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ready Pocket Similarity Search using Multiple-Sketches


General Information
POcket Similarity Search Using Multiple-Sketches (PoSSuM) includes all the discovered protein-small molecule binding site pairs with annotations of various types (e.g., UniProt, CATH, SCOP, SCOPe, EC number and Gene ontology). PoSSuM enables rapid exploration of similar binding sites among structures with different global folds as well as similar folds. Moreover, PoSSuM is useful for predicting the binding ligand for unbound structures.

How to cite this record PoSSuM; Pocket Similarity Search using Multiple-Sketches; DOI:; Last edited: Jan. 8, 2019, 1:15 p.m.; Last accessed: Nov 29 2021 2:46 p.m.

This record is maintained by JunichiIto

Record updated: Sept. 27, 2016, 11:28 a.m. by The FAIRsharing Team.

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PoSSuM: a database of similar protein-ligand binding and putative pockets.

Ito J., Tabei Y., Shimizu K., Tsuda K., Tomii K.,
Nucleic Acids Res. 2012

View Paper (PubMed)

PDB-scale analysis of known and putative ligand-binding sites with structural sketches.

Ito J., Tabei Y., Shimizu K., Tomii K., Tsuda K.,
Proteins 2012

View Paper (PubMed)

PoSSuM v.2.0: data update and a new function for investigating ligand analogs and target proteins of small-molecule drugs.

Ito J,Ikeda K,Yamada K,Mizuguchi K,Tomii K
Nucleic Acids Res 2014

View Paper (PubMed) View Publication

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Grant Number(s)

  • KAKENHI 23500374 (Japan Society for the Promotion of Science, Tokyo, Japan)