UniProt Knowledgebase

Abbreviation:UniProtKB

Recommended

General Information

The UniProt Knowledgebase (UniProtKB) is the central hub for the collection of functional information on proteins, with accurate, consistent and rich annotation. In addition to capturing the core data mandatory for each UniProtKB entry (mainly, the amino acid sequence, protein name or description, taxonomic data and citation information), as much annotation information as possible is added. This includes widely accepted biological ontologies, classifications and cross-references, and clear indications of the quality of annotation in the form of evidence attribution of experimental and computational data. The UniProt Knowledgebase consists of two sections: a reviewed section containing manually-annotated records with information extracted from literature and curator-evaluated computational analysis (aka "UniProtKB/Swiss-Prot"), and an unreviewed section with computationally analyzed records that await full manual annotation (aka "UniProtKB/TrEMBL").

Homepage http://www.uniprot.org/uniprot/

Countries that developed this resource Switzerland , United Kingdom , United States

Created in 2002

Taxonomic range

All

Knowledge Domains

Subjects

In the following recommendations:

Genetics & Genomics Next

How to cite this record FAIRsharing.org: UniProtKB; UniProt Knowledgebase; DOI: https://doi.org/10.25504/FAIRsharing.s1ne3g; Last edited: March 6, 2019, 12:52 p.m.; Last accessed: Apr 26 2019 5:49 p.m.

Publication for citation UniProt: the universal protein knowledgebase. ; Nucleic Acids Res ; 2016; 10.1093/nar/gkw1099;

This record is maintained by uniprot

Record updated: March 1, 2019, 5 p.m. by The FAIRsharing Team.

Show edit history

Edits to 'https://fairsharing.org/FAIRsharing.s1ne3g' by 'The FAIRsharing Team' at 17:00, 01 Mar 2019 (approved):

	'supportLinks' has been modified:
		Before:
			FAQ|https://www.uniprot.org/help/?fil=section:faq
			contact form|https://www.uniprot.org/contact
			online documentation|http://www.uniprot.org/help/
			tess training|https://tess.elixir-europe.org/materials/a-critical-guide-to-uniprotkb
			twitter|@uniprot
		After:
			FAQ|https://www.uniprot.org/help/?fil=section:faq
			TeSS training|https://tess.elixir-europe.org/materials/a-critical-guide-to-uniprotkb
			contact form|https://www.uniprot.org/contact
			online documentation|http://www.uniprot.org/help/
			training|https://www.youtube.com/channel/UCkCR5RJZCZZoVTQzTYY92aw
			twitter|@uniprot
		Added:
			TeSS training|https://tess.elixir-europe.org/materials/a-critical-guide-to-uniprotkb
			training|https://www.youtube.com/channel/UCkCR5RJZCZZoVTQzTYY92aw
		Removed:
			tess training|https://tess.elixir-europe.org/materials/a-critical-guide-to-uniprotkb

Edits to 'https://fairsharing.org/FAIRsharing.s1ne3g' by 'The FAIRsharing Team' at 16:56, 01 Mar 2019 (approved):

	'supportLinks' has been modified:
		Before:
			FAQ|https://www.uniprot.org/help/?fil=section:faq
			online documentation|http://www.uniprot.org/help/
			twitter|@uniprot
		After:
			FAQ|https://www.uniprot.org/help/?fil=section:faq
			contact form|https://www.uniprot.org/contact
			online documentation|http://www.uniprot.org/help/
			tess training|https://tess.elixir-europe.org/materials/a-critical-guide-to-uniprotkb
			twitter|@uniprot
		Added:
			contact form|https://www.uniprot.org/contact
			tess training|https://tess.elixir-europe.org/materials/a-critical-guide-to-uniprotkb
		Removed:

	'tools' has been modified:
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			BLAST||http://www.uniprot.org/blast/
			SPARQL Endpoint||https://sparql.uniprot.org
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			SPARQL Endpoint||https://sparql.uniprot.org
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			BLAST||http://www.uniprot.org/blast/

	'dataProcesses' has been modified:
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			Biocuration
			Download
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			Browse
			BLAST
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			Web interface

Edits to 'https://fairsharing.org/FAIRsharing.s1ne3g' by 'The FAIRsharing Team' at 16:47, 01 Mar 2019 (approved):

