Minimum Information About a Spinal Cord Injury experiment
How to cite this record FAIRsharing.org: MIASCI; Minimum Information About a Spinal Cord Injury experiment; DOI: https://doi.org/10.25504/FAIRsharing.wz1w7t; Last edited: Jan. 8, 2019, 1:27 p.m.; Last accessed: Jun 21 2021 9:13 p.m.
Record updated: March 28, 2017, 12:16 p.m. by vlemmon1951.
Edits to 'https://fairsharing.org/FAIRsharing.wz1w7t' by 'The FAIRsharing Team' at 22:18, 30 Nov 2016 (approved): 'description' has been modified: Before: Although many millions of dollars have been spent on research related to spinal cord injury over the past 20 years there are no reliable treatments to improve regeneration. Scientists in this area have made substantial efforts to standardize experimental methodologies. For example, consortiums have developed standardized reporting systems for human SCI studies (Biering-Sorensen et al., 2011), standardized injury devices, such as the NYU impactor (Young, 2002), and standardized outcome measures, such as the BBB Locomotor Rating Scale to quantify recovery of movement after SCI in rats (Basso et al., 1995). Minimum Information for Biological and Biomedical Investigations (MIBBI) facilitate communicating methods and results (Taylor et al., 2008). Developing standards for Minimum Information about a Animal Spinal Cord Injury Experiment (MIASCI) would facilitate bioinformatic efforts and allow investigators to more accurately replicate and extend studies. A paper on MIASCI was published in J Neurotrauma in May 2014 (PMID 24870067). The 1.0 version of MIASCI is available at https://sourceforge.net/projects/miasci/ An annotation tool|based on IsaTab|is in development. After: Standards for Minimum Information about a Animal Spinal Cord Injury Experiment (MIASCI) facilitates bioinformatic efforts and allow investigators to more accurately replicate and extend studies.
Edits to 'https://fairsharing.org/FAIRsharing.wz1w7t' by 'The FAIRsharing Team' at 16:26, 01 Aug 2016 (approved): 'homepage' has been modified: Before: https://sourceforge.net/projects/miasci/ After: http://www.regenbase.org/miasci-online.html
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Minimum Information About a Spinal Cord Injury Experiment (MIASCI) - a proposed reporting standard for spinal cord injury experiments.
Lemmon VP, Ferguson AR, Popovich PG, Xu XM, Snow DM, Igarashi M, Beattie CE, Bixby JL, Abeyruwan SW, Beattie MS, Bethea J, Bradke F, Bresnahan JC, Bunge MB, Callahan A, David S, Dunlop SA, Fawcett J, Fehlings M, Fischer I, Giger RJ, Goshima Y, Grimpe B, Hagg T, Hall ED, Harrison BJ, Harvey AR, He C, He Z, Hirata T, Hoke A, Hulsebosch CE, Hurtado A, Jain A, Kadoya K, Kamiguchi H, Kengaku M, Kocsis JD Ph D, Kwon BK, Lee JK, Liebl DJ PhD, Liu SJ, Lowery LA, Mandrekar-Colucci S, Martin JH, Mason CA, McTigue DM, Mokarram N, Moon LD, Muller HW, Nakamura T, Namba T, Nishibe M, Oinuma I, Oudega M, Pleasure DE, Raisman G, Rasband MN, Reier PJ, Santiago-Medina M, Schwab JM, Schwab ME, Shinmyo Y, Silver J, Smith GM, So KF, Sofroniew MV Md PhD, Strittmatter SM, Tuszynski MH, Twiss JL, Visser U, Watkins TA, Wu W, Yoon SO, Yuzaki M, Zheng B, Zhou F, Zou Y.
Journal of Neurotrauma 2014
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RegenBase is a knowledge base of SCI biology. RegenBase integrates curated literature-sourced facts and experimental details from publications, raw assay data profiling the effect of compounds on enzyme activity and cell growth, and structured SCI domain knowledge in the form of the first ontology for SCI, using Semantic Web representation languages and frameworks. RegenBase enables researchers to organize and interrogate experimental data generated by spinal cord injury (SCI) research, with the ultimate goal of translating SCI experimental findings in model organisms into human therapies.
Open Data Commons for Spinal Cord Injury
The Open Data Commons for Spinal Cord Injury is a cloud-based community-driven repository to store, share, and publish spinal cord injury research data. There are several challenges for scientific reproducibility and bench-to-bedside translation. For example, only research and data that are published actually get disseminated, a phenomenon known as publication bias. Published research reflects to only a small fraction of all data collected, and data that do not lead to publication are largely ignored, hidden away in filing cabinets and hard drives. This results in an abundance of inaccessible scientific data known as “dark data”. Even when research is disseminated, it is usually in the form of summary reports of aggregated data (e.g. averages across individual subjects) such as scientific articles. The fact that the individual subject-level data are inaccessible further contributes to dark data. The spinal cord injury (SCI) community created the ODC-SCI to mitigate dark data in SCI research. The ODC-SCI also aims to increase transparency with individual-level data, enhance collaboration, facilitate advanced analytics, and conform to increasing mandates by funders and publishers to make data accessible. Members of the ODC-SCI have access to a private digital lab space managed by the PI or multi-PIs for dataset storage and sharing. The PIs can share their labs’ datasets with the registered members of the ODC-SCI community and make their datasets public and citable. The ODC-SCI implements stewardship principles that scientific data be made FAIR (Findable, Accessible, Interoperable and Reusable) and has been widely adopted by the international SCI research community.
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U.S. National Library of Medicine (Government body)
1R01 NS080145 (NINDS NIH)