Rhea

Recommended

General Information

Rhea is a comprehensive and non-redundant resource of expert-curated chemical and transport reactions of biological interest. Rhea can be used for enzyme annotation, genome-scale metabolic modeling and omics-related analysis. Rhea describes enzyme-catalyzed reactions covering the IUBMB Enzyme Nomenclature list as well as additional reactions, including spontaneously occurring reactions. Rhea is built on ChEBI (Chemical Entities of Biological Interest) ontology of small molecules to describe its reaction participants. Since December 2018, Rhea is the standard for enzyme annotation in UniProt.

Homepage http://www.rhea-db.org

Countries that developed this resource Switzerland , United Kingdom

Created in 2009

Taxonomic range

All

Knowledge Domains

Subjects

In the following recommendations:

How to cite this record FAIRsharing.org: Rhea; Rhea; DOI: https://doi.org/10.25504/FAIRsharing.pn1sr5; Last edited: May 19, 2020, 3:36 p.m.; Last accessed: Apr 11 2021 1:33 p.m.

Publication for citation Updates in Rhea: SPARQLing biochemical reaction data. Lombardot T, Morgat A, Axelsen KB, Aimo L, Hyka-Nouspikel N, Niknejad A, Ignatchenko A, Xenarios I, Coudert E, Redaschi N, Bridge A; Nucleic Acids Res ; 2018; 10.1093/nar/gky876;

This record is maintained by amorgat

Record updated: May 19, 2020, 1:52 p.m. by amorgat.

Show edit history

Edits to 'https://fairsharing.org/FAIRsharing.pn1sr5' by 'amorgat' at 13:52, 19 May 2020 (approved):

	'countries' has been modified:
		Before:
			Austria
			Belgium
			Croatia
			Czech Republic
			Denmark
			Finland
			France
			Germany
			Greece
			Hungary
			Iceland
			Israel
			Italy
			Lithuania
			Luxembourg
			Malta
			Montenegro
			Netherlands
			Norway
			Portugal
			Republic of Ireland
			Slovakia
			Spain
			Sweden
			Switzerland
			United Kingdom
		After:
			Switzerland
			United Kingdom
		Added:
		Removed:
			Austria
			Belgium
			Croatia
			Czech Republic
			Denmark
			Finland
			France
			Germany
			Greece
			Hungary
			Iceland
			Israel
			Italy
			Lithuania
			Luxembourg
			Malta
			Montenegro
			Netherlands
			Norway
			Portugal
			Republic of Ireland
			Slovakia
			Spain
			Sweden

Edits to 'https://fairsharing.org/FAIRsharing.pn1sr5' by 'The FAIRsharing Team' at 20:05, 11 Feb 2020 (approved):

	'standardsImplemented' has been modified:
		Before:
			Chemical Entities of Biological Interest
			Chemical Markup Language
			MDL molfile Format
			MDL reaction Format
			RxNORM
			Structure Data Format
		After:
			Biological Pathway eXchange
			Chemical Entities of Biological Interest
			Chemical Markup Language
			MDL molfile Format
			MDL reaction Format
			RxNORM
			Resource Description Framework
			Structure Data Format
		Added:
			Biological Pathway eXchange
			Resource Description Framework
		Removed:

	'supportLinks' has been modified:
		Before:
			FAQ|https://www.rhea-db.org/faq
			contact form|http://www.rhea-db.org/feedback
			online documentation|http://www.rhea-db.org/documentation
			online documentation|https://www.rhea-db.org/statistics
			online documentation|https://www.rhea-db.org/changes
			rss|https://sourceforge.net/p/rhea-ebi/news/feed.rss
			twitter|@rhea_db
		After:
			FAQ|https://www.rhea-db.org/faq
			contact form|https://www.rhea-db.org/feedback
			online documentation|http://www.rhea-db.org/documentation
			online documentation|https://www.rhea-db.org/statistics
			online documentation|https://www.rhea-db.org/changes
			rss|https://sourceforge.net/p/rhea-ebi/news/feed.rss
			twitter|@rhea_db
		Added:
			contact form|https://www.rhea-db.org/feedback
		Removed:
			contact form|http://www.rhea-db.org/feedback

