standards > model/format > DOI:10.25504/FAIRsharing.zwjNAh


ready AIRR Rearrangement File Format

Abbreviation: AIRR TSV


General Information
Increased interest in the immune system's involvement in pathophysiological phenomena coupled with decreased DNA sequencing costs have led to an explosion of antibody and T cell receptor sequencing data collectively termed "adaptive immune receptor repertoire sequencing" (AIRR-seq or Rep-Seq). The AIRR Community has been actively working to standardize protocols, metadata, formats, APIs, and other guidelines to promote open and reproducible studies of the immune repertoire. In this paper, we describe the work of the AIRR Community's Data Representation Working Group to develop standardized data representations for storing and sharing annotated antibody and T cell receptor data. Our file format emphasizes ease-of-use, accessibility, scalability to large data sets, and a commitment to open and transparent science. It is composed of a tab-delimited format with a specific schema. Several popular repertoire analysis tools and data repositories already utilize this AIRR-seq data format. We hope that others will follow suit in the interest of promoting interoperable standards.

Homepage https://docs.airr-community.org/en/stable/datarep/overview.html

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Created in 2018

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How to cite this record FAIRsharing.org: AIRR TSV; AIRR Rearrangement File Format; DOI: https://doi.org/10.25504/FAIRsharing.zwjNAh; Last edited: July 31, 2020, 2:05 p.m.; Last accessed: Sep 30 2020 11:31 p.m.

Publication for citation  AIRR Community Standardized Representations for Annotated Immune Repertoires Vander Heiden JA, Marquez S, Marthandan N, Bukhari SAC, Busse CE, Corrie B, Hershberg U, Kleinstein SH, Matsen Iv FA, Ralph DK, Rosenfeld AM, Schramm CA; AIRR Community, Christley S, Laserson U; Frontiers in Immunology ; 2018; 10.3389/fimmu.2018.02206;


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Record added: April 29, 2020, 10:22 p.m.
Record updated: April 30, 2020, 7:53 a.m. by The FAIRsharing Team.

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AIRR Community Standardized Representations for Annotated Immune Repertoires

Vander Heiden JA, Marquez S, Marthandan N, Bukhari SAC, Busse CE, Corrie B, Hershberg U, Kleinstein SH, Matsen Iv FA, Ralph DK, Rosenfeld AM, Schramm CA; AIRR Community, Christley S, Laserson U
Frontiers in Immunology 2018

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Related Databases (2)
iReceptor Public Archive
A data repository for the storage and sharing of Adaptive Immune Receptor Repertoire data. Primary public repository for the iReceptor Platform and Scientific Gateway.

VDJServer
VDJServer is a free, scalable resource for performing immune repertoire analysis and sharing data.

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