Sex-Associated Gene Database

Abbreviation:SAGD

General Information

Many animal species present sex differences. Sex-associated genes (SAGs), which have female-biased or male-biased expression, have major influences on the remarkable sex differences in important traits such as growth, reproduction, disease resistance and behaviors. However, the SAGs resulting in the vast majority of phenotypic sex differences are still unknown. To provide a useful resource for the functional study of SAGs, we manually curated public RNA-seq datasets with paired female and male biological replicates from the same condition and systematically re-analyzed the datasets using standardized methods. We identified 27,793 female-biased SAGs and 64,043 male-biased SAGs from 2,828 samples of 21 species, including human, chimpanzee, macaque, mouse, rat, cow, horse, chicken, zebrafish, seven fly species and five worm species. All these data were cataloged into SAGD, a user-friendly database of SAGs where users can browse SAGs by gene, species, drug, and dataset. In SAGD, the expression, annotation, targeting drugs, homologs, ontology and related RNA-seq datasets of SAGs are provided to help researchers to explore their functions and potential applications in agriculture and human health.

Homepage http://bioinfo.life.hust.edu.cn/SAGD

Countries that developed this resource China

Created in 2018

Taxonomic range

Pristionchus pacificus

Rattus norvegicus

Knowledge Domains

Subjects

How to cite this record FAIRsharing.org: SAGD; Sex-Associated Gene Database; DOI: https://doi.org/10.25504/FAIRsharing.SFORSe; Last edited: Jan. 9, 2019, 3:07 p.m.; Last accessed: Jan 19 2020 4:01 p.m.

Publication for citation SAGD: a Comprehensive Sex-Associated Gene Database from Transcriptomes Meng-Wei Shi1, Na-An Zhang1, Chuan-Ping Shi1, Chun-Jie Liu2, Zhi-Hui Luo1, Dan-Yang Wang1, An-Yuan Guo2*, Zhen-Xia Chen1*; Nucleic Acids Research ; 2018; 10.1093/nar/gky1040;

This record is maintained by zhen-xia.chen

Record added: Oct. 16, 2018, 4:27 p.m.
Record updated: Oct. 17, 2018, 12:09 p.m. by The FAIRsharing Team.

Show edit history

Edits to 'https://fairsharing.org/FAIRsharing.SFORSe' by 'The FAIRsharing Team' at 12:09, 17 Oct 2018 (approved):

	'related_databases' has been modified:
		Before:
		After:
			Expression Atlas
			Ensembl
			Gene Expression Omnibus
			Sequence Read Archive
			Ensembl Metazoa
		Added:
			Expression Atlas
			Ensembl
			Gene Expression Omnibus
			Sequence Read Archive
			Ensembl Metazoa
		Removed:

	'supportLinks' has been modified:
		Before:
		After:
			help|http://bioinfo.life.hust.edu.cn/SAGD#!/help
		Added:
			help|http://bioinfo.life.hust.edu.cn/SAGD#!/help
		Removed:

	'description' has been modified:
		Before: Many animal species present sex differences. Sex-associated genes (SAGs), which have female-biased or male-biased expression, have major influences on the remarkable sex differences in important traits such as growth, reproduction, disease resistance and behaviors. However, the SAGs resulting in the vast majority of phenotypic sex differences are still unknown. To provide a useful resource for the functional study of SAGs, we manually curated public RNA-seq datasets with paired female and male biological replicates from the same condition and systematically re-analyzed the datasets using standardized methods. We identified 27,793 female-biased SAGs and 64,043 male-biased SAGs from 2,828 samples of 21 species, including human, chimpanzee, macaque, mouse, rat, cow, horse, chicken, zebrafish, seven fly species and five worm species. All these data were cataloged into SAGD, a user-friendly database of SAGs (http://bioinfo.life.hust.edu.cn/SAGD) where users can browse SAGs by gene, species, drug, and dataset. In SAGD, the expression, annotation, targeting drugs, homologs, ontology and related RNA-seq datasets of SAGs are provided to help researchers to explore their functions and potential applications in agriculture and human health.
		After: Many animal species present sex differences. Sex-associated genes (SAGs), which have female-biased or male-biased expression, have major influences on the remarkable sex differences in important traits such as growth, reproduction, disease resistance and behaviors. However, the SAGs resulting in the vast majority of phenotypic sex differences are still unknown. To provide a useful resource for the functional study of SAGs, we manually curated public RNA-seq datasets with paired female and male biological replicates from the same condition and systematically re-analyzed the datasets using standardized methods. We identified 27,793 female-biased SAGs and 64,043 male-biased SAGs from 2,828 samples of 21 species, including human, chimpanzee, macaque, mouse, rat, cow, horse, chicken, zebrafish, seven fly species and five worm species. All these data were cataloged into SAGD, a user-friendly database of SAGs where users can browse SAGs by gene, species, drug, and dataset. In SAGD, the expression, annotation, targeting drugs, homologs, ontology and related RNA-seq datasets of SAGs are provided to help researchers to explore their functions and potential applications in agriculture and human health.