	'countries' has been modified:
		Before:
			European Union
			Switzerland
		After:
			Austria
			Belgium
			Croatia
			Czech Republic
			Denmark
			Finland
			France
			Germany
			Greece
			Hungary
			Iceland
			Israel
			Italy
			Lithuania
			Luxembourg
			Malta
			Montenegro
			Netherlands
			Norway
			Portugal
			Republic of Ireland
			Slovakia
			Spain
			Sweden
			Switzerland
			United Kingdom
		Added:
			Austria
			Belgium
			Croatia
			Czech Republic
			Denmark
			Finland
			France
			Germany
			Greece
			Hungary
			Iceland
			Israel
			Italy
			Lithuania
			Luxembourg
			Malta
			Montenegro
			Netherlands
			Norway
			Portugal
			Republic of Ireland
			Slovakia
			Spain
			Sweden
			United Kingdom
		Removed:
			European Union

	'dataProcesses' has been modified:
		Before:
			Download Data
			Expert curation
			Data Submission
			FTP download
			Advanced search
			Browse
		After:
			Download Data
			Expert curation
			Data Submission
			Advanced search
			Browse
		Added:
		Removed:
			FTP download

	'accessPoints' has been modified:
		Before:
			REST|https://www.rhea-db.org/webservice|Rhea Web Services
		After:
			REST|https://www.rhea-db.org/webservice|Rhea Web Services
			Other|https://sparql.rhea-db.org/sparql|SPARQL Endpoint
		Added:
			Other|https://sparql.rhea-db.org/sparql|SPARQL Endpoint
		Removed:

	'tools' has been modified:
		Before:
			ChemAxon||https://www.chemaxon.com/
			RxnSim|1.0.3|https://cran.r-project.org/web/packages/RxnSim/index.html
			Rhea SPARQL Endpoint||http://sparql.rhea-db.org/
		After:
			ChemAxon||https://www.chemaxon.com/
			RxnSim|1.0.3|https://cran.r-project.org/web/packages/RxnSim/index.html
		Added:
		Removed:
			Rhea SPARQL Endpoint||http://sparql.rhea-db.org/

Edits to 'https://fairsharing.org/FAIRsharing.pn1sr5' by 'amorgat' at 14:27, 13 Dec 2019 (approved):

	'tools' has been modified:
		Before:
			ChemAxon||https://www.chemaxon.com/
			RxnSim|1.0.3|https://cran.r-project.org/web/packages/RxnSim/index.html
			SPARQL Endpoint||http://sparql.rhea-db.org/
		After:
			ChemAxon||https://www.chemaxon.com/
			RxnSim|1.0.3|https://cran.r-project.org/web/packages/RxnSim/index.html
			Rhea SPARQL Endpoint||http://sparql.rhea-db.org/
		Added:
			Rhea SPARQL Endpoint||http://sparql.rhea-db.org/
		Removed:
			SPARQL Endpoint||http://sparql.rhea-db.org/

	'description' has been modified:
		Before: Rhea is a comprehensive and non-redundant resource of expert-curated chemical and transport reactions of biological interest. Rhea can be used for enzyme annotation, genome-scale metabolic modeling and omics-related analysis. Rhea describes enzyme-catalyzed reactions covering the IUBMB Enzyme Nomenclature list as well as additional reactions, including spontaneously occurring reactions. Rhea is built on ChEBI (Chemical Entities of Biological Interest) ontology of small molecules to describe its reaction participants.. 





		After: Rhea is a comprehensive and non-redundant resource of expert-curated chemical and transport reactions of biological interest. Rhea can be used for enzyme annotation, genome-scale metabolic modeling and omics-related analysis. Rhea describes enzyme-catalyzed reactions covering the IUBMB Enzyme Nomenclature list as well as additional reactions, including spontaneously occurring reactions. Rhea is built on ChEBI (Chemical Entities of Biological Interest) ontology of small molecules to describe its reaction participants. Since December 2018, Rhea is the standard for enzyme annotation in UniProt.






