IntAct molecular interaction database

Abbreviation:IntAct

Recommended

General Information

IntAct provides a freely available, open source database system and analysis tools for protein interaction data. All interactions are derived from literature curation or direct user submissions and are freely available.

Homepage http://www.ebi.ac.uk/intact

Countries that developed this resource Austria , Belgium , Croatia , Czech Republic , Denmark , Finland , France , Germany , Greece , Hungary , Iceland , Israel , Italy , Lithuania , Luxembourg , Malta , Montenegro , Netherlands , Norway , Portugal , Republic of Ireland , Slovakia , Spain , Sweden , Switzerland , United Kingdom

Created in 2003

Taxonomic range

All

Knowledge Domains

Subjects

User-defined Tags

COVID-19

In the following recommendations:

How to cite this record FAIRsharing.org: IntAct; IntAct molecular interaction database; DOI: https://doi.org/10.25504/FAIRsharing.d05nwx; Last edited: April 8, 2020, 5:13 p.m.; Last accessed: Oct 20 2020 8:59 p.m.

Publication for citation The MIntAct project--IntAct as a common curation platform for 11 molecular interaction databases. Orchard S,Ammari M,Aranda B,Breuza L,Briganti L,Broackes-Carter F,Campbell NH,Chavali G,Chen C,del-Toro N,Duesbury M,Dumousseau M,Galeota E,Hinz U,Iannuccelli M,Jagannathan S,Jimenez R,Khadake J,Lagreid A,Licata L,Lovering RC,Meldal B,Melidoni AN,Milagros M,Peluso D,Perfetto L,Porras P,Raghunath A,Ricard-Blum S,Roechert B,Stutz A,Tognolli M,van Roey K,Cesareni G,Hermjakob H; Nucleic Acids Res ; 2013; 10.1093/nar/gkt1115;

This record is maintained by orchard

Record updated: April 8, 2020, 4:54 p.m. by The FAIRsharing Team.

Show edit history

Edits to 'https://fairsharing.org/FAIRsharing.d05nwx' by 'The FAIRsharing Team' at 16:54, 08 Apr 2020 (approved):

	'user_defined_tags' has been modified:
		Before:
		After:
			COVID-19
		Added:
			COVID-19
		Removed:

Edits to 'https://fairsharing.org/FAIRsharing.d05nwx' by 'The FAIRsharing Team' at 11:24, 11 Feb 2020 (approved):

	'supportLinks' has been modified:
		Before:
			FAQ|http://www.ebi.ac.uk/intact/pages/faq/faq.xhtml
			TeSS training|https://tess.elixir-europe.org/materials/intact-molecular-interactions-at-embl-ebi
			TeSS training|https://tess.elixir-europe.org/materials/intact-quick-tour
			TeSS training|https://tess.elixir-europe.org/materials/intact-the-molecular-interactions-database-at-embl-ebi-webinar
			contact form|http://www.ebi.ac.uk/support/index.php?query=intact&conversationContext=1
			twitter|@intact_project
		After:
			FAQ|http://www.ebi.ac.uk/intact/pages/faq/faq.xhtml
			TeSS training|https://tess.elixir-europe.org/materials/intact-molecular-interactions-at-embl-ebi
			TeSS training|https://tess.elixir-europe.org/materials/intact-quick-tour
			TeSS training|https://tess.elixir-europe.org/materials/intact-the-molecular-interactions-database-at-embl-ebi-webinar
			contact form|http://www.ebi.ac.uk/support/index.php?query=intact
			online documentation|https://www.ebi.ac.uk/intact/resources/datasets
			training|https://www.ebi.ac.uk/intact/resources/training
			twitter|@intact_project
		Added:
			contact form|http://www.ebi.ac.uk/support/index.php?query=intact
			online documentation|https://www.ebi.ac.uk/intact/resources/datasets
			training|https://www.ebi.ac.uk/intact/resources/training
		Removed:
			contact form|http://www.ebi.ac.uk/support/index.php?query=intact&conversationContext=1

	'countries' has been modified:
		Before:
			European Union
		After:
			Austria
			Belgium
			Croatia
			Czech Republic
			Denmark
			Finland
			France
			Germany
			Greece
			Hungary
			Iceland
			Israel
			Italy
			Lithuania
			Luxembourg
			Malta
			Montenegro
			Netherlands
			Norway
			Portugal
			Republic of Ireland
			Slovakia
			Spain
			Sweden
			Switzerland
			United Kingdom
		Added:
			Austria
			Belgium
			Croatia
			Czech Republic
			Denmark
			Finland
			France
			Germany
			Greece
			Hungary
			Iceland
			Israel
			Italy
			Lithuania
			Luxembourg
			Malta
			Montenegro
			Netherlands
			Norway
			Portugal
			Republic of Ireland
			Slovakia
			Spain
			Sweden
			Switzerland
			United Kingdom
		Removed:
			European Union

