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Drug Target Ontology

Abbreviation: DTO

General Information

Drug Target Ontology (DTO) is developed as a reference for drug targets with the longer-term goal to create a community standard that will facilitate the integration of diverse drug discovery information from numerous heterogeneous resources. The first version of the DTO consists of asserted class hierarchies of the four IDG protein families, GPCRs, kinases, ion channels, and nuclear hormone receptors. Protein classes are linked to tissue and disease via different levels of confidence. DTO also contains drug target development classifications, a large collection of cell lines from the LINCS project and relevant cell-disease and cell-tissue relations. DTO is modeled in OWL2-DL to enable further classification by inference reasoning and SPARQL queries. DTO is implemented following a modularization approach. DTO will serve as the organizational framework for drug targets in the IDG PHAROS User Interface Portal (https://pharos.nih.gov).

Homepage http://drugtargetontology.org/

Countries that developed this resource United States

Created in 2015

Taxonomic range

All

Knowledge Domains

Subjects

User-defined Tags

Drug Target

How to cite this record FAIRsharing.org: DTO; Drug Target Ontology; DOI: https://doi.org/10.25504/FAIRsharing.tke3y2; Last edited: July 13, 2021, 8:52 p.m.; Last accessed: Oct 24 2021 11:11 p.m.

Record added: Oct. 24, 2017, 9:41 a.m.
Record updated: July 9, 2021, 4:04 p.m. by The FAIRsharing Team.

Show edit history

Edits to 'https://fairsharing.org/FAIRsharing.tke3y2' by 'The FAIRsharing Team' at 16:04, 09 Jul 2021 (approved):

'description' has been modified:
Before: Drug Target Ontology (TDO) is developed as a reference for drug targets with the longer-term goal to create a community standard that will facilitate the integration of diverse drug discovery information from numerous heterogeneous resources. The first version of the DTO consists of asserted class hierarchies of the four IDG protein families, GPCRs, kinases, ion channels, and nuclear hormone receptors. Protein classes are linked to tissue and disease via different levels of confidence. DTO also contains drug target development classifications, a large collection of cell lines from the LINCS project and relevant cell-disease and cell-tissue relations. DTO is modeled in OWL2-DL to enable further classification by inference reasoning and SPARQL queries. DTO is implemented following a modularization approach. DTO will serve as the organizational framework for drug targets in the IDG PHAROS User Interface Portal (https://pharos.nih.gov).
After: Drug Target Ontology (DTO) is developed as a reference for drug targets with the longer-term goal to create a community standard that will facilitate the integration of diverse drug discovery information from numerous heterogeneous resources. The first version of the DTO consists of asserted class hierarchies of the four IDG protein families, GPCRs, kinases, ion channels, and nuclear hormone receptors. Protein classes are linked to tissue and disease via different levels of confidence. DTO also contains drug target development classifications, a large collection of cell lines from the LINCS project and relevant cell-disease and cell-tissue relations. DTO is modeled in OWL2-DL to enable further classification by inference reasoning and SPARQL queries. DTO is implemented following a modularization approach. DTO will serve as the organizational framework for drug targets in the IDG PHAROS User Interface Portal (https://pharos.nih.gov).

Edits to 'https://fairsharing.org/FAIRsharing.tke3y2' by 'The FAIRsharing Team' at 13:49, 02 Mar 2021 (approved):

	'grants' has been modified:
		Before:
			U54CA189205 (Illuminating the Druggable Genome Knowledge Management Center; Tudor Oprea, PI)
		After:
			U54CA189205 (Illuminating the Druggable Genome Knowledge Management Center; Tudor Oprea; PI)
		Added:
			U54CA189205 (Illuminating the Druggable Genome Knowledge Management Center; Tudor Oprea; PI)
		Removed:
			U54CA189205 (Illuminating the Druggable Genome Knowledge Management Center; Tudor Oprea, PI)

Edits to 'https://fairsharing.org/FAIRsharing.tke3y2' by 'The FAIRsharing Team' at 11:19, 24 Feb 2021 (approved):

