standards > reporting guideline > DOI:10.25504/FAIRsharing.89hcdg
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ready Patient Derived Xenograft Minimum Information

Abbreviation: PDX-MI


General Information
Patients-derived tumor xenograft (PDX) mouse models are an important oncology research platform to study tumor evolution, drug response and personalised medicine approaches. We identified critical attributes to accurately describe PDX production and usage and proposed the PDX-Minimum information (PDX-MI) standard, which defines the minimal information for describing the clinical attributes of a patient’s tumor, the processes of implantation and passaging of tumors in a host mouse strain, quality assurance methods, and the use PDX models in cancer research. PDX-MI standard is the result of the collaborative work from more than 50 worldwide experts over 30 worldwide institutions.



How to cite this record FAIRsharing.org: PDX-MI; Patient Derived Xenograft Minimum Information; DOI: https://doi.org/10.25504/FAIRsharing.89hcdg; Last edited: Feb. 27, 2020, 1 p.m.; Last accessed: Aug 09 2020 4:04 p.m.


This record is maintained by nathalie_conte  ORCID

Record added: Dec. 22, 2017, 2:31 p.m.
Record updated: Feb. 27, 2020, 1 p.m. by The FAIRsharing Team.

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PDX-MI: Minimal Information for Patient-Derived Tumor Xenograft Models.

Meehan TF, Conte N, Goldstein T, Inghirami G, Murakami MA, Brabetz S, Gu Z, Wiser JA, Dunn P, Begley DA, Krupke DM, Bertotti A, Bruna A, Brush MH, Byrne AT, Caldas C, Christie AL, Clark DA, Dowst H, Dry JR, Doroshow JH, Duchamp O, Evrard YA, Ferretti S, Frese KK, Goodwin NC, Greenawalt D, Haendel MA, Hermans E, Houghton PJ, Jonkers J, Kemper K, Khor TO, Lewis MT, Lloyd KCK, Mason J, Medico E, Neuhauser SB, Olson JM, Peeper DS, Rueda OM, Seong JK, Trusolino L, Vinolo E, Wechsler-Reya RJ, Weinstock DM, Welm A, Weroha SJ, Amant F, Pfister SM, Kool M, Parkinson H, Butte AJ, Bult CJ.
Cancer Research 2017

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Patients-Derived tumor Xenograft Finder
PDX Finder is an open repository for the upload and storage of clinical, genomic and functional Patient-Derived Xenograph (PDX) data which provides a comprehensive global catalogue of PDX models available for researchers across distributed repository databases. Integrated views are provided for histopathological image data, molecular classification of tumors, host mouse strain metadata, tumor genomic data and metrics on tumor response to chemotherapeutics. The data model for PDX Finder is based on the minimal information standard for PDX models developed in collaboration with a broad range of stakeholders who create and/or use PDX models in basic and pre-clinical cancer research.

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