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ready Transporter Classification Database

Abbreviation:TCDB

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This freely accessible database details a comprehensive IUBMB approved classification system for membrane transport proteins known as the Transporter Classification (TC) system. The TC system is analogous to the Enzyme Commission (EC) system for classification of enzymes, except that it incorporates both functional and phylogenetic information for organisms of all types. As of April. 1, 2021, TCDB consists of 21,114 proteins classified in 16,558 non-redundant transport systems with 1,605 tabulated 3D structures, 19,196 reference citations describing 1,586 transporter families, of which 26% are members of 83 recognized superfamilies. Overall, this is an increase of over 50% since the last published update of the database in 2016. The most recent update of the database contents and features include (1) adoption of a chemical ontology for substrates of transporters, (2) inclusion of new superfamilies, (3) a domain-based characterization of transporter families (tcDoms) for the identification of new members as well as functional and evolutionary relationships between families, (4) development of novel software to facilitate curation and use of the database, (5) addition of new subclasses of transport systems including 11 novel types of channels and 3 types of group translocators, and (6) the inclusion of many man-made (artificial) transmembrane pores/channels and carriers.




How to cite this record FAIRsharing.org: TCDB; Transporter Classification Database; DOI: https://doi.org/10.25504/FAIRsharing.p3bzqb; Last edited: June 22, 2021, 11:57 a.m.; Last accessed: Oct 25 2021 11:52 a.m.

Publication for citation  The Transporter Classification Database (TCDB): 2021 update Saier MH, Reddy VS, Moreno-Hagelsieb G, Hendargo KJ, Zhang Y, Iddamsetty V, Lam KJK, Tian N, Russum S, Wang J, Medrano-Soto A.; Nucleic Acids Res. ; 2021; 10.1093/nar/gkaa1004 ;


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Record updated: June 2, 2021, 9:46 a.m. by The FAIRsharing Team.

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TCDB: the Transporter Classification Database for membrane transport protein analyses and information.

Saier MH., Tran CV., Barabote RD.,
Nucleic Acids Res. 2006

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The Transporter Classification Database: recent advances.

Saier MH., Yen MR., Noto K., Tamang DG., Elkan C.,
Nucleic Acids Res. 2009

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The transporter classification database

Saier MH, Reddy VS, Tamang DG, Vastermark A.
Nucleic Acids Res 2014

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The Transporter Classification Database (TCDB): recent advances

Saier MH, Reddy V S, Tsu BV, Ahmed MS, Li C, Moreno-Hagelsieb G.
Nucleic Acids Res 2016

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The Transporter Classification Database (TCDB): 2021 update

Saier MH, Reddy VS, Moreno-Hagelsieb G, Hendargo KJ, Zhang Y, Iddamsetty V, Lam KJK, Tian N, Russum S, Wang J, Medrano-Soto A.
Nucleic Acids Res. 2021

View Paper (PubMed) View Publication

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