	'grants' has been modified:
		Before:
			U54CA189205 (Illuminating the Druggable Genome Knowledge Management Center, Tudor Oprea, PI)
		After:
			U54CA189205 (Illuminating the Druggable Genome Knowledge Management Center; Tudor Oprea, PI)
		Added:
			U54CA189205 (Illuminating the Druggable Genome Knowledge Management Center; Tudor Oprea, PI)
		Removed:
			U54CA189205 (Illuminating the Druggable Genome Knowledge Management Center, Tudor Oprea, PI)

	'miriam_id' has been modified:
		Before: None
		After:

Edits to 'https://fairsharing.org/FAIRsharing.tke3y2' by 'The FAIRsharing Team' at 11:28, 16 Jan 2018 (approved):

	'organizations' has been modified:
		Before:
			NIH Common Fund|Government body|Funds
			Center for Computational Science (CCS)|University of Miami|Miami|FL|USA|University|Maintains
			NIH Common Fund|USA|Government body|Funds
		After:
			NIH Common Fund|USA|Government body|Funds
			Center for Computational Science (CCS)|University of Miami|Miami|FL|USA|University|Maintains
		Added:
		Removed:
			NIH Common Fund|Government body|Funds

Edits to 'https://fairsharing.org/FAIRsharing.tke3y2' by 'The FAIRsharing Team' at 11:22, 16 Jan 2018 (approved):

	'miriam_url' has been modified:
		Before: None
		After:

In Collections

Chemistry

Support

General

contact form	Contact Form
online documentation	Introcuction to DTO in Pharos
online documentation	GitHub repository

Additional Information

Contact

Stephan Schurer

External Links

Bioportal

http://bioportal.bioontology.org/ontologies/DTO

Tools

No tools defined

Schemas

No XSD schemas defined

Access / Retrieve Data

Conditions of Use

Applies to: Data use

Creative Commons Attribution 3.0 Unported (CC BY 3.0)

Data Access

Viewer

http://drugtargetontology.org/viewer.html

Publications

Drug target ontology to classify and integrate drug discovery data.

Lin Y,Mehta S,Kucuk-McGinty H,Turner JP,Vidovic D,Forlin M,Koleti A,Nguyen DT,Jensen LJ,Guha R,Mathias SL,Ursu O,Stathias V,Duan J,Nabizadeh N,Chung C,Mader C,Visser U,Yang JJ,Bologa CG,Oprea TI,Schurer SC
J Biomed Semantics 2017

View Paper (PubMed) View Publication

DTO Ontology Display

View in BioPortal.

Disclaimer: This widget assumes the availability of the ontology resources in the NCBO BioPortal.

Related Standards

Reporting Guidelines

No guidelines defined

Terminology Artifacts

No semantic standards defined

Models and Formats

Web Ontology Language

Identifier Schemas

No identifier schema standards defined

Metrics

No metrics standards defined

Related Databases (1)

Target Central Resource Database
TCRD is the central resource behind the Illuminating the Druggable Genome Knowledge Management Center (IDG-KMC). TCRD contains information about human targets, with special emphasis on four families of targets that are central to the NIH IDG initiative: GPCRs, kinases, ion channels and nuclear receptors. Olfactory GPCRs (oGPCRs) are treated as a separate family. A key aim of the KMC is to classify the development/druggability level of targets. The official public portal for TCRD is Pharos (pharos.nih.gov). Based on modern web design principles the Pharos interface provides facile access to all data types collected by the KMC. Given the complexity of the data surrounding any target, efficient and intuitive visualization has been a high priority, to enable users to quickly navigate & summarize search results and rapidly identify patterns. A critical feature of the interface is the ability to perform flexible search and subsequent drill down of search results. Underlying the interface is a RESTful API that provides programmatic access to all KMC data, allowing for easy consumption in user applications.

Implementing Policies

This record is not implemented by any policy.

Credit

Record Maintainer