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ready Therapeutic Structural Antibody Database


General Information
The Therapeutic Structural Antibody Database tracks all antibody- and nanobody-related therapeutics recognized by the World Health Organisation (WHO), and identifies any corresponding structures in the Structural Antibody Database (SAbDab) with near-exact or exact variable domain sequence matches. Thera-SAbDab is synchronized with SAbDab to update weekly, reflecting new Protein Data Bank entries and the availability of new sequence data published by the WHO. Each therapeutic summary page lists structural coverage (with links to the appropriate SAbDab entries), alignments showing where any near-matches deviate in sequence, and accompanying metadata, such as intended target and investigated conditions. Thera-SAbDab can be queried by therapeutic name, by a combination of metadata, or by variable domain sequence - returning all therapeutics that are within a specified sequence identity over a specified region of the query. The sequences of all therapeutics listed in Thera-SAbDab are downloadable as a single file with accompanying metadata.


Countries that developed this resource Germany , United Kingdom

Created in 2019

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How to cite this record Thera-SAbDab; Therapeutic Structural Antibody Database; DOI:; Last edited: Jan. 21, 2020, 11:02 a.m.; Last accessed: Dec 02 2021 7:06 p.m.

This record is maintained by mraybould

Record added: Dec. 31, 2019, 1:51 p.m.
Record updated: Jan. 21, 2020, 11:02 a.m. by mraybould.

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Thera-SAbDab: the Therapeutic Structural Antibody Database

Matthew IJ Raybould, Claire Marks, Alan P Lewis, Jiye Shi, Alexander Bujotzek, Bruck Taddese, Charlotte M Deane
Nucleic Acids Research 2019

View Paper (PubMed) View Publication

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  • EP/L016044/1 (Engineering and Physical Sciences Research Council (EPSRC), UK)