databases > DOI:10.25504/FAIRsharing.h3tjtr

ready Comparative Toxicogenomics Database

Abbreviation:CTD

General Information
The Comparative Toxicogenomics Database (CTD) advances understanding of the effects of environmental chemicals on human health. Biocurators manually curate chemical-gene, chemical-disease, and gene-disease relationships from the scientific literature. This core data is then internally integrated to generate inferred chemical-gene-disease networks. Additionally, the core data is integrated with external data sets (such as Gene Ontology and pathway annotations) to predict many novel associations between different data types. A unique and powerful feature of CTD is the inferred relationships generated by data integration that helps turn knowledge into discoveries by identifying novel connections between chemicals, genes, diseases, pathways, and GO annotations that might not otherwise be apparent using other biological resources.




How to cite this record FAIRsharing.org: CTD; Comparative Toxicogenomics Database; DOI: https://doi.org/10.25504/FAIRsharing.h3tjtr; Last edited: Nov. 23, 2018, 11:26 a.m.; Last accessed: Dec 16 2018 3:24 p.m.

How to cite this resource  The Comparative Toxicogenomics Database: update 2019. Davis AP,Grondin CJ,Johnson RJ,Sciaky D,McMorran R,Wiegers J,Wiegers TC,Mattingly CJ; Nucleic Acids Res ; 2018; 10.1093/nar/gky868;


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Record updated: Nov. 8, 2018, 10:42 a.m. by The FAIRsharing Team.

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Publications

MEDIC: a practical disease vocabulary used at the Comparative Toxicogenomics Database.

Davis AP., Wiegers TC., Rosenstein MC., Mattingly CJ.
Database (Oxford) 2012

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The Comparative Toxicogenomics Database: update 2013

Davis AP, Murphy CG, Johnson R, Lay JM, Lennon-Hopkins K, Saraceni-Richards C, Sciaky D, King BL, Rosenstein MC, Wiegers TC, Mattingly CJ.
Nucleic Acids Research 2013

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Targeted journal curation as a method to improve data currency at the Comparative Toxicogenomics Database

Davis AP, Johnson RJ, Lennon-Hopkins K, Sciaky D, Rosenstein MC, Wiegers TC, Mattingly CJ
Database (Oxford) 2012

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A CTD-Pfizer collaboration: manual curation of 88,000 scientific articles text mined for drug-disease and drug-phenotype interactions

Davis AP, Wiegers TC, Roberts PM, King BL, Lay JM, Lennon-Hopkins K, Sciaky D, Johnson R, Keating H, Greene N, Hernandez R, McConnell KJ, Enayetallah AE, Mattingly CJ.
Database (Oxford) 2013

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Text mining effectively scores and ranks the literature for improving chemical-gene-disease curation at the Comparative Toxicogenomics Database

Davis AP, Wiegers TC, Johnson RJ, Lay JM, Lennon-Hopkins K, Saraceni-Richards C, Sciaky D, Murphy CG, Mattingly CJ.
PLoS One 2013

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The curation paradigm and application tool used for manual curation of the scientific literature at the Comparative Toxicogenomics Database

Davis AP, Wiegers TC, Rosenstein MC, Murphy CG, Mattingly CJ.
Database (Oxford) 2011

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DiseaseComps: a metric that discovers similar diseases based upon common toxicogenomic profiles at CTD

Davis AP, Rosenstein MC, Wiegers TC, Mattingly CJ.
Bioinformation 2011

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GeneComps and ChemComps: a new CTD metric to identify genes and chemicals with shared toxicogenomic profiles

Davis AP, Murphy CG, Saraceni-Richards CA, Rosenstein MC, Wiegers TC, Hampton TH, Mattingly CJ.
Bioinformation 2009

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The Comparative Toxicogenomics Database facilitates identification and understanding of chemical-gene-disease associations: arsenic as a case study

Davis AP, Murphy CG, Rosenstein MC, Wiegers TC, Mattingly CJ
BMC Med Genomics 2008

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Chemical-Induced Phenotypes at CTD Help Inform the Predisease State and Construct Adverse Outcome Pathways.

Davis AP,Wiegers TC,Wiegers J,Johnson RJ,Sciaky D,Grondin CJ,Mattingly CJ
Toxicol Sci 2018

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Accessing an Expanded Exposure Science Module at the Comparative Toxicogenomics Database.

Grondin CJ,Davis AP,Wiegers TC,Wiegers JA,Mattingly CJ
Environ Health Perspect 2018

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The Comparative Toxicogenomics Database: update 2017.

Davis AP,Grondin CJ,Johnson RJ,Sciaky D,King BL,McMorran R,Wiegers J,Wiegers TC,Mattingly CJ
Nucleic Acids Res 2016

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Advancing Exposure Science through Chemical Data Curation and Integration in the Comparative Toxicogenomics Database.

Grondin CJ,Davis AP,Wiegers TC,King BL,Wiegers JA,Reif DM,Hoppin JA,Mattingly CJ
Environ Health Perspect 2016

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Generating Gene Ontology-Disease Inferences to Explore Mechanisms of Human Disease at the Comparative Toxicogenomics Database.

Davis AP,Wiegers TC,King BL,Wiegers J,Grondin CJ,Sciaky D,Johnson RJ,Mattingly CJ
PLoS One 2016

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The Comparative Toxicogenomics Database's 10th year anniversary: update 2015.

Davis AP,Grondin CJ,Lennon-Hopkins K,Saraceni-Richards C,Sciaky D,King BL,Wiegers TC,Mattingly CJ
Nucleic Acids Res 2014

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The Comparative Toxicogenomics Database: update 2019.

Davis AP,Grondin CJ,Johnson RJ,Sciaky D,McMorran R,Wiegers J,Wiegers TC,Mattingly CJ
Nucleic Acids Res 2018

View Paper (PubMed) View Publication

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  • This record is maintained by apdavis

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  • ES014065 (The National Institute of Environmental Health Sciences, NIH, USA)

  • ES019604 (The National Institute of Environmental Health Sciences, NIH, USA)