	'onto_disciplines' has been modified:
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			Life Sciences
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			Functional Genomics
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			Functional Genomics
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	'onto_domains' has been modified:
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			Annotation
			protein
			proteome
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			Annotation
			Biocuration
			Function analysis
			Gene expression data
			Gene functional annotation
			Protein Binding Domain
			Protein sequence
			Sequence annotation
			Sequence similarity
			cellular_component
			literature curation
			protein
			proteome
			structure
		Added:
			Biocuration
			Function analysis
			Gene expression data
			Gene functional annotation
			Protein Binding Domain
			Protein sequence
			Sequence annotation
			Sequence similarity
			cellular_component
			literature curation
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Edits to 'https://fairsharing.org/FAIRsharing.s1ne3g' by 'The FAIRsharing Team' at 16:50, 26 Feb 2019 (approved):

	'publications' has been modified:
		Before:
			UniProt: a hub for protein information|The UniProt Consortium|Nucleic Acids Res.|2015
			UniProt: the universal protein knowledgebase.||Nucleic Acids Res|2016
		After:
			UniProt: a hub for protein information|The UniProt Consortium|Nucleic Acids Res.|2015
			UniProt: the universal protein knowledgebase.||Nucleic Acids Res|2016
			UniProt: a worldwide hub of protein knowledge.||Nucleic Acids Res|2018
			UniProt: the universal protein knowledgebase.|UniProt Consortium T|Nucleic Acids Res|2018
			UniProt: the universal protein knowledgebase.||Nucleic Acids Res|2016
			UniProt Tools.|Pundir S,Martin MJ,O'Donovan C|Curr Protoc Bioinformatics|2016
			Activities at the Universal Protein Resource (UniProt).||Nucleic Acids Res|2013
			Update on activities at the Universal Protein Resource (UniProt) in 2013.||Nucleic Acids Res|2012
			The UniProt-GO Annotation database in 2011.|Dimmer EC,Huntley RP,Alam-Faruque Y,Sawford T,O'Donovan C,Martin MJ,Bely B,Browne P,Mun Chan W,Eberhardt R,Gardner M,Laiho K,Legge D,Magrane M,Pichler K,Poggioli D,Sehra H,Auchincloss A,Axelsen K,Blatter MC,Boutet E,Braconi-Quintaje S,Breuza L,Bridge A,Coudert E,Estreicher A,Famiglietti L,Ferro-Rojas S,Feuermann M,Gos A,Gruaz-Gumowski N,Hinz U,Hulo C,James J,Jimenez S,Jungo F,Keller G,Lemercier P,Lieberherr D,Masson P,Moinat M,Pedruzzi I,Poux S,Rivoire C,Roechert B,Schneider M,Stutz A,Sundaram S,Tognolli M,Bougueleret L,Argoud-Puy G,Cusin I,Duek-Roggli P,Xenarios I,Apweiler R|Nucleic Acids Res|2011
			UniProt Knowledgebase: a hub of integrated protein data.|Magrane M|Database (Oxford)|2011
			The Universal Protein Resource (UniProt) in 2010.||Nucleic Acids Res|2009
			The Universal Protein Resource (UniProt) 2009.||Nucleic Acids Res|2008
			The universal protein resource (UniProt).||Nucleic Acids Res|2007
			UniProtKB/Swiss-Prot.|Boutet E,Lieberherr D,Tognolli M,Schneider M,Bairoch A|Methods Mol Biol|2008
			The Universal Protein Resource (UniProt): an expanding universe of protein information.|Wu CH,Apweiler R,Bairoch A,Natale DA,Barker WC,Boeckmann B,Ferro S,Gasteiger E,Huang H,Lopez R,Magrane M,Martin MJ,Mazumder R,O'Donovan C,Redaschi N,Suzek B|Nucleic Acids Res|2005
			The Universal Protein Resource (UniProt).|Bairoch A,Apweiler R,Wu CH,Barker WC,Boeckmann B,Ferro S,Gasteiger E,Huang H,Lopez R,Magrane M,Martin MJ,Natale DA,O'Donovan C,Redaschi N,Yeh LS|Nucleic Acids Res|2004
			UniProt archive.|Leinonen R,Diez FG,Binns D,Fleischmann W,Lopez R,Apweiler R|Bioinformatics|2004
			The SWISS-PROT protein sequence database: its relevance to human molecular medical research.|Bairoch A,Apweiler R|J Mol Med (Berl)|1997
		Added:
			UniProt: a worldwide hub of protein knowledge.||Nucleic Acids Res|2018
			UniProt: the universal protein knowledgebase.|UniProt Consortium T|Nucleic Acids Res|2018
			UniProt Tools.|Pundir S,Martin MJ,O'Donovan C|Curr Protoc Bioinformatics|2016
			Activities at the Universal Protein Resource (UniProt).||Nucleic Acids Res|2013
			Update on activities at the Universal Protein Resource (UniProt) in 2013.||Nucleic Acids Res|2012
			The UniProt-GO Annotation database in 2011.|Dimmer EC,Huntley RP,Alam-Faruque Y,Sawford T,O'Donovan C,Martin MJ,Bely B,Browne P,Mun Chan W,Eberhardt R,Gardner M,Laiho K,Legge D,Magrane M,Pichler K,Poggioli D,Sehra H,Auchincloss A,Axelsen K,Blatter MC,Boutet E,Braconi-Quintaje S,Breuza L,Bridge A,Coudert E,Estreicher A,Famiglietti L,Ferro-Rojas S,Feuermann M,Gos A,Gruaz-Gumowski N,Hinz U,Hulo C,James J,Jimenez S,Jungo F,Keller G,Lemercier P,Lieberherr D,Masson P,Moinat M,Pedruzzi I,Poux S,Rivoire C,Roechert B,Schneider M,Stutz A,Sundaram S,Tognolli M,Bougueleret L,Argoud-Puy G,Cusin I,Duek-Roggli P,Xenarios I,Apweiler R|Nucleic Acids Res|2011
			UniProt Knowledgebase: a hub of integrated protein data.|Magrane M|Database (Oxford)|2011
			The Universal Protein Resource (UniProt) in 2010.||Nucleic Acids Res|2009
			The Universal Protein Resource (UniProt) 2009.||Nucleic Acids Res|2008
			The universal protein resource (UniProt).||Nucleic Acids Res|2007
			UniProtKB/Swiss-Prot.|Boutet E,Lieberherr D,Tognolli M,Schneider M,Bairoch A|Methods Mol Biol|2008
			The Universal Protein Resource (UniProt): an expanding universe of protein information.|Wu CH,Apweiler R,Bairoch A,Natale DA,Barker WC,Boeckmann B,Ferro S,Gasteiger E,Huang H,Lopez R,Magrane M,Martin MJ,Mazumder R,O'Donovan C,Redaschi N,Suzek B|Nucleic Acids Res|2005
			The Universal Protein Resource (UniProt).|Bairoch A,Apweiler R,Wu CH,Barker WC,Boeckmann B,Ferro S,Gasteiger E,Huang H,Lopez R,Magrane M,Martin MJ,Natale DA,O'Donovan C,Redaschi N,Yeh LS|Nucleic Acids Res|2004
			UniProt archive.|Leinonen R,Diez FG,Binns D,Fleischmann W,Lopez R,Apweiler R|Bioinformatics|2004
			The SWISS-PROT protein sequence database: its relevance to human molecular medical research.|Bairoch A,Apweiler R|J Mol Med (Berl)|1997
		Removed:

Edits to 'https://fairsharing.org/FAIRsharing.s1ne3g' by 'The FAIRsharing Team' at 10:48, 10 Jan 2019 (approved):

	'publications' has been modified:
		Before:
			UniProt: a hub for protein information|The UniProt Consortium|Nucleic Acids Res.|2015
		After:
			UniProt: a hub for protein information|The UniProt Consortium|Nucleic Acids Res.|2015
			UniProt: the universal protein knowledgebase.||Nucleic Acids Res|2016
		Added:
			UniProt: the universal protein knowledgebase.||Nucleic Acids Res|2016
		Removed:

Edits to 'https://fairsharing.org/FAIRsharing.s1ne3g' by 'The FAIRsharing Team' at 11:17, 19 Jul 2018 (approved):

	'deprecation_reason' has been modified:
		Before: None
		After: None

In Collections

Data Citation Implementation

Open Science Prize

International Molecular Exchange Consortium (IMEx)

ELIXIR Core Data Resources and Deposition Databases

Support

General

FAQ	https://www.uniprot.org/help/?fil=sectio ...
contact form	Contact
online documentation	http://www.uniprot.org/help/
training	Youtube channel
twitter	@uniprot

Additional Information

Contact	General contact
Identifiers.org	MIR:00000005

TeSS training resources

A Critical Guide to UniProtKB

Tools

SPARQL Endpoint

https://sparql.uniprot.org

Access / Retrieve Data

Conditions of Use

Applies to: Data use

Creative Commons Attribution 4.0 International (CC BY 4.0)

Data Curation

Biocuration

http://www.uniprot.org/help/biocuration

Data Access

Download	http://www.uniprot.org/downloads
Browse	https://www.uniprot.org/uniprot/
Text search	https://www.uniprot.org/uniprot/
BLAST	http://www.uniprot.org/blast/

REST Web Services

REST API

https://www.uniprot.org/help/api

Other Web Services

Java remote API

https://www.ebi.ac.uk/uniprot/japi/index.html

Publications

UniProt: a hub for protein information

The UniProt Consortium
Nucleic Acids Res. 2015