	'licences' has been modified:
		Before:
			EBI Terms of Use|http://www.ebi.ac.uk/about/terms-of-use|Data
		After:
			EBI Terms of Use|http://www.ebi.ac.uk/about/terms-of-use|Data
			Creative Commons Attribution 4.0 International (CC BY 4.0)|https://creativecommons.org/licenses/by/4.0/|Data
		Added:
			Creative Commons Attribution 4.0 International (CC BY 4.0)|https://creativecommons.org/licenses/by/4.0/|Data
		Removed:

	'onto_disciplines' has been modified:
		Before:
			Life Science
			Ontology and Terminology
		After:
			Biology
		Added:
			Biology
		Removed:
			Life Science
			Ontology and Terminology

	'dataProcesses' has been modified:
		Before:
			Download
			Search
			Manual curation
			Monthly release
			Browse
			Versioning by date
			Access to historical files available
			web interface representation of PSI-MI XML 2.5
			web service (PSICQUIC)
			RDF export
		After:
			Download
			Search
			Manual curation
			Browse
			Submit
			RDF export
		Added:
			Submit
		Removed:
			Monthly release
			Versioning by date
			Access to historical files available
			web interface representation of PSI-MI XML 2.5
			web service (PSICQUIC)

	'publications' has been modified:
		Before:
			The IntAct molecular interaction database in 2010.|Aranda B., Achuthan P., Alam-Faruque Y., Armean I., Bridge A., Derow C., Feuermann M., Ghanbarian AT., Kerrien S., Khadake J., Kerssemakers J., Leroy C., Menden M., Michaut M., Montecchi-Palazzi L., Neuhauser SN., Orchard S., Perreau V., Roechert B., van Eijk K., Hermjakob H., |Nucleic Acids Res.|2010
			Broadening the horizon--level 2.5 of the HUPO-PSI format for molecular interactions.|Kerrien S., Orchard S., Montecchi-Palazzi L., Aranda B., Quinn AF., Vinod N., Bader GD., Xenarios I., Wojcik J., Sherman D., Tyers M., Salama JJ., Moore S., Ceol A., Chatr-Aryamontri A., Oesterheld M., Stmpflen V., Salwinski L., Nerothin J., Cerami E., Cusick ME., Vidal M., Gilson M., Armstrong J., Woollard P., Hogue C., Eisenberg D., Cesareni G., Apweiler R., Hermjakob H., |BMC Biol.|2007
			PSICQUIC and PSISCORE: accessing and scoring molecular interactions.|Aranda B., Blankenburg H., Kerrien S., Brinkman FS., Ceol A., Chautard E., Dana JM., De Las Rivas J., Dumousseau M., Galeota E., Gaulton A., Goll J., Hancock RE., Isserlin R., Jimenez RC., Kerssemakers J., Khadake J., Lynn DJ., Michaut M., O'Kelly G., Ono K., Orchard S., Prieto C., Razick S., Rigina O., Salwinski L., Simonovic M., Velankar S., Winter A., Wu G., Bader GD., Cesareni G., Donaldson IM., Eisenberg D., Kleywegt GJ., Overington J., Ricard-Blum S., Tyers M., Albrecht M., Hermjakob H., |Nat. Methods|2011
			IntAct: an open source molecular interaction database.|Hermjakob H., Montecchi-Palazzi L., Lewington C., Mudali S., Kerrien S., Orchard S., Vingron M., Roechert B., Roepstorff P., Valencia A., Margalit H., Armstrong J., Bairoch A., Cesareni G., Sherman D., Apweiler R., |Nucleic Acids Res.|2004
		After:
			The IntAct molecular interaction database in 2010.|Aranda B., Achuthan P., Alam-Faruque Y., Armean I., Bridge A., Derow C., Feuermann M., Ghanbarian AT., Kerrien S., Khadake J., Kerssemakers J., Leroy C., Menden M., Michaut M., Montecchi-Palazzi L., Neuhauser SN., Orchard S., Perreau V., Roechert B., van Eijk K., Hermjakob H., |Nucleic Acids Res.|2010
			Broadening the horizon--level 2.5 of the HUPO-PSI format for molecular interactions.|Kerrien S., Orchard S., Montecchi-Palazzi L., Aranda B., Quinn AF., Vinod N., Bader GD., Xenarios I., Wojcik J., Sherman D., Tyers M., Salama JJ., Moore S., Ceol A., Chatr-Aryamontri A., Oesterheld M., Stmpflen V., Salwinski L., Nerothin J., Cerami E., Cusick ME., Vidal M., Gilson M., Armstrong J., Woollard P., Hogue C., Eisenberg D., Cesareni G., Apweiler R., Hermjakob H., |BMC Biol.|2007