	'dataProcesses' has been modified:
		Before:
			FTP download
			Download Data
			manual curation
			Data Submission
			Advanced search
			Browse
		After:
			FTP download
			Download Data
			Expert curation
			Data Submission
			Advanced search
			Browse
		Added:
			Expert curation
		Removed:
			manual curation

	'publications' has been modified:
		Before:
			Updates in Rhea--a manually curated resource of biochemical reactions.|Morgat A, Axelsen KB, Lombardot T, Alcntara R, Aimo L, Zerara M, Niknejad A, Belda E, Hyka-Nouspikel N, Coudert E, Redaschi N, Bougueleret L, Steinbeck C, Xenarios I, Bridge A.|Nucleic Acids Res.|2014
			Rhea--a manually curated resource of biochemical reactions.|Alcantara R,Axelsen KB,Morgat A,Belda E,Coudert E,Bridge A,Cao H,de Matos P,Ennis M,Turner S,Owen G,Bougueleret L,Xenarios I,Steinbeck C|Nucleic Acids Res.|2011
			Updates in Rhea - an expert curated resource of biochemical reactions.|Morgat A, Lombardot T, Axelsen KB, Aimo L, Niknejad A, Hyka-Nouspikel N, Coudert E, Pozzato M, Pagni M, Moretti S, Rosanoff S, Onwubiko J, Bougueleret L, Xenarios I, Redaschi N, Bridge A.|Nucleic Acids Res.|2017
			Updates in Rhea: SPARQLing biochemical reaction data.|Lombardot T,Morgat A,Axelsen KB,Aimo L,Hyka-Nouspikel N,Niknejad A,Ignatchenko A,Xenarios I,Coudert E,Redaschi N,Bridge A|Nucleic Acids Res|2018
		After:
			Updates in Rhea--a manually curated resource of biochemical reactions.|Morgat A, Axelsen KB, Lombardot T, Alcntara R, Aimo L, Zerara M, Niknejad A, Belda E, Hyka-Nouspikel N, Coudert E, Redaschi N, Bougueleret L, Steinbeck C, Xenarios I, Bridge A.|Nucleic Acids Res.|2014
			Rhea--a manually curated resource of biochemical reactions.|Alcantara R,Axelsen KB,Morgat A,Belda E,Coudert E,Bridge A,Cao H,de Matos P,Ennis M,Turner S,Owen G,Bougueleret L,Xenarios I,Steinbeck C|Nucleic Acids Res.|2011
			Updates in Rhea - an expert curated resource of biochemical reactions.|Morgat A, Lombardot T, Axelsen KB, Aimo L, Niknejad A, Hyka-Nouspikel N, Coudert E, Pozzato M, Pagni M, Moretti S, Rosanoff S, Onwubiko J, Bougueleret L, Xenarios I, Redaschi N, Bridge A.|Nucleic Acids Res.|2017
			Updates in Rhea: SPARQLing biochemical reaction data.|Lombardot T, Morgat A, Axelsen KB, Aimo L, Hyka-Nouspikel N, Niknejad A, Ignatchenko A, Xenarios I, Coudert E, Redaschi N, Bridge A|Nucleic Acids Res|2018
			Enzyme annotation in UniProtKB using Rhea|Morgat A, Lombardot T, Coudert E, Axelsen K, Neto TB, Gehant S, Bansal P, Bolleman J, Gasteiger E, de Castro E, Baratin D, Pozzato M, Xenarios I, Poux S, Redaschi N, Bridge A and the UniProt Consortium|Bioinformatics|2019
		Added:
			Updates in Rhea: SPARQLing biochemical reaction data.|Lombardot T, Morgat A, Axelsen KB, Aimo L, Hyka-Nouspikel N, Niknejad A, Ignatchenko A, Xenarios I, Coudert E, Redaschi N, Bridge A|Nucleic Acids Res|2018
			Enzyme annotation in UniProtKB using Rhea|Morgat A, Lombardot T, Coudert E, Axelsen K, Neto TB, Gehant S, Bansal P, Bolleman J, Gasteiger E, de Castro E, Baratin D, Pozzato M, Xenarios I, Poux S, Redaschi N, Bridge A and the UniProt Consortium|Bioinformatics|2019
		Removed:
			Updates in Rhea: SPARQLing biochemical reaction data.|Lombardot T,Morgat A,Axelsen KB,Aimo L,Hyka-Nouspikel N,Niknejad A,Ignatchenko A,Xenarios I,Coudert E,Redaschi N,Bridge A|Nucleic Acids Res|2018

