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Information system for G protein-coupled receptors

Abbreviation:GPCRdb

General Information

The GPCRDB is a molecular-class information system that collects, combines, validates and stores large amounts of heterogenous data on G protein-coupled receptors (GPCRs). The GPCRDB contains data on sequences, ligand binding constants and mutations. In addition, many different types of computationally derived data are stored such as multiple sequence alignments and homology models.

Homepage http://gpcrdb.org/

Countries that developed this resource Denmark , Netherlands

Created in 1997

Taxonomic range

All

Knowledge Domains

Subjects

How to cite this record FAIRsharing.org: GPCRdb; Information system for G protein-coupled receptors; DOI: https://doi.org/10.25504/FAIRsharing.e4n3an; Last edited: April 26, 2021, 9:26 a.m.; Last accessed: Oct 20 2021 1:54 a.m.

Publication for citation GPCRdb in 2021: integrating GPCR sequence, structure and function. Kooistra AJ,Mordalski S,Pandy-Szekeres G,Esguerra M,Mamyrbekov A,Munk C,Keseru GM,Gloriam DE; Nucleic Acids Res ; 2020; 10.1093/nar/gkaa1080;

This record is maintained by AJK_dev ORCID

Record updated: April 20, 2021, 4:56 p.m. by The FAIRsharing Team.

Show edit history

Edits to 'https://fairsharing.org/FAIRsharing.e4n3an' by 'The FAIRsharing Team' at 16:56, 20 Apr 2021 (approved):

	'shortname' has been modified:
		Before: GPCRDB
		After: GPCRdb

	'name' has been modified:
		Before: Information system for G protein-coupled receptors (GPCRs)
		After: Information system for G protein-coupled receptors

Edits to 'https://fairsharing.org/FAIRsharing.e4n3an' by 'AJK_dev' at 15:37, 20 Apr 2021 (approved):

	'licences' has been modified:
		Before:
		After:
			Apache License 2.0|http://www.apache.org/licenses/LICENSE-2.0|Software
		Added:
			Apache License 2.0|http://www.apache.org/licenses/LICENSE-2.0|Software
		Removed:

	'publications' has been modified:
		Before:
			GPCRDB: information system for G protein-coupled receptors.|Vroling B., Sanders M., Baakman C., Borrmann A., Verhoeven S., Klomp J., Oliveira L., de Vlieg J., Vriend G., |Nucleic Acids Res.|2011
			GPCRDB: an information system for G protein-coupled receptors.|Horn F,Weare J,Beukers MW,Horsch S,Bairoch A,Chen W,Edvardsen O,Campagne F,Vriend G|Nucleic Acids Res|1998
			GPCRDB information system for G protein-coupled receptors.|Horn F,Bettler E,Oliveira L,Campagne F,Cohen FE,Vriend G|Nucleic Acids Res|2003
			GPCRDB: an information system for G protein-coupled receptors.|Isberg V,Vroling B,van der Kant R,Li K,Vriend G,Gloriam D|Nucleic Acids Res|2013
			GPCRdb: an information system for G protein-coupled receptors.|Isberg V,Mordalski S,Munk C,Rataj K,Harpsoe K,Hauser AS,Vroling B,Bojarski AJ,Vriend G,Gloriam DE|Nucleic Acids Res|2015
			GPCRdb: the G protein-coupled receptor database - an introduction.|Munk C,Isberg V,Mordalski S,Harpsoe K,Rataj K,Hauser AS,Kolb P,Bojarski AJ,Vriend G,Gloriam DE|Br J Pharmacol|2016
			GPCRdb in 2018: adding GPCR structure models and ligands.|Pandy-Szekeres G,Munk C,Tsonkov TM,Mordalski S,Harpsoe K,Hauser AS,Bojarski AJ,Gloriam DE|Nucleic Acids Res|2017
		After:
			GPCRDB: information system for G protein-coupled receptors.|Vroling B., Sanders M., Baakman C., Borrmann A., Verhoeven S., Klomp J., Oliveira L., de Vlieg J., Vriend G., |Nucleic Acids Res.|2011
			GPCRDB: an information system for G protein-coupled receptors.|Horn F,Weare J,Beukers MW,Horsch S,Bairoch A,Chen W,Edvardsen O,Campagne F,Vriend G|Nucleic Acids Res|1998
			GPCRDB information system for G protein-coupled receptors.|Horn F,Bettler E,Oliveira L,Campagne F,Cohen FE,Vriend G|Nucleic Acids Res|2003
			GPCRDB: an information system for G protein-coupled receptors.|Isberg V,Vroling B,van der Kant R,Li K,Vriend G,Gloriam D|Nucleic Acids Res|2013
			GPCRdb: an information system for G protein-coupled receptors.|Isberg V,Mordalski S,Munk C,Rataj K,Harpsoe K,Hauser AS,Vroling B,Bojarski AJ,Vriend G,Gloriam DE|Nucleic Acids Res|2015
			GPCRdb: the G protein-coupled receptor database - an introduction.|Munk C,Isberg V,Mordalski S,Harpsoe K,Rataj K,Hauser AS,Kolb P,Bojarski AJ,Vriend G,Gloriam DE|Br J Pharmacol|2016
			GPCRdb in 2018: adding GPCR structure models and ligands.|Pandy-Szekeres G,Munk C,Tsonkov TM,Mordalski S,Harpsoe K,Hauser AS,Bojarski AJ,Gloriam DE|Nucleic Acids Res|2017
			GPCRdb in 2021: integrating GPCR sequence, structure and function.|Kooistra AJ,Mordalski S,Pandy-Szekeres G,Esguerra M,Mamyrbekov A,Munk C,Keseru GM,Gloriam DE|Nucleic Acids Res|2020
		Added:
			GPCRdb in 2021: integrating GPCR sequence, structure and function.|Kooistra AJ,Mordalski S,Pandy-Szekeres G,Esguerra M,Mamyrbekov A,Munk C,Keseru GM,Gloriam DE|Nucleic Acids Res|2020
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	'dataProcesses' has been modified:
		Before:
			search, data access, http://gpcrdb.org/protein/
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			search, data access, http://gpcrdb.org/protein/
			Repository for GPCRdb data, data release, https://github.com/protwis/gpcrdb_data/
			Source code for GPCRdb platform, data release, https://github.com/protwis/protwis/
		Added:
			Repository for GPCRdb data, data release, https://github.com/protwis/gpcrdb_data/
			Source code for GPCRdb platform, data release, https://github.com/protwis/protwis/
		Removed:

Edits to 'https://fairsharing.org/FAIRsharing.e4n3an' by 'The FAIRsharing Team' at 14:30, 20 Apr 2021 (approved):

	'licences' has been modified:
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			Publicly available data||Data
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			Publicly available data||Data

Edits to 'https://fairsharing.org/FAIRsharing.e4n3an' by 'AJK_dev' at 16:44, 15 Apr 2020 (approved):

	'standardsImplemented' has been modified:
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			FASTA Sequence Format
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			FASTA Sequence Format
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	'related_databases' has been modified:
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			NucleaRDB
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			ChEMBL
			NucleaRDB
			DrugBank
			RCSB Protein Data Bank
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			ChEMBL
			DrugBank
			RCSB Protein Data Bank
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Edits to 'https://fairsharing.org/FAIRsharing.e4n3an' by 'AJK_dev' at 16:41, 15 Apr 2020 (approved):

	'organizations' has been modified:
		Before:
			Carlsberg Foundation, Copenhagen, Denmark|http://www.carlsberggroup.com/Company/Foundations/CARLSBERGFOUNDATION/Pages/Default.aspx|Funds
			Centre for Molecular and Biomolecular Informatics (CMBI), Nijmegen, Netherland|http://www2.cmbi.ru.nl/|Maintains
			Danish Council for Independent Research, Denmark|http://ufm.dk/en/research-and-innovation/councils-and-commissions/the-danish-council-for-independent-research|Funds
			Life sciences, genomics and biotechnology for health, European Commission (EC) FP6|https://ec.europa.eu/research/fp6/index_en.cfm?p=1|Funds
			Lundbeck Foundation, Copenhagen, Denmark|https://www.lundbeckfonden.com/en/|Funds
			NewProt project, European Union|http://europa.eu/european-union/about-eu/funding-grants_en|Funds
			Polish National Science Centre, Poland|https://www.ncn.gov.pl/?language=en|Funds
			European Union (EU)|http://europa.eu/index_en.htm|Funds
			The European Research Council (ERC)|https://erc.europa.eu/|Funds
		After:
			Carlsberg Foundation, Copenhagen, Denmark|http://www.carlsberggroup.com/Company/Foundations/CARLSBERGFOUNDATION/Pages/Default.aspx|Funds
			Danish Council for Independent Research, Denmark|http://ufm.dk/en/research-and-innovation/councils-and-commissions/the-danish-council-for-independent-research|Funds
			Life sciences, genomics and biotechnology for health, European Commission (EC) FP6|https://ec.europa.eu/research/fp6/index_en.cfm?p=1|Funds
			Lundbeck Foundation, Copenhagen, Denmark|https://www.lundbeckfonden.com/en/|Funds
			NewProt project, European Union|http://europa.eu/european-union/about-eu/funding-grants_en|Funds
			Polish National Science Centre, Poland|https://www.ncn.gov.pl/?language=en|Funds
			European Union (EU)|http://europa.eu/index_en.htm|Funds
			The European Research Council (ERC)|https://erc.europa.eu/|Funds
			Centre for Molecular and Biomolecular Informatics (CMBI), Nijmegen, Netherland|http://www2.cmbi.ru.nl/|Maintains
			Department of Drug Design and Pharmacology, University of Copenhagen|http://drug.ku.dk/|Maintains
		Added:
			Department of Drug Design and Pharmacology, University of Copenhagen|http://drug.ku.dk/|Maintains
		Removed:

	'supportLinks' has been modified:
		Before:
			email|gpcrdb@cmbi.ru.nl
			help|http://docs.gpcrdb.org/index.html#tutorial
		After:
			email|info@gpcrdb.org
			online documentation|http://docs.gpcrdb.org/index.html
			training|https://www.youtube.com/channel/UCy_OEfBkOdshK9Tsl08nvAw
		Added:
			email|info@gpcrdb.org
			online documentation|http://docs.gpcrdb.org/index.html
			training|https://www.youtube.com/channel/UCy_OEfBkOdshK9Tsl08nvAw
		Removed:
			email|gpcrdb@cmbi.ru.nl
			help|http://docs.gpcrdb.org/index.html#tutorial

	'countries' has been modified:
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			Netherlands
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			Denmark
			Netherlands
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			Denmark
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	'onto_domains' has been modified:
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			Sequence alignment
			homologous
			orthologous
			protein
			small molecule
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			Protein structure
			SNP
			Sequence alignment
			Structure-based sequence alignment
			bioactivity assay
			drug
			homologous
			mutation
			orthologous
			protein
			small molecule
		Added:
			Protein structure
			SNP
			Structure-based sequence alignment
			bioactivity assay
			drug
			mutation
		Removed:

	'publications' has been modified:
		Before:
			GPCRDB: information system for G protein-coupled receptors.|Vroling B., Sanders M., Baakman C., Borrmann A., Verhoeven S., Klomp J., Oliveira L., de Vlieg J., Vriend G., |Nucleic Acids Res.|2011
			GPCRDB: an information system for G protein-coupled receptors.|Horn F,Weare J,Beukers MW,Horsch S,Bairoch A,Chen W,Edvardsen O,Campagne F,Vriend G|Nucleic Acids Res|1998
			GPCRDB information system for G protein-coupled receptors.|Horn F,Bettler E,Oliveira L,Campagne F,Cohen FE,Vriend G|Nucleic Acids Res|2003
			GPCRDB: an information system for G protein-coupled receptors.|Isberg V,Vroling B,van der Kant R,Li K,Vriend G,Gloriam D|Nucleic Acids Res|2013
			GPCRdb: an information system for G protein-coupled receptors.|Isberg V,Mordalski S,Munk C,Rataj K,Harpsoe K,Hauser AS,Vroling B,Bojarski AJ,Vriend G,Gloriam DE|Nucleic Acids Res|2015
			GPCRdb: the G protein-coupled receptor database - an introduction.|Munk C,Isberg V,Mordalski S,Harpsoe K,Rataj K,Hauser AS,Kolb P,Bojarski AJ,Vriend G,Gloriam DE|Br J Pharmacol|2016
		After:
			GPCRDB: information system for G protein-coupled receptors.|Vroling B., Sanders M., Baakman C., Borrmann A., Verhoeven S., Klomp J., Oliveira L., de Vlieg J., Vriend G., |Nucleic Acids Res.|2011
			GPCRDB: an information system for G protein-coupled receptors.|Horn F,Weare J,Beukers MW,Horsch S,Bairoch A,Chen W,Edvardsen O,Campagne F,Vriend G|Nucleic Acids Res|1998
			GPCRDB information system for G protein-coupled receptors.|Horn F,Bettler E,Oliveira L,Campagne F,Cohen FE,Vriend G|Nucleic Acids Res|2003
			GPCRDB: an information system for G protein-coupled receptors.|Isberg V,Vroling B,van der Kant R,Li K,Vriend G,Gloriam D|Nucleic Acids Res|2013
			GPCRdb: an information system for G protein-coupled receptors.|Isberg V,Mordalski S,Munk C,Rataj K,Harpsoe K,Hauser AS,Vroling B,Bojarski AJ,Vriend G,Gloriam DE|Nucleic Acids Res|2015
			GPCRdb: the G protein-coupled receptor database - an introduction.|Munk C,Isberg V,Mordalski S,Harpsoe K,Rataj K,Hauser AS,Kolb P,Bojarski AJ,Vriend G,Gloriam DE|Br J Pharmacol|2016
			GPCRdb in 2018: adding GPCR structure models and ligands.|Pandy-Szekeres G,Munk C,Tsonkov TM,Mordalski S,Harpsoe K,Hauser AS,Bojarski AJ,Gloriam DE|Nucleic Acids Res|2017
		Added:
			GPCRdb in 2018: adding GPCR structure models and ligands.|Pandy-Szekeres G,Munk C,Tsonkov TM,Mordalski S,Harpsoe K,Hauser AS,Bojarski AJ,Gloriam DE|Nucleic Acids Res|2017
		Removed:

	'accessPoints' has been modified:
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			REST|https://gpcrdb.org/services/reference/|API reference
		Added:
			REST|https://gpcrdb.org/services/reference/|API reference
		Removed:

	'tools' has been modified:
		Before:
			blast||http://gpcrdb.org/alignment/blastsearch
		After:
			blast||http://gpcrdb.org/alignment/blastsearch
			Construct Design Tool||https://gpcrdb.org/construct/design
		Added:
			Construct Design Tool||https://gpcrdb.org/construct/design
		Removed:

Edits to 'https://fairsharing.org/FAIRsharing.e4n3an' by 'The FAIRsharing Team' at 19:28, 28 Sep 2016 (approved):

	'contactName' has been modified:
		Before:
			
		After:
			David Gloriam
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Edits to 'https://fairsharing.org/FAIRsharing.e4n3an' by 'The FAIRsharing Team' at 19:25, 28 Sep 2016 (approved):

	'homepage' has been modified:
		Before: http://www.gpcr.org/7tm/
		After: http://gpcrdb.org/ Domain list has changed:  Previous values: Protein|material|http://purl.org/obo/owl/GO#GO_0003675 Small molecule|material| New values:  Protein|material|http://purl.org/obo/owl/GO#GO_0003675 Small molecule|material| Life Science|domain| Alignment|| Homologs & orthologs|| Publication List has changed:  Previous values: GPCRDB: information system for G protein-coupled receptors. New values:  GPCRDB: information system for G protein-coupled receptors. GPCRDB: an information system for G protein-coupled receptors. GPCRDB information system for G protein-coupled receptors. GPCRDB: an information system for G protein-coupled receptors. GPCRdb: an information system for G protein-coupled receptors. GPCRdb: the G protein-coupled receptor database - an introduction. Tools have changed:  Previous values: search BLAST browse search BLAST browse New values:  blast Support links have changed:  Previous values: http://www.gpcr.org/7tm/faq New values:  http://docs.gpcrdb.org/index.html#tutorial Data processes have changed:  Previous values: Download New values:  search Organisations have changed:  Previous values: CMBI New values:  Centre for Molecular and Biomolecular Informatics (CMBI)|Netherland Grants have changed:  Previous values: New values:  PL 950224 LHSG-CT-2004-512092 R54-A5441 R77-A6854 289350 DE-ORPHAN 639125 R163-2013-16327 1331-00180 2014/12/T/NZ2/00529

In Collections

RDA Covid-19 WG Resources

Support

General

support email	General GPCRdb contact address
online documentation	GPCRdb documentation and help pages
training	GPCRdb YouTube channel with updates and ...

Additional Information

Contact

David Gloriam ORCID

Tools

blast	http://gpcrdb.org/alignment/blastsearch
Construct Design Tool	https://gpcrdb.org/construct/design

Access / Retrieve Data

Conditions of Use

Applies to: Database software

Apache License 2.0

Data Release

Repository for GPCRdb data	https://github.com/protwis/gpcrdb_data/
Source code for GPCRdb platform	https://github.com/protwis/protwis/

Data Access

http://gpcrdb.org/protein/

REST Web Services

API reference

https://gpcrdb.org/services/reference/

Publications

GPCRDB: information system for G protein-coupled receptors.

Vroling B., Sanders M., Baakman C., Borrmann A., Verhoeven S., Klomp J., Oliveira L., de Vlieg J., Vriend G.,
Nucleic Acids Res. 2011