Protein Protein Interaction Inhibition Database
Abbreviation:2P2Idb
General Information
2P2Idb is a hand-curated structural database dedicated to the modulation of protein-protein interactions (PPIs).
It includes all interactions for which both the protein-protein and protein-modulator complexes have been structurally characterized by X-ray or NMR. The 2P2I database currently contains 14 protein-protein complexes, 16 free proteins, 56 protein-ligand complexes and 53 small molecule inhibitors. Only inhibitors found at the interface (orthosteric modulators) have been considered in this version of the database. The web server provides links to related sites of interest, binding affinity data, pre-calculated structural information about protein-protein interfaces and 3D interactive views through java applets.
How to cite this record
FAIRsharing.org: 2P2Idb; Protein Protein Interaction Inhibition Database; DOI: https://doi.org/10.25504/FAIRsharing.pfes4f;
Last edited: Jan. 8, 2019, 1:15 p.m.; Last accessed: Jan 26 2021 3:05 a.m.
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Edits to 'https://fairsharing.org/FAIRsharing.pfes4f' by 'The FAIRsharing Team' at 05:31, 05 Dec 2016 (approved):
'description' has been modified:
Before: 2P2Idb is a hand-curated structural database dedicated to the modulation of protein-protein interactions (PPIs). It includes all interactions for which both the protein-protein and protein-modulator complexes have been structurally characterized by X-ray or NMR. The 2P2I database currently contains 14 protein-protein complexes|16 free proteins|56 protein-ligand complexes and 53 small molecule inhibitors. Only inhibitors found at the interface (orthosteric modulators) have been considered in this version of the database. The web server provides links to related sites of interest|binding affinity data|pre-calculated structural information about protein-protein interfaces and 3D interactive views through java applets. An original tool (2P2Iinspector) is proposed to calculate|from a 3D structure|a series of parameters that characterize proteinprotein interfaces. A large range of biophysical and geometrical descriptors are computed including|buried accessible surface area|gap volume|non-bonded contacts|hydrogen-bonds|atom and residue composition|number of segments and secondary structure contribution. We also propose a qualitative scoring function to assess the druggability of PPIs. Users can compare parameters from their own protein-protein interface to a distribution of parameters from the 2P2Idb dataset. A qualitative score is given for each parameter and a color coded table provides the deviation of each parameter compared to the mean of the same parameter in the equivalent 2P2I cluster.
After: 2P2Idb is a hand-curated structural database dedicated to the modulation of protein-protein interactions (PPIs). It includes all interactions for which both the protein-protein and protein-modulator complexes have been structurally characterized by X-ray or NMR. The 2P2I database currently contains 14 protein-protein complexes|16 free proteins|56 protein-ligand complexes and 53 small molecule inhibitors. Only inhibitors found at the interface (orthosteric modulators) have been considered in this version of the database. The web server provides links to related sites of interest|binding affinity data|pre-calculated structural information about protein-protein interfaces and 3D interactive views through java applets.
Access / Retrieve Data
Conditions of Use
Data Curation
manual curation
|
No link recorded |
Data Access
Publications
2P2Idb: a structural database dedicated to orthosteric modulation of protein-protein interactions.
Basse MJ,Betzi S,Bourgeas R,Bouzidi S,Chetrit B,Hamon V,Morelli X,Roche P
Nucleic Acids Res 2012
View Paper (PubMed)
View Publication
Atomic analysis of protein-protein interfaces with known inhibitors: the 2P2I database.
Bourgeas R,Basse MJ,Morelli X,Roche P
PLoS One 2010
View Paper (PubMed)
View Publication
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