Functional Therapeutic Chemical Classification System

Abbreviation: FTC

General Information

The Functional Therapeutic Chemical Classification System (FTC) defines over 20,000 mechanisms and modes of action for approved drugs. The resource abstracts away from the traditional chemical structure-based approach and focuses solely on the mode of action of drugs. The classification sorts therapeutic agents based on their function in the human body. Please note that this resource is no longer actively maintained (source: https://github.com/loopasam/ftc/issues/1).

Homepage https://github.com/loopasam/ftc

Countries that developed this resource Austria , Belgium , Croatia , Czech Republic , Denmark , Finland , France , Germany , Greece , Hungary , Iceland , Israel , Italy , Lithuania , Luxembourg , Malta , Montenegro , Netherlands , Norway , Portugal , Republic of Ireland , Slovakia , Spain , Sweden , Switzerland , United Kingdom

Created in 2016

Taxonomic range

All

Knowledge Domains

User-defined Tags

Approved drug

Drug repositioning

How to cite this record FAIRsharing.org: FTC; Functional Therapeutic Chemical Classification System; DOI: https://doi.org/10.25504/FAIRsharing.spjjv8; Last edited: Feb. 12, 2020, 7:47 p.m.; Last accessed: Feb 23 2020 2:23 p.m.

Publication for citation The functional therapeutic chemical classification system. Croset S,Overington JP,Rebholz-Schuhmann D; Bioinformatics ; 2013; 10.1093/bioinformatics/btt628;

Record added: Oct. 24, 2017, 9:41 a.m.
Record updated: Feb. 12, 2020, 7:47 p.m. by The FAIRsharing Team.

Show edit history

Edits to 'https://fairsharing.org/FAIRsharing.spjjv8' by 'The FAIRsharing Team' at 19:47, 12 Feb 2020 (approved):

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		Before: The Functional Therapeutic Chemical Classification System (FTC) defines over 20,000 mechanisms and modes of action for approved drugs. The resource abstracts away from the traditional chemical structure-based approach and focuses solely on the mode of action of drugs. The classification sorts therapeutic agents based on their function in the human body. Please note that this resource is no longer actively maintained, although not actively deprecated as the GitHub project remains.
		After: The Functional Therapeutic Chemical Classification System (FTC) defines over 20,000 mechanisms and modes of action for approved drugs. The resource abstracts away from the traditional chemical structure-based approach and focuses solely on the mode of action of drugs. The classification sorts therapeutic agents based on their function in the human body. Please note that this resource is no longer actively maintained (source: https://github.com/loopasam/ftc/issues/1).

Edits to 'https://fairsharing.org/FAIRsharing.spjjv8' by 'The FAIRsharing Team' at 19:45, 12 Feb 2020 (approved):

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			European Molecular Biology Laboratory (EMBL), Heidelberg, Germany|http://www.embl.org|Funds
			European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridgeshire, UK|https://www.ebi.ac.uk/|Maintains
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			European Molecular Biology Laboratory (EMBL), Heidelberg, Germany|http://www.embl.org|Funds
			European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridgeshire, UK|https://www.ebi.ac.uk/|Maintains
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			forum|https://github.com/loopasam/ftc/issues
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	'description' has been modified:
		Before: The Functional Therapeutic Chemical Classification System (FTC) defines over 20'000 mechanisms and modes of action for approuved drugs. The resource abstracts away from the traditional chemical structure-based approach and focuses solely on the mode of action of drugs. The classification sorts therapeutic agents based on their function in the human body.
		After: The Functional Therapeutic Chemical Classification System (FTC) defines over 20,000 mechanisms and modes of action for approved drugs. The resource abstracts away from the traditional chemical structure-based approach and focuses solely on the mode of action of drugs. The classification sorts therapeutic agents based on their function in the human body. Please note that this resource is no longer actively maintained, although not actively deprecated as the GitHub project remains.

