databases > DOI:10.25504/FAIRsharing.SFORSe

ready Sex-Associated Gene Database

Abbreviation:SAGD

General Information
Many animal species present sex differences. Sex-associated genes (SAGs), which have female-biased or male-biased expression, have major influences on the remarkable sex differences in important traits such as growth, reproduction, disease resistance and behaviors. However, the SAGs resulting in the vast majority of phenotypic sex differences are still unknown. To provide a useful resource for the functional study of SAGs, we manually curated public RNA-seq datasets with paired female and male biological replicates from the same condition and systematically re-analyzed the datasets using standardized methods. We identified 27,793 female-biased SAGs and 64,043 male-biased SAGs from 2,828 samples of 21 species, including human, chimpanzee, macaque, mouse, rat, cow, horse, chicken, zebrafish, seven fly species and five worm species. All these data were cataloged into SAGD, a user-friendly database of SAGs where users can browse SAGs by gene, species, drug, and dataset. In SAGD, the expression, annotation, targeting drugs, homologs, ontology and related RNA-seq datasets of SAGs are provided to help researchers to explore their functions and potential applications in agriculture and human health.




How to cite this record FAIRsharing.org: SAGD; Sex-Associated Gene Database; DOI: https://doi.org/10.25504/FAIRsharing.SFORSe; Last edited: Jan. 9, 2019, 3:07 p.m.; Last accessed: Sep 16 2019 1:02 p.m.

Publication for citation  SAGD: a Comprehensive Sex-Associated Gene Database from Transcriptomes Meng-Wei Shi1, Na-An Zhang1, Chuan-Ping Shi1, Chun-Jie Liu2, Zhi-Hui Luo1, Dan-Yang Wang1, An-Yuan Guo2*, Zhen-Xia Chen1*; Nucleic Acids Research ; 2018; 10.1093/nar/gky1040;


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Record added: Oct. 16, 2018, 4:27 p.m.
Record updated: Oct. 17, 2018, 12:09 p.m. by The FAIRsharing Team.

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SAGD: a Comprehensive Sex-Associated Gene Database from Transcriptomes

Meng-Wei Shi1, Na-An Zhang1, Chuan-Ping Shi1, Chun-Jie Liu2, Zhi-Hui Luo1, Dan-Yang Wang1, An-Yuan Guo2*, Zhen-Xia Chen1*
Nucleic Acids Research 2018

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  • 2016RC011 (Huazhong Agricultural University Scientific & Technological Self-innovation Foundation, China)

  • 31701259 (National Natural Science Foundation of China (NSFC), Beijing, China)

  • 31871305 (National Natural Science Foundation of China (NSFC), Beijing, China)