Edits to 'https://fairsharing.org/FAIRsharing.pn1sr5' by 'amorgat' at 13:39, 13 Dec 2019 (approved):

	'onto_domains' has been modified:
		Before:
			Annotation
			Biocuration
			Chemical formula
			Reaction data
			chemical entity
			curated information
			enzymatic reaction
			protein-containing complex
			small molecule
			transport
		After:
			Annotation
			Biocuration
			Chemical formula
			Reaction data
			chemical entity
			curated information
			enzymatic reaction
			small molecule
			transport
		Added:
		Removed:
			protein-containing complex

Edits to 'https://fairsharing.org/FAIRsharing.pn1sr5' by 'amorgat' at 15:48, 12 Dec 2019 (approved):

	'description' has been modified:
		Before: Rhea is a comprehensive and non-redundant resource of expert-curated biochemical reactions designed for the functional annotation of enzymes and the description of metabolic networks. Rhea describes enzyme-catalyzed reactions covering the IUBMB Enzyme Nomenclature list as well as additional reactions, including spontaneously occurring reactions, using entities from the ChEBI (Chemical Entities of Biological Interest) ontology of small molecules. 





		After: Rhea is a comprehensive and non-redundant resource of expert-curated chemical and transport reactions of biological interest. Rhea can be used for enzyme annotation, genome-scale metabolic modeling and omics-related analysis. Rhea describes enzyme-catalyzed reactions covering the IUBMB Enzyme Nomenclature list as well as additional reactions, including spontaneously occurring reactions. Rhea is built on ChEBI (Chemical Entities of Biological Interest) ontology of small molecules to describe its reaction participants.. 






	'onto_domains' has been modified:
		Before:
			Annotation
			Biocuration
			Chemical formula
			Reaction data
			chemical entity
			curated information
			enzymatic reaction
			small molecule
		After:
			Annotation
			Biocuration
			Chemical formula
			Reaction data
			chemical entity
			curated information
			enzymatic reaction
			protein-containing complex
			small molecule
			transport
		Added:
			protein-containing complex
			transport
		Removed:

	'contactORCID' has been modified:
		Before: 
		After: 0000-0002-1216-2969

Edits to 'https://fairsharing.org/FAIRsharing.pn1sr5' by 'The FAIRsharing Team' at 14:08, 08 Mar 2019 (approved):

	'supportLinks' has been modified:
		Before:
			contact form|http://www.rhea-db.org/feedback
			online documentation|http://www.rhea-db.org/documentation
			online documentation|https://www.rhea-db.org/statistics
		After:
			FAQ|https://www.rhea-db.org/faq
			contact form|http://www.rhea-db.org/feedback
			online documentation|http://www.rhea-db.org/documentation
			online documentation|https://www.rhea-db.org/statistics
			online documentation|https://www.rhea-db.org/changes
			rss|https://sourceforge.net/p/rhea-ebi/news/feed.rss
			twitter|@rhea_db
		Added:
			FAQ|https://www.rhea-db.org/faq
			online documentation|https://www.rhea-db.org/changes
			rss|https://sourceforge.net/p/rhea-ebi/news/feed.rss
			twitter|@rhea_db
		Removed:

	'onto_disciplines' has been modified:
		Before:
			Biochemistry
			Life Sciences
		After:
			Biochemistry
			Data Submission, Annotation and Curation
			Life Sciences
		Added:
			Data Submission, Annotation and Curation
		Removed:

	'tools' has been modified:
		Before:
			ChemAxon||https://www.chemaxon.com/
			Metabolic Tinker||http://osslab.lifesci.warwick.ac.uk/tinker.aspx
			RxnSim|1.0.1|https://cran.r-project.org/web/packages/RxnSim/index.html
			SPARQL Endpoint||http://sparql.rhea-db.org/
		After:
			ChemAxon||https://www.chemaxon.com/
			RxnSim|1.0.3|https://cran.r-project.org/web/packages/RxnSim/index.html
			SPARQL Endpoint||http://sparql.rhea-db.org/
		Added:
			RxnSim|1.0.3|https://cran.r-project.org/web/packages/RxnSim/index.html
		Removed:
			Metabolic Tinker||http://osslab.lifesci.warwick.ac.uk/tinker.aspx
			RxnSim|1.0.1|https://cran.r-project.org/web/packages/RxnSim/index.html

	'publications' has been modified:
		Before:
			Updates in Rhea--a manually curated resource of biochemical reactions.|Morgat A, Axelsen KB, Lombardot T, Alcntara R, Aimo L, Zerara M, Niknejad A, Belda E, Hyka-Nouspikel N, Coudert E, Redaschi N, Bougueleret L, Steinbeck C, Xenarios I, Bridge A.|Nucleic Acids Res.|2014
			Rhea--a manually curated resource of biochemical reactions.|Alcantara R,Axelsen KB,Morgat A,Belda E,Coudert E,Bridge A,Cao H,de Matos P,Ennis M,Turner S,Owen G,Bougueleret L,Xenarios I,Steinbeck C|Nucleic Acids Res.|2011
			Updates in Rhea - an expert curated resource of biochemical reactions.|Morgat A, Lombardot T, Axelsen KB, Aimo L, Niknejad A, Hyka-Nouspikel N, Coudert E, Pozzato M, Pagni M, Moretti S, Rosanoff S, Onwubiko J, Bougueleret L, Xenarios I, Redaschi N, Bridge A.|Nucleic Acids Res.|2017
		After:
			Updates in Rhea--a manually curated resource of biochemical reactions.|Morgat A, Axelsen KB, Lombardot T, Alcntara R, Aimo L, Zerara M, Niknejad A, Belda E, Hyka-Nouspikel N, Coudert E, Redaschi N, Bougueleret L, Steinbeck C, Xenarios I, Bridge A.|Nucleic Acids Res.|2014
			Rhea--a manually curated resource of biochemical reactions.|Alcantara R,Axelsen KB,Morgat A,Belda E,Coudert E,Bridge A,Cao H,de Matos P,Ennis M,Turner S,Owen G,Bougueleret L,Xenarios I,Steinbeck C|Nucleic Acids Res.|2011
			Updates in Rhea - an expert curated resource of biochemical reactions.|Morgat A, Lombardot T, Axelsen KB, Aimo L, Niknejad A, Hyka-Nouspikel N, Coudert E, Pozzato M, Pagni M, Moretti S, Rosanoff S, Onwubiko J, Bougueleret L, Xenarios I, Redaschi N, Bridge A.|Nucleic Acids Res.|2017
			Updates in Rhea: SPARQLing biochemical reaction data.|Lombardot T,Morgat A,Axelsen KB,Aimo L,Hyka-Nouspikel N,Niknejad A,Ignatchenko A,Xenarios I,Coudert E,Redaschi N,Bridge A|Nucleic Acids Res|2018
		Added:
			Updates in Rhea: SPARQLing biochemical reaction data.|Lombardot T,Morgat A,Axelsen KB,Aimo L,Hyka-Nouspikel N,Niknejad A,Ignatchenko A,Xenarios I,Coudert E,Redaschi N,Bridge A|Nucleic Acids Res|2018
		Removed:

	'onto_domains' has been modified:
		Before:
			Reaction data
			chemical entity
			curated information
			enzymatic reaction
			small molecule
		After:
			Annotation
			Biocuration
			Chemical formula
			Reaction data
			chemical entity
			curated information
			enzymatic reaction
			small molecule
		Added:
			Annotation
			Biocuration
			Chemical formula
		Removed:

Edits to 'https://fairsharing.org/FAIRsharing.pn1sr5' by 'The FAIRsharing Team' at 12:55, 17 Jan 2019 (approved):

	'organizations' has been modified:
		Before:
			Swiss Federal Government (SERI)|https://www.sbfi.admin.ch/sbfi/en/home.html|Funds
			SystemsX.ch|http://www.systemsx.ch/|Funds
			Swiss Institute of Bioinformatics (SIB), Switzerland|https://www.sib.swiss|Maintains
			European Commission under FP7 Grant Agreement|http://ec.europa.eu/research/fp7/index_en.cfm?pg=documents|Undefined
			European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridgeshire, UK|https://www.ebi.ac.uk/|Maintains
		After:
			Swiss Federal Government (SERI)|https://www.sbfi.admin.ch/sbfi/en/home.html|Funds
			SystemsX.ch|http://www.systemsx.ch/|Funds
			Swiss Institute of Bioinformatics (SIB), Switzerland|https://www.sib.swiss|Maintains
			European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridgeshire, UK|https://www.ebi.ac.uk/|Maintains
			European Commission under FP7 Grant Agreement|http://ec.europa.eu/research/fp7/index_en.cfm?pg=documents|Funds
		Added:
			European Commission under FP7 Grant Agreement|http://ec.europa.eu/research/fp7/index_en.cfm?pg=documents|Funds
		Removed:
			European Commission under FP7 Grant Agreement|http://ec.europa.eu/research/fp7/index_en.cfm?pg=documents|Undefined

Edits to 'https://fairsharing.org/FAIRsharing.pn1sr5' by 'The FAIRsharing Team' at 12:55, 17 Jan 2019 (approved):

	'organizations' has been modified:
		Before:
			European Commission under FP7 Grant Agreement|http://ec.europa.eu/research/fp7/index_en.cfm?pg=documents|Undefined
			Swiss Federal Government (SERI)|https://www.sbfi.admin.ch/sbfi/en/home.html|Funds
			Swiss Institute of Bioinformatics (SIB), Switzerland|https://www.sib.swiss|Maintains
			SystemsX.ch|http://www.systemsx.ch/|Funds
		After:
			Swiss Federal Government (SERI)|https://www.sbfi.admin.ch/sbfi/en/home.html|Funds
			SystemsX.ch|http://www.systemsx.ch/|Funds
			Swiss Institute of Bioinformatics (SIB), Switzerland|https://www.sib.swiss|Maintains
			European Commission under FP7 Grant Agreement|http://ec.europa.eu/research/fp7/index_en.cfm?pg=documents|Undefined
			European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridgeshire, UK|https://www.ebi.ac.uk/|Maintains
		Added:
			European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridgeshire, UK|https://www.ebi.ac.uk/|Maintains
		Removed:

	'related_databases' has been modified:
		Before:
			Mechanism, Annotation and Classification in Enzymes
			MetaCyc
			MetaboLights
			Reactome - a curated knowledgebase of biological pathways
			UniPathway
			UniProt Knowledgebase
			Kyoto Encyclopedia of Genes and Genomes
			SwissLipids
			MetaNetX
		After:
			Mechanism, Annotation and Classification in Enzymes
			MetaCyc
			MetaboLights
			Integrated relational Enzyme database
			Reactome - a curated knowledgebase of biological pathways
			UniPathway
			UniProt Knowledgebase
			Kyoto Encyclopedia of Genes and Genomes
			SwissLipids
			MetaNetX
			Enzyme nomenclature database
		Added:
			Integrated relational Enzyme database
			Enzyme nomenclature database
		Removed:

	'supportLinks' has been modified:
		Before:
			contact form|http://www.rhea-db.org/feedback
			online documentation|http://www.rhea-db.org/documentation
		After:
			contact form|http://www.rhea-db.org/feedback
			online documentation|http://www.rhea-db.org/documentation
			online documentation|https://www.rhea-db.org/statistics
		Added:
			online documentation|https://www.rhea-db.org/statistics
		Removed:

	'dataProcesses' has been modified:
		Before:
			FTP download
			monthly release
			manual curation
			user request
			advanced search
			submit
			browse
		After:
			FTP download
			Download Data
			manual curation
			Data Submission
			Advanced search
			Browse
		Added:
			Download Data
			Data Submission
			Advanced search
			Browse
		Removed:
			monthly release
			user request
			advanced search
			submit
			browse

	'accessPoints' has been modified:
		Before:
			REST|http://www.rhea-db.org/rest/1.0/ws/reaction?q=caffeine|Rhea webservice
		After:
			REST|https://www.rhea-db.org/webservice|Rhea Web Services
		Added:
			REST|https://www.rhea-db.org/webservice|Rhea Web Services
		Removed:
			REST|http://www.rhea-db.org/rest/1.0/ws/reaction?q=caffeine|Rhea webservice

	'tools' has been modified:
		Before:
			ChemAxon||https://www.chemaxon.com/
			Metabolic Tinker||http://osslab.lifesci.warwick.ac.uk/tinker.aspx
			RxnSim|1.0.1|https://cran.r-project.org/web/packages/RxnSim/index.html
		After:
			ChemAxon||https://www.chemaxon.com/
			Metabolic Tinker||http://osslab.lifesci.warwick.ac.uk/tinker.aspx
			RxnSim|1.0.1|https://cran.r-project.org/web/packages/RxnSim/index.html
			SPARQL Endpoint||http://sparql.rhea-db.org/
		Added:
			SPARQL Endpoint||http://sparql.rhea-db.org/
		Removed:

Edits to 'https://fairsharing.org/FAIRsharing.pn1sr5' by 'amorgat' at 08:46, 02 Dec 2016 (approved):

	'description' has been modified:
		Before: Rhea is a comprehensive and non-redundant resource of biochemical reactions described using species from the ChEBI (Chemical Entities of Biological Interest) ontology of small molecules. Rhea has been designed for the functional annotation of enzymes and the description, analysis and reconciliation of genome-scale metabolic networks.
		After: Rhea is a comprehensive and non-redundant resource of expert-curated biochemical reactions designed for the functional annotation of enzymes and the description of metabolic networks. Rhea describes enzyme-catalyzed reactions covering the IUBMB Enzyme Nomenclature list as well as additional reactions, including spontaneously occurring reactions, using entities from the ChEBI (Chemical Entities of Biological Interest) ontology of small molecules.  Publication List has changed:  Previous values: Updates in Rhea--a manually curated resource of biochemical reactions. Rhea--a manually curated resource of biochemical reactions. Updates in rhea-an expert curated resource of biochemical reactions. New values:  Updates in Rhea--a manually curated resource of biochemical reactions. Rhea--a manually curated resource of biochemical reactions. Added Rhea to policy F1000Research Data Policy.

