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ready Protein Protein Interaction Inhibition Database


General Information
2P2Idb is a hand-curated structural database dedicated to the modulation of protein-protein interactions (PPIs). It includes all interactions for which both the protein-protein and protein-modulator complexes have been structurally characterized by X-ray or NMR. The 2P2I database currently contains 14 protein-protein complexes, 16 free proteins, 56 protein-ligand complexes and 53 small molecule inhibitors. Only inhibitors found at the interface (orthosteric modulators) have been considered in this version of the database. The web server provides links to related sites of interest, binding affinity data, pre-calculated structural information about protein-protein interfaces and 3D interactive views through java applets.


Countries that developed this resource France

Created in 2010

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How to cite this record 2P2Idb; Protein Protein Interaction Inhibition Database; DOI:; Last edited: Jan. 8, 2019, 1:15 p.m.; Last accessed: Nov 30 2021 3:15 a.m.

Record updated: Dec. 5, 2016, 2 p.m. by The FAIRsharing Team.

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2P2Idb: a structural database dedicated to orthosteric modulation of protein-protein interactions.

Basse MJ,Betzi S,Bourgeas R,Bouzidi S,Chetrit B,Hamon V,Morelli X,Roche P
Nucleic Acids Res 2012

View Paper (PubMed) View Publication

Atomic analysis of protein-protein interfaces with known inhibitors: the 2P2I database.

Bourgeas R,Basse MJ,Morelli X,Roche P
PLoS One 2010

View Paper (PubMed) View Publication

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Grant Number(s)

  • ANR-11-BS07-019-02 (National Agency of Research (ANR), Paris, France)