Minimum Information Required for a Drug Metabolism Enzymes and Transporters Experiment

Abbreviation: MIDE

General Information

Pharmacogenomics studies are expanding exponentially, both in terms of number and amount of data generated. To facilitate future research and diagnostic applications, Affymetrix has developed a microarray targeting known genetic variations in absorption, distribution, metabolism, excretion, toxicity (ADMET) genes. The array, known as Drug Metabolising Enzymes and Transporters (DMET Plus), comprises 1,936 variants across 231genes, including 5 copy number loci involved in drug metabolism and transport. Being designed to identify genetic variants in patients presenting different drug responses and risks for adverse drug reactions, DMET constitutes a valuable tool for pharmacogenomics and clinical studies. For effective DMET data interpretation, sharing, reporting and use across the scientific community, we propose the Minimum Information required for a DMET Experiment reporting (MIDE). MIDE aims to provide reporting guidelines and describe the information required for reporting to public databases. In this article we describe MIDE and discuss its broader applications to other platforms.

Homepage http://bioweb.cpgr.org.za/mide/mide.doc

Countries that developed this resource South Africa

Created in 2011

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All

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How to cite this record FAIRsharing.org: MIDE; Minimum Information Required for a Drug Metabolism Enzymes and Transporters Experiment; DOI: https://doi.org/10.25504/FAIRsharing.jbg4kp; Last edited: March 12, 2019, 5:17 p.m.; Last accessed: Sep 24 2020 3:03 a.m.

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Record added: Dec. 8, 2015, 1:49 p.m.
Record updated: March 12, 2019, 4:25 p.m. by The FAIRsharing Team.

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Edits to 'https://fairsharing.org/FAIRsharing.jbg4kp' by 'agbeltran' at 16:25, 12 Mar 2019 (approved):

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		After: http://bioweb.cpgr.org.za/mide/mide.doc

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Edits to 'https://fairsharing.org/FAIRsharing.jbg4kp' by 'The FAIRsharing Team' at 10:36, 23 Sep 2016 (approved):

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			Dr. Judit Kumuthini
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			Judit Kumuthini
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			Drug and clinical candidate annotations||
			Gene annotation relevant to drug discovery||
			Pharmacogenomics|process|
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			Drug and clinical candidate annotations||
			Gene annotation relevant to drug discovery||
			Pharmacogenomics|process|
			Biomedical Science|None|
			Standard|information content entity|
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			All|http://identifiers.org/taxonomy/1?resource=MIR:00100019
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In Collections

Minimum Information for Biological and Biomedical Investigations

Chemistry

RDA Covid-19 WG Resources

Support

General

help	http://www.ktp.cpgr.org.za
schema file	MIDE XML Schema File

Additional Information

Contact

Judit Kumuthini

Tools

No tools defined

Schemas

http://bioweb.cpgr.org.za/mide/mide.xsd

No XSD schemas defined

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Conditions of Use

Publications

Minimum information required for a DMET experiment reporting

Judit Kumuthini*, Mamana Mbiyavanga, Emile R Chimusa, Jyotishman Pathak, Panu Somervuo, Ron HN Van Schaik, Vita Dolzan, Clint Mizzi, Kusha Kalideen, Raj S Ramesar, Milan Macek, George P Patrinos, & Alessio Squassina
Pharmacogenomics 2016

View Paper (PubMed) View Publication

Related Standards

Reporting Guidelines

No guidelines defined

Terminology Artifacts

Ontology for Drug Discovery Investigations

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No syntax standards defined

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Record Maintainer

This record is maintained by bioinformatics

Funds

Human Heredity and Health in Africa (H3Africa) Initiative, National Institutes of Health, USA (Government body)
H3ABioNet (Consortium)

Maintains

Centre for Proteomic and Genomic Research (CPGR), Cape Town, South Africa (Research institute)

Grant Number(s)

NIH Common Fund Award /NHGRI Grant Number U41HG006941 through H3AbioNet project (H3ABioNet)

Minimum Information Required for a Drug Metabolism Enzymes and Transporters Experiment

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