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Database of fuzzy protein complexes
FuzDB compiles experimentally observed fuzzy protein complexes, where intrinsic disorder (ID) is maintained upon interacting with a partner (protein, nucleic acid or small molecule) and directly impacts biological function. Entries in the database have both (i) structural evidence demonstrating the structural multiplicity or dynamic disorder of the ID region(s) in the partner bound form of the protein and (ii) in vitro or in vivo biological evidence that indicates the significance of the fuzzy region(s) in the formation, function or regulation of the assembly. Unlike the other intrinsically disordered or unfolded protein databases, FuzDB focuses on ID regions within a biological context, including higher-order assemblies and presents a detailed analysis of the structural and functional data.
How to cite this record
FAIRsharing.org: FuzDB; Database of fuzzy protein complexes; DOI: https://doi.org/10.25504/FAIRsharing.d3bm3v;
Last edited: Jan. 8, 2019, 1:25 p.m.; Last accessed: Aug 06 2020 1:52 p.m.
Record added: Oct. 17, 2017, 2:39 p.m.
Jan. 8, 2019, 1:25 p.m. by The FAIRsharing Team.
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FuzDB: database of fuzzy complexes, a tool to develop stochastic structure-function relationships for protein complexes and higher-order assemblies.
Miskei M,Antal C,Fuxreiter M
View Paper (PubMed)
Nucleic Acids Res 2016
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(Momentum Program of the Hungarian Academy of Sciences, Hungary)
(Hungarian Scientific Research Fund, Hungary)