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			Austria
			Belgium
			Croatia
			Czech Republic
			Denmark
			Finland
			France
			Germany
			Greece
			Hungary
			Iceland
			Israel
			Italy
			Lithuania
			Luxembourg
			Malta
			Montenegro
			Netherlands
			Norway
			Portugal
			Republic of Ireland
			Slovakia
			Spain
			Sweden
			Switzerland
			United Kingdom
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			Austria
			Belgium
			Croatia
			Czech Republic
			Denmark
			Finland
			France
			Germany
			Greece
			Hungary
			Iceland
			Israel
			Italy
			Lithuania
			Luxembourg
			Malta
			Montenegro
			Netherlands
			Norway
			Portugal
			Republic of Ireland
			Slovakia
			Spain
			Sweden
			Switzerland
			United Kingdom
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			Apache License 2.0|http://www.apache.org/licenses/LICENSE-2.0|Software
			Creative Commons Attribution 3.0 Unported (CC BY 3.0)|https://creativecommons.org/licenses/by/3.0/|Data
			EBI Terms of Use|http://www.ebi.ac.uk/about/terms-of-use|Data
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			Apache License 2.0|http://www.apache.org/licenses/LICENSE-2.0|Software
			Creative Commons Attribution 3.0 Unported (CC BY 3.0)|https://creativecommons.org/licenses/by/3.0/|Data
			EBI Terms of Use|http://www.ebi.ac.uk/about/terms-of-use|Data
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			Gene Ontology
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			Classification
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			Approved drug
			Drug repositioning
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			Approved drug
			Drug repositioning
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			Download (OBO)
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			The functional therapeutic chemical classification system.|Croset S,Overington JP,Rebholz-Schuhmann D|Bioinformatics|2013
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			The functional therapeutic chemical classification system.|Croset S,Overington JP,Rebholz-Schuhmann D|Bioinformatics|2013
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Support

General

forum

GitHub Issue Tracker

Additional Information

Contact

Samuel Croset

External Links

Bioportal

http://bioportal.bioontology.org/ontologies/FTC

Tools

No tools defined

Schemas

No XSD schemas defined

Access / Retrieve Data

Conditions of Use

Applies to: Data use

Applies to: Database software

Apache License 2.0

Data Release

Download (OBO)	https://github.com/loopasam/ftc/raw/master/public/data/ftc-kb-full.obo
Download (OWL)	https://github.com/loopasam/ftc/blob/master/public/data/ftc-kb-full.ow ...

Publications

The functional therapeutic chemical classification system.

Croset S,Overington JP,Rebholz-Schuhmann D
Bioinformatics 2013

View Paper (PubMed) View Publication

FTC Ontology Display

View in BioPortal.

Disclaimer: This widget assumes the availability of the ontology resources in the NCBO BioPortal.

Related Standards

Reporting Guidelines

No guidelines defined

Terminology Artifacts

Gene Ontology

Models and Formats

Identifier Schemas

No identifier schema standards defined

Metrics

No metrics standards defined

Implementing Databases (3)

ChEMBL
ChEMBL is an open large-scale bioactivity database containing information largely manually extracted from the medicinal chemistry literature. Information regarding the compounds tested (including their structures), the biological or physicochemical assays performed on these and the targets of these assays are recorded in a structured form, allowing users to address a broad range of drug discovery questions.

DrugBank
The DrugBank database is a freely available bioinformatics and chemoinformatics resource that combines detailed drug (i.e. chemical, pharmacological and pharmaceutical) data with comprehensive drug target (i.e. sequence, structure, and pathway) information.

UniProt Knowledgebase
The UniProt Knowledgebase (UniProtKB) is the central hub for the collection of functional information on proteins, with accurate, consistent and rich annotation. In addition to capturing the core data mandatory for each UniProtKB entry (mainly, the amino acid sequence, protein name or description, taxonomic data and citation information), as much annotation information as possible is added. This includes widely accepted biological ontologies, classifications and cross-references, and clear indications of the quality of annotation in the form of evidence attribution of experimental and computational data. The UniProt Knowledgebase consists of two sections: a reviewed section containing manually-annotated records with information extracted from literature and curator-evaluated computational analysis (aka "UniProtKB/Swiss-Prot"), and an unreviewed section with computationally analyzed records that await full manual annotation (aka "UniProtKB/TrEMBL").

Implementing Policies

This record is not implemented by any policy.

Credit

Record Maintainer

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Funds

European Molecular Biology Laboratory (EMBL), Heidelberg, Germany (Research institute)

Maintains

European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridgeshire, UK (Research institute) Lead

Functional Therapeutic Chemical Classification System

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