			PSICQUIC and PSISCORE: accessing and scoring molecular interactions.|Aranda B., Blankenburg H., Kerrien S., Brinkman FS., Ceol A., Chautard E., Dana JM., De Las Rivas J., Dumousseau M., Galeota E., Gaulton A., Goll J., Hancock RE., Isserlin R., Jimenez RC., Kerssemakers J., Khadake J., Lynn DJ., Michaut M., O'Kelly G., Ono K., Orchard S., Prieto C., Razick S., Rigina O., Salwinski L., Simonovic M., Velankar S., Winter A., Wu G., Bader GD., Cesareni G., Donaldson IM., Eisenberg D., Kleywegt GJ., Overington J., Ricard-Blum S., Tyers M., Albrecht M., Hermjakob H., |Nat. Methods|2011
			IntAct: an open source molecular interaction database.|Hermjakob H., Montecchi-Palazzi L., Lewington C., Mudali S., Kerrien S., Orchard S., Vingron M., Roechert B., Roepstorff P., Valencia A., Margalit H., Armstrong J., Bairoch A., Cesareni G., Sherman D., Apweiler R., |Nucleic Acids Res.|2004
			The MIntAct project--IntAct as a common curation platform for 11 molecular interaction databases.|Orchard S,Ammari M,Aranda B,Breuza L,Briganti L,Broackes-Carter F,Campbell NH,Chavali G,Chen C,del-Toro N,Duesbury M,Dumousseau M,Galeota E,Hinz U,Iannuccelli M,Jagannathan S,Jimenez R,Khadake J,Lagreid A,Licata L,Lovering RC,Meldal B,Melidoni AN,Milagros M,Peluso D,Perfetto L,Porras P,Raghunath A,Ricard-Blum S,Roechert B,Stutz A,Tognolli M,van Roey K,Cesareni G,Hermjakob H|Nucleic Acids Res|2013
		Added:
			The MIntAct project--IntAct as a common curation platform for 11 molecular interaction databases.|Orchard S,Ammari M,Aranda B,Breuza L,Briganti L,Broackes-Carter F,Campbell NH,Chavali G,Chen C,del-Toro N,Duesbury M,Dumousseau M,Galeota E,Hinz U,Iannuccelli M,Jagannathan S,Jimenez R,Khadake J,Lagreid A,Licata L,Lovering RC,Meldal B,Melidoni AN,Milagros M,Peluso D,Perfetto L,Porras P,Raghunath A,Ricard-Blum S,Roechert B,Stutz A,Tognolli M,van Roey K,Cesareni G,Hermjakob H|Nucleic Acids Res|2013
		Removed:

	'tools' has been modified:
		Before:
			Cytoscape||http://wiki.cytoscape.org/Cytoscape_User_Manual/ImportingNetworksFromWebServices
		After:
			Cytoscape||http://wiki.cytoscape.org/Cytoscape_User_Manual/ImportingNetworksFromWebServices
			PSI-MI Semantic Validator||http://www.ebi.ac.uk/intact/validator
		Added:
			PSI-MI Semantic Validator||http://www.ebi.ac.uk/intact/validator
		Removed:

Edits to 'https://fairsharing.org/FAIRsharing.d05nwx' by 'The FAIRsharing Team' at 12:17, 09 Jan 2019 (approved):

	'organizations' has been modified:
		Before:
			National Center for Research Resources, National Institutes of Health, Bethesda, MD, USA|http://www.nih.gov/about/almanac/organization/NCRR.htm|Funds
			Swiss Institute of Bioinformatics (SIB), Switzerland|https://www.sib.swiss|Maintains
			National Institute of General Medical Sciences (NIGMS), Bethesda, MD, USA|http://www.nigms.nih.gov|Funds
		After:
			National Center for Research Resources, National Institutes of Health, Bethesda, MD, USA|http://www.nih.gov/about/almanac/organization/NCRR.htm|Funds
			National Institute of General Medical Sciences (NIGMS), Bethesda, MD, USA|http://www.nigms.nih.gov|Funds
			Swiss Institute of Bioinformatics (SIB), Switzerland|https://www.sib.swiss|Maintains
			European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridgeshire, UK|https://www.ebi.ac.uk/|Maintains
			Biotechnology and Biological Sciences Research Council (BBSRC), UK|https://bbsrc.ukri.org|Funds
		Added:
			European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridgeshire, UK|https://www.ebi.ac.uk/|Maintains
			Biotechnology and Biological Sciences Research Council (BBSRC), UK|https://bbsrc.ukri.org|Funds
		Removed:

	'grants' has been modified:
		Before:
		After:
			BBSRC MIDAS grant (BB/L024179/1)
		Added:
			BBSRC MIDAS grant (BB/L024179/1)
		Removed:

Edits to 'https://fairsharing.org/FAIRsharing.d05nwx' by 'The FAIRsharing Team' at 14:21, 12 Jan 2018 (approved):

	'domains' has been modified:
		Before:
			Binding||http://purl.obolibrary.org/obo/GO_0005488
			Citation||http://edamontology.org/data_0970
			Experiment metadata||http://edamontology.org/data_2531
			Free text||http://edamontology.org/data_3671
			Gene Ontology (GO) enrichment|None|http://edamontology.org/data_3754
			Gene name||http://edamontology.org/data_2299
			Life Science|domain|http://www.fairsharing.org/ontology/SRAO_0000069
			Molecular interaction|process|http://purl.obolibrary.org/obo/MI_0000
			Molecular interactions|pathways and networks||http://edamontology.org/topic_0602
			Ontology and terminology||http://edamontology.org/topic_0089
			Protein|None|http://purl.obolibrary.org/obo/PR_000000001
			Protein domain||http://edamontology.org/data_1468
			Protein interactions||http://edamontology.org/topic_0128
		After:
			Binding||http://purl.obolibrary.org/obo/GO_0005488
			Citation||http://edamontology.org/data_0970
			Experiment metadata||http://edamontology.org/data_2531
			Free text||http://edamontology.org/data_3671
			Gene Ontology (GO) enrichment|None|http://edamontology.org/data_3754
			Gene name||http://edamontology.org/data_2299
			Life Science|domain|http://www.fairsharing.org/ontology/SRAO_0000069
			Molecular interaction|process|http://purl.obolibrary.org/obo/MI_0000
			Ontology and terminology||http://edamontology.org/topic_0089
			Protein|None|http://purl.obolibrary.org/obo/PR_000000001
			Protein domain||http://edamontology.org/data_1468
			Protein interactions||http://edamontology.org/topic_0128
		Added:
		Removed:
			Molecular interactions|pathways and networks||http://edamontology.org/topic_0602

In Collections

Data Citation Implementation

International Molecular Exchange Consortium (IMEx)

EOSC-Life

ELIXIR Core Data Resources and Deposition Databases

COVID-19 Resources

RDA Covid-19 WG Resources

Support

General

FAQ	http://www.ebi.ac.uk/intact/pages/faq/fa ...
contact form	IntAct Contact Form
online documentation	Dataset Information
training	Training
twitter	@intact_project

Additional Information

Contact

Sandra Orchard ORCID

TeSS training resources

Intact molecular interactions at embl ebi

Intact quick tour

Intact the molecular interactions database at embl ebi webinar

Tools

Cytoscape	http://wiki.cytoscape.org/Cytoscape_User_Manual/ImportingNetworksFromW ...
PSI-MI Semantic Validator	http://www.ebi.ac.uk/intact/validator

Access / Retrieve Data

Conditions of Use

Applies to: Data use

Data Curation

Manual curation	https://www.ebi.ac.uk/intact/resources/curation_manual
Submit	https://www.ebi.ac.uk/intact/submission

Data Access

Download	https://www.ebi.ac.uk/intact/downloads
Search	https://www.ebi.ac.uk/intact/search
Browse	http://www.ebi.ac.uk/ontology-lookup/?termId=MI:0469
RDF export	No link recorded

REST Web Services

RESTful services

http://www.ebi.ac.uk/Tools/webservices/psicquic/intact/webservices

SOAP Web Services

SOAP services

http://www.ebi.ac.uk/Tools/webservices/psicquic/intact/webservices

Publications

The IntAct molecular interaction database in 2010.

Aranda B., Achuthan P., Alam-Faruque Y., Armean I., Bridge A., Derow C., Feuermann M., Ghanbarian AT., Kerrien S., Khadake J., Kerssemakers J., Leroy C., Menden M., Michaut M., Montecchi-Palazzi L., Neuhauser SN., Orchard S., Perreau V., Roechert B., van Eijk K., Hermjakob H.,
Nucleic Acids Res. 2010