Mechanism and Catalytic Site Atlas

Abbreviation:M-CSA

General Information

M-CSA is a database of enzyme reaction mechanisms. It provides annotation on the protein, catalytic residues, cofactors, and the reaction mechanisms of hundreds of enzymes. There are two kinds of entries in M-CSA: 'Detailed mechanism' entries are more complete and show the individual chemical steps of the mechanism as schemes with electron flow arrows; and 'Catalytic Site' entries annotate the catalytic residues necessary for the reaction, but do not show the mechanism.

This record replaces or incorporates the following deprecated resources:

Homepage https://www.ebi.ac.uk/thornton-srv/m-csa/

Countries that developed this resource Austria , Belgium , Croatia , Czech Republic , Denmark , Finland , France , Germany , Greece , Hungary , Iceland , Israel , Italy , Lithuania , Luxembourg , Malta , Montenegro , Netherlands , Norway , Portugal , Republic of Ireland , Slovakia , Spain , Sweden , Switzerland , United Kingdom

Created in 2017

Taxonomic range

All

Knowledge Domains

Subjects

How to cite this record FAIRsharing.org: M-CSA; Mechanism and Catalytic Site Atlas; DOI: https://doi.org/10.25504/FAIRsharing.BrubDI; Last edited: May 4, 2020, 11:08 a.m.; Last accessed: Sep 30 2020 9:46 p.m.

Publication for citation Mechanism and Catalytic Site Atlas (M-CSA): a database of enzyme reaction mechanisms and active sites. Ribeiro AJM,Holliday GL,Furnham N,Tyzack JD,Ferris K,Thornton JM; Nucleic Acids Res ; 2017; 10.1093/nar/gkx1012;

This record is maintained by AntonioRibeiro

Record added: April 10, 2018, 10:13 a.m.
Record updated: Feb. 26, 2020, 9:43 a.m. by AntonioRibeiro.

Show edit history

Edits to 'https://fairsharing.org/FAIRsharing.BrubDI' by 'AntonioRibeiro' at 09:43, 26 Feb 2020 (approved):

	'contact' has been modified:
		Before: Ant?nio J M Ribeiro
		After: Ant?nio Ribeiro

	'contactORCID' has been modified:
		Before: 
		After: https://orcid.org/0000-0002-2533-1231

Edits to 'https://fairsharing.org/FAIRsharing.BrubDI' by 'The FAIRsharing Team' at 13:13, 05 Feb 2020 (approved):

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			Life Science
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			Biochemistry
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			Enzymology
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			Biochemistry
			Biology
			Enzymology
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			Life Science

	'description' has been modified:
		Before: M-CSA is a database of enzyme reaction mechanisms. It provides annotation on the protein, catalytic residues, cofactors, and the reaction mechanisms of hundreds of enzymes. There are two kinds of entries in M-CSA. 'Detailed mechanism' entries are more complete and show the individual chemical steps of the mechanism as schemes with electron flow arrows. 'Catalytic Site' entries annotate the catalytic residues necessary for the reaction, but do not show the mechanism.
		After: M-CSA is a database of enzyme reaction mechanisms. It provides annotation on the protein, catalytic residues, cofactors, and the reaction mechanisms of hundreds of enzymes. There are two kinds of entries in M-CSA: 'Detailed mechanism' entries are more complete and show the individual chemical steps of the mechanism as schemes with electron flow arrows; and 'Catalytic Site' entries annotate the catalytic residues necessary for the reaction, but do not show the mechanism.

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			United Kingdom
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			Austria
			Belgium
			Croatia
			Czech Republic
			Denmark
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			Greece
			Hungary
			Iceland
			Israel
			Italy
			Lithuania
			Luxembourg
			Malta
			Montenegro
			Netherlands
			Norway
			Portugal
			Republic of Ireland
			Slovakia
			Spain
			Sweden
			Switzerland
			United Kingdom
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			Austria
			Belgium
			Croatia
			Czech Republic
			Denmark
			Finland
			France
			Germany
			Greece
			Hungary
			Iceland
			Israel
			Italy
			Lithuania
			Luxembourg
			Malta
			Montenegro
			Netherlands
			Norway
			Portugal
			Republic of Ireland
			Slovakia
			Spain
			Sweden
			Switzerland
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Edits to 'https://fairsharing.org/FAIRsharing.BrubDI' by 'The FAIRsharing Team' at 13:25, 23 Jan 2020 (approved):

	'organizations' has been modified:
		Before:
			European Molecular Biology Laboratory (EMBL), Heidelberg, Germany|http://www.embl.org|Funds
			The Wellcome Trust, UK|https://wellcome.ac.uk/|Funds
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			European Molecular Biology Laboratory (EMBL), Heidelberg, Germany|http://www.embl.org|Funds
			The Wellcome Trust, UK|https://wellcome.ac.uk/|Funds
			European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridgeshire, UK|https://www.ebi.ac.uk/|Maintains
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			European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridgeshire, UK|https://www.ebi.ac.uk/|Maintains
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Edits to 'https://fairsharing.org/FAIRsharing.BrubDI' by 'The FAIRsharing Team' at 10:34, 10 Jan 2020 (approved):

	'organizations' has been modified:
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			European Molecular Biology Laboratory (EMBL), Heidelberg, Germany|http://www.embl.org|Maintains
			European Molecular Biology Laboratory (EMBL), Heidelberg, Germany|http://www.embl.org|Funds
			The Wellcome Trust, UK|https://wellcome.ac.uk/|Funds
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			European Molecular Biology Laboratory (EMBL), Heidelberg, Germany|http://www.embl.org|Funds
			The Wellcome Trust, UK|https://wellcome.ac.uk/|Funds
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			European Molecular Biology Laboratory (EMBL), Heidelberg, Germany|http://www.embl.org|Maintains

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	'onto_domains' has been modified:
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			catalytic activity
			enzymatic reaction
			enzyme
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			Annotation
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			enzyme
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			Annotation
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			Other|https://www.ebi.ac.uk/thornton-srv/m-csa/download/|API
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			Other|https://www.ebi.ac.uk/thornton-srv/m-csa/download/|API
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Support

General

online documentation	M-CSA Documentation
online documentation	About M-CSA
online documentation	M-CSA Statistics

Additional Information

Contact

António Ribeiro ORCID

Tools

No tools defined

Access / Retrieve Data

Conditions of Use

Applies to: Data use

Creative Commons Attribution-NoDerivs 3.0 Unported (CC BY-ND 3.0)

Data Access

Browse Data	https://www.ebi.ac.uk/thornton-srv/m-csa/browse/
Search Data	https://www.ebi.ac.uk/thornton-srv/m-csa/search/
Download	https://www.ebi.ac.uk/thornton-srv/m-csa/download/

Other Web Services

API	https://www.ebi.ac.uk/thornton-srv/m-csa/download/

Publications

Mechanism and Catalytic Site Atlas (M-CSA): a database of enzyme reaction mechanisms and active sites.

Ribeiro AJM,Holliday GL,Furnham N,Tyzack JD,Ferris K,Thornton JM
Nucleic Acids Res 2017

View Paper (PubMed) View Publication

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This record is not implemented by any policy.

Credit

Record Maintainer

This record is maintained by AntonioRibeiro

Funds

The Wellcome Trust, UK (Charitable foundation)
European Molecular Biology Laboratory (EMBL), Heidelberg, Germany (Research institute)

Maintains

European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridgeshire, UK (Research institute) Lead

Mechanism and Catalytic Site Atlas

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