TDR Targets

General Information

Identification and ranking of targets and bioactive compounds against neglected tropical diseases. TDR Targets integrates chemical and genomic information and allows users to prioritize targets and compounds to develop and repurpose new drugs and chemical tools for human pathogens. The TDR Target Project was started in 2005 after a call for applications was launched by TDR (Special Programme for Research and Training in Tropical Diseases (UNICEF / UNDP / World Bank / WHO, http://www.who.int/tdr)). As a result, the TDR Targets Database was established to help develop a portfolio of candidate drug targets for 5 major human pathogens. This shortly turned into a resource for prioritizing targets for neglected tropical diseases. TDR Targets is led and run by the Trypanosomatics group at IIB-UNSAM (Argentina, https://trypanosomatics.org) with help with external collaborators worldwide.

Homepage https://tdrtargets.org

Countries that developed this resource Argentina

Created in 2007

Taxonomic range

Brugia malayi

Chlamydia trachomatis

Echinococcus granulosus

Echinococcus multilocularis

Entamoeba histolytica

Mycobacterium tuberculosis

Mycobacterium ulcerans

Onchocerca volvulus

Plasmodium falciparum

Trichomonas vaginalis

Trypanosoma brucei

Trypanosoma cruzi

Wolbachia (Brugia malayi)

Knowledge Domains

Subjects

User-defined Tags

Atomic composition

Drug-like compound

Number of flexible bonds

Rule of five compliance

How to cite this record FAIRsharing.org: TDR Targets; TDR Targets; DOI: https://doi.org/10.25504/FAIRsharing.6c4fvf; Last edited: Oct. 22, 2019, 11:07 a.m.; Last accessed: Nov 22 2019 10:17 a.m.

This record is maintained by fernan ORCID

Record updated: Oct. 21, 2019, 3:34 p.m. by fernan.

Show edit history

Edits to 'https://fairsharing.org/FAIRsharing.6c4fvf' by 'fernan' at 15:34, 21 Oct 2019 (approved):

	'organizations' has been modified:
		Before:
			University of Washington, USA|https://www.washington.edu/|Maintains
		After:
			University of Washington, USA|https://www.washington.edu/|Undefined
			Instituto de Investigaciones Biotecnolgicas, Universidad de San Martn - CONICET|http://www.iib.unsam.edu.ar/|Maintains
			World Health Organization, Special Programme for Research and Training in Tropical Diseases (WHO/TDR)|https://who.int/tdr|Funds
			Agencia Nacional de Promocin Cientfica (ANPCyT, Argentina)|https://www.argentina.gob.ar/ciencia/agencia|Funds
		Added:
			University of Washington, USA|https://www.washington.edu/|Undefined
			Instituto de Investigaciones Biotecnolgicas, Universidad de San Martn - CONICET|http://www.iib.unsam.edu.ar/|Maintains
			World Health Organization, Special Programme for Research and Training in Tropical Diseases (WHO/TDR)|https://who.int/tdr|Funds
			Agencia Nacional de Promocin Cientfica (ANPCyT, Argentina)|https://www.argentina.gob.ar/ciencia/agencia|Funds
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			University of Washington, USA|https://www.washington.edu/|Maintains

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			FAQ|http://tdrtargets.org/faq
			email|tdr-targetgroup@sanger.ac.uk
			online documentation|http://tdrtargets.org/documentation
			wikipedia|https://en.wikipedia.org/wiki/TDR_Targets
		After:
			FAQ|http://tdrtargets.org/faq
			email|info@tdrtargets.org
			online documentation|http://tdrtargets.org/documentation
			wikipedia|https://en.wikipedia.org/wiki/TDR_Targets
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			email|info@tdrtargets.org
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			email|tdr-targetgroup@sanger.ac.uk

	'description' has been modified:
		Before: Identification and ranking of targets against neglected tropical diseases
		After: Identification and ranking of targets and bioactive compounds against neglected tropical diseases. TDR Targets integrates chemical and genomic information and allows users to prioritize targets and compounds to develop and repurpose new drugs and chemical tools for human pathogens. 