	'dataProcesses' has been modified:
		Before:
		After:
			Browse by Species
			Browse by Gene
			Browse by Drug
			Browse by Dataset
			Data Download
			Submit Data
		Added:
			Browse by Species
			Browse by Gene
			Browse by Drug
			Browse by Dataset
			Data Download
			Submit Data
		Removed:

	'domains' has been modified:
		Before:
			Animal organ development
			Differential gene expression analysis
			RNA sequencing (RNA-Seq)
		After:
			Animal Genetics
			Animal organ development
			Differential gene expression analysis
			Life Science
			RNA sequencing (RNA-Seq)
		Added:
			Animal Genetics
			Life Science
		Removed:

	'taxonomies' has been modified:
		Before:
		After:
			Bos taurus
			Caenorhabditis
			Danio rerio
			Drosophila
			Equus caballus
			Gallus gallus
			Homo sapiens
			Macaca mulatta
			Mus musculus
			Pan troglodytes
			Pristionchus pacificus
			Rattus norvegicus
		Added:
			Bos taurus
			Caenorhabditis
			Danio rerio
			Drosophila
			Equus caballus
			Gallus gallus
			Homo sapiens
			Macaca mulatta
			Mus musculus
			Pan troglodytes
			Pristionchus pacificus
			Rattus norvegicus
		Removed:

Support

General

help	SAGD Help Pages

Additional Information

Contact

Zhen-Xia Chen ORCID

Tools

No tools defined

Access / Retrieve Data

Conditions of Use

Data Curation

Submit Data

http://bioinfo.life.hust.edu.cn/SAGD#!/submission

Data Access

Browse by Species	http://bioinfo.life.hust.edu.cn/SAGD#!/browse_species
Browse by Gene	http://bioinfo.life.hust.edu.cn/#!/browse_gene
Browse by Drug	http://bioinfo.life.hust.edu.cn/SAGD#!/drug
Browse by Dataset	http://bioinfo.life.hust.edu.cn/SAGD#!/dataset
Data Download	http://bioinfo.life.hust.edu.cn/SAGD#!/download

Publications

SAGD: a Comprehensive Sex-Associated Gene Database from Transcriptomes

Meng-Wei Shi1, Na-An Zhang1, Chuan-Ping Shi1, Chun-Jie Liu2, Zhi-Hui Luo1, Dan-Yang Wang1, An-Yuan Guo2*, Zhen-Xia Chen1*
Nucleic Acids Research 2018

View Publication

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Reporting Guidelines

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This record is not implemented by any policy.

Credit

Record Maintainer

This record is maintained by zhen-xia.chen

Funds

Maintains

Huazhong Agricultural University, China (University) Lead
Huazhong University of Science and Technology, China (University)

Grant Number(s)

2016RC011 (Huazhong Agricultural University Scientific & Technological Self-innovation Foundation, China)
31701259 (National Natural Science Foundation of China (NSFC), Beijing, China)
31871305 (National Natural Science Foundation of China (NSFC), Beijing, China)

Sex-Associated Gene Database

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