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ready Deciphering the Mechanisms of Developmental Disorders


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Initiated in 2013, DMDD has the ambitious goal of identifying all embryonic lethal knockout lines made at the Wellcome Trust Sanger institute, through their work as a major centre for creation of individual mouse gene knockouts. DMDD uses a combination of comprehensive 3D imaging, tissue histology, immunocytochemistry and transcriptomics to identify abnormalities in embryo and placental structure for each embryonic lethal line. All data is made freely available via this web site, enabling individual researchers to identify lines relevant to their own research. The DMDD programme is coordinating its work with similar international efforts through the umbrella of the International Mouse Phenotyping Consortium.


Countries that developed this resource United Kingdom

Created in 2013

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How to cite this record DMDD; Deciphering the Mechanisms of Developmental Disorders; DOI:; Last edited: Jan. 8, 2019, 1:22 p.m.; Last accessed: Jan 23 2022 12:13 p.m.

This record is maintained by rwilson

Record added: April 13, 2016, 5:28 p.m.
Record updated: Jan. 8, 2019, 1:22 p.m. by The FAIRsharing Team.



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Deciphering the mechanisms of developmental disorders: phenotype analysis of embryos from mutant mouse lines.

Wilson R,McGuire C,Mohun T
Nucleic Acids Res 2015

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  • This record is maintained by rwilson