehl AD,Drabkin HJ,Duncan WD,Huang H,Ren J,Ross K,Ruttenberg A,Shamovsky V,Smith B,Wang Q,Zhang J,El-Sayed A,Wu CH; Nucleic Acids Res ; 2016; 10.1093/nar/gkw1075;

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Record updated: Jan. 29, 2020, 2:23 p.m. by The FAIRsharing Team.

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The representation of protein complexes in the Protein Ontology (PRO).

Bult CJ,Drabkin HJ,Evsikov A,Natale D,Arighi C,Roberts N,Ruttenberg A,D'Eustachio P,Smith B,Blake JA,Wu C
BMC Bioinformatics 2011

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Framework for a protein ontology.

Natale DA,Arighi CN,Barker WC,Blake J,Chang TC,Hu Z,Liu H,Smith B,Wu CH
BMC Bioinformatics 2007

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The Protein Ontology: a structured representation of protein forms and complexes.

Natale DA,Arighi CN,Barker WC,Blake JA,Bult CJ,Caudy M,Drabkin HJ,D'Eustachio P,Evsikov AV,Huang H,Nchoutmboube J,Roberts NV,Smith B,Zhang J,Wu CH
Nucleic Acids Res 2011

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Protein Ontology: a controlled structured network of protein entities.

Natale DA,Arighi CN,Blake JA,Bult CJ,Christie KR,Cowart J,D'Eustachio P,Diehl AD,Drabkin HJ,Helfer O,Huang H,Masci AM,Ren J,Roberts NV,Ross K,Ruttenberg A,Shamovsky V,Smith B,Yerramalla MS,Zhang J,AlJanahi A,Celen I,Gan C,Lv M,Schuster-Lezell E,Wu CH
Nucleic Acids Res 2014

View Paper (PubMed) View Publication

Protein Ontology (PRO): enhancing and scaling up the representation of protein entities.

Natale DA,Arighi CN,Blake JA,Bona J,Chen C,Chen SC,Christie KR,Cowart J,D'Eustachio P,Diehl AD,Drabkin HJ,Duncan WD,Huang H,Ren J,Ross K,Ruttenberg A,Shamovsky V,Smith B,Wang Q,Zhang J,El-Sayed A,Wu CH
Nucleic Acids Res 2016

View Paper (PubMed) View Publication

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  • This record is maintained by dnatale



Grant Number(s)

  • 1UL1TR001412 (National Center for Advancing Translational Sciences (NCATS), Bethesda, MD, USA)

  • DBI-1062520 (National Science Foundation (NSF), USA)

  • HHSN272201200028C (National Institute of Allergy and Infectious Diseases (NIAD), Bethesda, MD, USA)

  • R01GM080646 (National Institutes of Health (NIH), Bethesda, MD, USA)