databases > DOI:10.25504/FAIRsharing.mihb12

ready Kinase-Ligand Interaction Fingerprints and Structures database

Abbreviation:KLIFS

General Information
Kinase-Ligand Interaction Fingerprints and Structures database (KLIFS) is a database that revolves around the protein structure of catalytic kinase domains and the way kinase inhibitors can interact with them. Based on the underlying systematic and consistent protocol all (currently human and mouse) kinase structures and the binding mode of kinase ligands can be directly compared to each other. Moreover, because of the classification of an all-encompassing binding site of 85 residues it is possible to compare the interaction patterns of kinase-inhibitors to each other to, for example, identify crucial interactions determining kinase-inhibitor selectivity.

Homepage https://klifs.vu-compmedchem.nl

Countries that developed this resource Netherlands

Created in 2013





How to cite this record FAIRsharing.org: KLIFS; Kinase-Ligand Interaction Fingerprints and Structures database; DOI: https://doi.org/10.25504/FAIRsharing.mihb12; Last edited: May 4, 2020, 11:08 a.m.; Last accessed: Sep 30 2020 10:10 p.m.

Publication for citation  KLIFS: a structural kinase-ligand interaction database. Kooistra AJ,Kanev GK,van Linden OP,Leurs R,de Esch IJ,de Graaf C; Nucleic Acids Res ; 2015; 10.1093/nar/gkv1082;


This record is maintained by AJK_dev  ORCID

Record added: April 14, 2020, 4:52 p.m.
Record updated: April 20, 2020, 9:48 a.m. by The FAIRsharing Team.

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training Tutorial

Tools
KLIFS nodes for KNIME https://www.knime.com/3d-e-chem-nodes-for-knime 1.4.2

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Conditions of Use


Data Access

Browse https://klifs.vu-compmedchem.nl/result.php?flag_browse=TRUE
Search https://klifs.vu-compmedchem.nl/search.php

REST Web Services

OpenAPI description http://klifs.vu-compmedchem.nl/swagger/


Publications

KLIFS: a structural kinase-ligand interaction database.

Kooistra AJ,Kanev GK,van Linden OP,Leurs R,de Esch IJ,de Graaf C
Nucleic Acids Res 2015

View Paper (PubMed) View Publication

KLIFS: a knowledge-based structural database to navigate kinase-ligand interaction space.

van Linden OP,Kooistra AJ,Leurs R,de Esch IJ,de Graaf C
J Med Chem 2013

View Paper (PubMed) View Publication

The Landscape of Atypical and Eukaryotic Protein Kinases.

Kanev GK,de Graaf C,de Esch IJP,Leurs R,Wurdinger T,Westerman BA,Kooistra AJ
Trends Pharmacol Sci 2019

View Paper (PubMed) View Publication

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