standards > terminology artifact > DOI:10.25504/FAIRsharing.k893xa
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ready MHC Restriction Ontology

Abbreviation: MRO

General Information
MHC molecules form a highly diverse family of proteins that play a key role in cellular immune recognition. No consistent nomenclature exists across different vertebrate species. To correctly represent MHC related data in The Immune Epitope Database (IEDB), we built upon a previously established MHC ontology (MaHCO) and created MRO to represent MHC molecules as they relate to immunological experiments. MRO models MHC protein chains from 16 species, deals with different approaches used to identify MHC, such as direct sequencing verses serotyping, relates engineered MHC molecules to naturally occurring ones, connects genetic loci, alleles, protein chains and multichain proteins, and establishes evidence codes for MHC restriction.


Countries that developed this resource United States

Created in 2016

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How to cite this record MRO; MHC Restriction Ontology; DOI:; Last edited: March 3, 2020, 1:13 p.m.; Last accessed: Jan 23 2022 11:29 a.m.

Publication for citation  An ontology for major histocompatibility restriction. Vita R,Overton JA,Seymour E,Sidney J,Kaufman J,Tallmadge RL,Ellis S,Hammond J,Butcher GW,Sette A,Peters B; J Biomed Semantics ; 2016; 10.1186/s13326-016-0045-5;

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Record added: Oct. 24, 2017, 9:41 a.m.
Record updated: March 3, 2020, 1:12 p.m. by The FAIRsharing Team.

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An ontology for major histocompatibility restriction.

Vita R,Overton JA,Seymour E,Sidney J,Kaufman J,Tallmadge RL,Ellis S,Hammond J,Butcher GW,Sette A,Peters B
J Biomed Semantics 2016

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Related Databases (3)
IPD-MHC - Major Histocompatibility Complex Database
The IPD-MHC Database provides a centralised repository for sequences of the Major Histocompatibility Complex (MHC) from a number of different species. Through a number of international collaborations IPD is able to provide the MHC sequences of different species. The sequences provided by each group are curated by experts in the field and then submitted to the central database.

ImMunoGeneTics Information System
IMGT is a high-quality integrated knowledge resource specialized in the immunoglobulins (IG) or antibodies, T cell receptors (TR), major histocompatibility complex (MHC) of human and other vertebrate species, and in the immunoglobulin superfamily (IgSF), major histocompatibility complex superfamily (MhcSF) and related proteins of the immune system (RPI) of vertebrates and invertebrates.

Immune Epitope Database
The IEDB provides the scientific community with a central repository of freely accessible epitope data and epitope prediction and analysis resources. The IEDB is a publicly accessible, comprehensive immune epitope database containing peptidic linear and conformational epitopes and non peptidic epitopes such as lipids, metals, drugs, carbohydrates, etc, with published or submitted antibody, T cell, MHC binding or MHC ligand elution experimental assays. Epitope data related to infectious diseases, allergy, autoimmunity and transplant tested in humans, non human primates, and any other species can be found in the IEDB.

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  • This record is maintained by rvita