The TDR Target Project was started in 2005 after a call for applications was launched by TDR (Special Programme for Research and Training in Tropical Diseases (UNICEF / UNDP / World Bank / WHO, http://www.who.int/tdr)). As a result, the TDR Targets Database was established to help develop a portfolio of candidate drug targets for 5 major human pathogens. This shortly turned into a resource for prioritizing targets for neglected tropical diseases. TDR Targets is led and run by the Trypanosomatics group at IIB-UNSAM (Argentina, https://trypanosomatics.org) with help with external collaborators worldwide.


	'countries' has been modified:
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			United Kingdom
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			Argentina
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			Argentina
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			United Kingdom

	'onto_domains' has been modified:
		Before:
			Annotation
			DNA sequence
			EC number
			GO-term enrichment report
			Gene expression data
			Gene name
			Genome annotation
			Pathway or network prediction
			Sequence length
			acceptor
			antigen
			bioactivity assay
			chemical descriptor
			disease
			donor
			gene
			glycosylphosphatidylinositol anchor
			logP descriptor
			molecular weight
			proton
			signal_peptide
			structure
		After:
			Annotation
			DNA sequence
			EC number
			GO-term enrichment report
			Gene expression data
			Gene name
			Genome annotation
			Pathway or network prediction
			Sequence length
			acceptor
			antigen
			bioactivity assay
			chemical descriptor
			chemical entity
			disease
			donor
			gene
			glycosylphosphatidylinositol anchor
			logP descriptor
			molecular weight
			proton
			signal_peptide
			structure
		Added:
			chemical entity
		Removed:

	'grants' has been modified:
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			A50830|
			PICT-2010-1479
			PICT-Glaxo-2013-0067
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			A50830|
			PICT-2010-1479
			PICT-Glaxo-2013-0067
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	'taxonomies' has been modified:
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			Brugia malayi
			Leishmania major
			Schistosoma mansoni
			Toxoplasma gondii
		After:
			Brugia malayi
			Chlamydia trachomatis
			Echinococcus granulosus
			Echinococcus multilocularis
			Entamoeba histolytica
			Giardia lamblia
			Leishmania major
			Loa Loa
			Mycobacterium leprae
			Mycobacterium tuberculosis
			Mycobacterium ulcerans
			Onchocerca volvulus
			Plasmodium falciparum
			Plasmodium vivax
			Schistosoma mansoni
			Toxoplasma gondii
			Treponema pallidum
			Trichomonas vaginalis
			Trypanosoma brucei
			Trypanosoma cruzi
			Wolbachia (Brugia malayi)
		Added:
			Chlamydia trachomatis
			Echinococcus granulosus
			Echinococcus multilocularis
			Entamoeba histolytica
			Giardia lamblia
			Loa Loa
			Mycobacterium leprae
			Mycobacterium tuberculosis
			Mycobacterium ulcerans
			Onchocerca volvulus
			Plasmodium falciparum
			Plasmodium vivax
			Treponema pallidum
			Trichomonas vaginalis
			Trypanosoma brucei
			Trypanosoma cruzi
			Wolbachia (Brugia malayi)
		Removed:

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		Before: http://tdrtargets.org
		After: https://tdrtargets.org

	'contactORCID' has been modified:
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		After: 0000-0003-1331-5741

Edits to 'https://fairsharing.org/FAIRsharing.6c4fvf' by 'The FAIRsharing Team' at 10:57, 21 Nov 2018 (approved):