Edits to 'https://fairsharing.org/FAIRsharing.pn1sr5' by 'amorgat' at 12:29, 30 Nov 2016 (approved):

	'contactEmail' has been modified:
		Before: anne.morgat@isb-sib.ch
		After: anne.morgat@sib.swiss Domain list has changed:  Previous values: Biochemistry|process|http://ontology.neuinfo.org/NIF/DigitalEntities/NIF-Scientific-Discipline.owl#nlx_inv_100610 Chemical entity|material|http://purl.obolibrary.org/obo/CHEBI_24431 Enzymatic reaction|process|http://purl.obolibrary.org/obo/MI_0414 Life Science|domain| Manual curation|x| Reaction|| Small molecule|material| New values:  Biochemistry|process|http://ontology.neuinfo.org/NIF/DigitalEntities/NIF-Scientific-Discipline.owl#nlx_inv_100610 Enzymatic reaction|process|http://purl.obolibrary.org/obo/MI_0414 Reaction|| Chemical entity|material|http://purl.obolibrary.org/obo/CHEBI_24431 Small molecule|material| Life Science|domain| Manual curation|x| Countries have changed:  Previous values: European Union Switzerland New values:  Switzerland European Union Publication List has changed:  Previous values: Updates in Rhea--a manually curated resource of biochemical reactions. Rhea--a manually curated resource of biochemical reactions. New values:  Updates in Rhea--a manually curated resource of biochemical reactions. Rhea--a manually curated resource of biochemical reactions. Updates in rhea-an expert curated resource of biochemical reactions. Organisations have changed:  Previous values: European Bioinformatics Institute (EMBL-EBI)|Wellcome Trust Genome Campus|Hinxton|Cambridge|UK European Commission FP7 SIB|Swiss Institute of Bioinformatics Swiss Federal Government (SERI) SystemsX.ch New values:  SIB|Swiss Institute of Bioinformatics European Bioinformatics Institute (EMBL-EBI)|Wellcome Trust Genome Campus|Hinxton|Cambridge|UK Swiss Federal Government (SERI) SystemsX.ch Grants have changed:  Previous values: 222886-2 New values:  Added Rhea to policy F1000Research Data Policy.

Edits to 'https://fairsharing.org/FAIRsharing.pn1sr5' by 'The FAIRsharing Team' at 14:14, 08 Sep 2016 (approved):

	'name' has been modified:
		Before: Rhea: an expert curated resource of biochemical reactions
		After: Rhea

Edits to 'https://fairsharing.org/FAIRsharing.pn1sr5' by 'The FAIRsharing Team' at 17:39, 02 Sep 2016 (approved):

	'contactName' has been modified:
		Before:
			Anne MORGAT
		After:
			Anne Morgat
			Data processes have changed: 
			Previous values:
			FTP download
			monthly release
			manual curation
			user request
			web interface
			web service
			New values: 
			FTP download
			monthly release
			manual curation
			user request
			advanced search
			submit
			browse
		Added:
		Removed:

In Collections

Data Citation Implementation

EOSC-Life

Chemistry

Support

General

FAQ	FAQ
contact form	Feedback Form
online documentation	Documentation
online documentation	Statistics
online documentation	Changes
rss	News
twitter	@rhea_db

Additional Information

Contact

Anne Morgat ORCID

Tools

ChemAxon	https://www.chemaxon.com/
RxnSim	https://cran.r-project.org/web/packages/RxnSim/index.html	1.0.3

Access / Retrieve Data

Conditions of Use

Applies to: Data use

Creative Commons Attribution 4.0 International (CC BY 4.0)

Data Release

Download Data

https://www.rhea-db.org/download

Data Curation

Expert curation	No link recorded
Data Submission	https://www.rhea-db.org/submit

Data Access

Advanced search	https://www.rhea-db.org/advancedsearch
Browse	https://www.rhea-db.org/searchresults?q=chebi*

REST Web Services

Rhea Web Services

https://www.rhea-db.org/webservice

Other Web Services

SPARQL Endpoint

https://sparql.rhea-db.org/sparql

Publications

Updates in Rhea--a manually curated resource of biochemical reactions.

Morgat A, Axelsen KB, Lombardot T, Alcántara R, Aimo L, Zerara M, Niknejad A, Belda E, Hyka-Nouspikel N, Coudert E, Redaschi N, Bougueleret L, Steinbeck C, Xenarios I, Bridge A.
Nucleic Acids Res. 2014