	'domains' has been modified:
		Before:
			Acceptor
			Annotation
			Antigen
			Atomic composition
			Bioactivity
			Chemical descriptor
			Disease
			Donor
			Drug-like compound
			Enzyme Commission (EC) number
			Gene
			Gene Ontology (GO) enrichment
			Gene expression data
			Gene name
			Genome annotation
			Glycosylphosphatidylinositol (GPI) anchor
			Life Science
			Molecular weight
			Number of flexible bonds
			Pathway or network prediction
			Proton
			Rule of five compliance
			Sequence length
			Signal peptide
			Structure
			logP
		After:
			Acceptor
			Annotation
			Antigen
			Atomic composition
			Bioactivity
			Chemical descriptor
			DNA sequence data
			Disease
			Donor
			Drug-like compound
			Enzyme Commission (EC) number
			Gene
			Gene Ontology (GO) enrichment
			Gene expression data
			Gene name
			Genome annotation
			Glycosylphosphatidylinositol (GPI) anchor
			Life Science
			Molecular weight
			Number of flexible bonds
			Pathway or network prediction
			Proton
			Rule of five compliance
			Sequence length
			Signal peptide
			Structure
			logP
		Added:
			DNA sequence data
		Removed:

Edits to 'https://fairsharing.org/FAIRsharing.6c4fvf' by 'The FAIRsharing Team' at 18:49, 26 Sep 2016 (approved):

	'contactName' has been modified:
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			Fernn Agero
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In Collections

Chemistry

Support

General

FAQ	http://tdrtargets.org/faq
support email	info@tdrtargets.org
online documentation	http://tdrtargets.org/documentation
wikipedia	https://en.wikipedia.org/wiki/TDR_Target ...

Additional Information

Contact

Fernán Agüero ORCID

Tools

No tools defined

Access / Retrieve Data

Conditions of Use

Data Versioning

versioning of by revision control system [web application code (atomic changes)]	No link recorded
access to historical database dumps (SQL dumps) possible	No link recorded

Data Release

6-9 months

No link recorded

Data Curation

manual curation	No link recorded
submit	http://tdrtargets.org/survey

Data Access

register	http://tdrtargets.org/user/register
browse	http://tdrtargets.org/survey
search	http://tdrtargets.org/survey
file download(CSV,txt,tab-delimited)	No link recorded

Publications

Genomic-scale prioritization of drug targets: the TDR Targets database.

Agüero F., Al-Lazikani B., Aslett M., Berriman M., Buckner FS., Campbell RK., Carmona S., Carruthers IM., Chan AW., Chen F., Crowther GJ., Doyle MA., Hertz-Fowler C., Hopkins AL., McAllister G., Nwaka S., Overington JP., Pain A., Paolini GV., Pieper U., Ralph SA., Riechers A., Roos DS., Sali A., Shanmugam D., Suzuki T., Van Voorhis WC., Verlinde CL.,
Nat Rev Drug Discov 2008

View Paper (PubMed) View Publication

Identification of attractive drug targets in neglected-disease pathogens using an in silico approach.

Crowther GJ., Shanmugam D., Carmona SJ., Doyle MA., Hertz-Fowler C., Berriman M., Nwaka S., Ralph SA., Roos DS., Van Voorhis WC., Agüero F.,
PLoS Negl Trop Dis 2010

View Paper (PubMed) View Publication

TDR Targets: a chemogenomics resource for neglected diseases.

Magarinos MP,Carmona SJ,Crowther GJ,Ralph SA,Roos DS,Shanmugam D,Van Voorhis WC,Aguero F
Nucleic Acids Res 2011

View Paper (PubMed) View Publication

Related Standards

Reporting Guidelines

No guidelines defined

Terminology Artifacts

No semantic standards defined

Models and Formats

Identifier Schemas

No identifier schema standards defined

Metrics

No metrics standards defined

Related Databases

MycoBrowser leprae

Implementing Policies

This record is not implemented by any policy.

Credit

Record Maintainer

This record is maintained by fernan ORCID

Funds

Maintains

Instituto de Investigaciones Biotecnológicas, Universidad de San Martín - CONICET Lead

Undefined

University of Washington, USA (University)

Grant Number(s)

A50830| (World Health Organization, Special Programme for Research and Training in Tropical Diseases (WHO/TDR))
PICT-2010-1479 (Agencia Nacional de Promoción Científica (ANPCyT, Argentina))
PICT-Glaxo-2013-0067 (Agencia Nacional de Promoción Científica (ANPCyT, Argentina))

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