databases > DOI:10.25504/FAIRsharing.xgcyyn
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ready CATH

General Information
The CATH database is a free, publicly available online resource that provides information on the evolutionary relationships of protein domains. It provides a hierarchical domain classification of protein structures in the Protein Data Bank. Protein structures are classified using a combination of automated and manual procedures. There are four major levels in this hierarchy; Class (secondary structure classification, e.g. mostly alpha), Architecture (classification based on overall shape), Topology (fold family) and Homologous superfamily (protein domains which are thought to share a common ancestor).




How to cite this record FAIRsharing.org: CATH; CATH; DOI: https://doi.org/10.25504/FAIRsharing.xgcyyn; Last edited: March 7, 2021, 8:33 p.m.; Last accessed: Sep 28 2021 7:31 a.m.

Publication for citation  CATH: increased structural coverage of functional space. Sillitoe I,Bordin N,Dawson N,Waman VP,Ashford P,Scholes HM,Pang CSM,Woodridge L,Rauer C,Sen N,Abbasian M,Le Cornu S,Lam SD,Berka K,Varekova IH,Svobodova R,Lees J,Orengo CA; Nucleic Acids Res ; 2020; 10.1093/nar/gkaa1079 ;


This record is maintained by isillitoe  ORCID

Record updated: March 7, 2021, 8:31 p.m. by The FAIRsharing Team.

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CATH--a hierarchic classification of protein domain structures.

Orengo CA., Michie AD., Jones S., Jones DT., Swindells MB., Thornton JM.,
Structure 1997

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Functional classification of CATH superfamilies: a domain-based approach for protein function annotation.

Das S,Lee D,Sillitoe I,Dawson NL,Lees JG,Orengo CA
Bioinformatics 2016

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The history of the CATH structural classification of protein domains.

Sillitoe I,Dawson N,Thornton J,Orengo C
Biochimie 2015

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CATH: comprehensive structural and functional annotations for genome sequences.

Sillitoe I,Lewis TE,Cuff A,Das S,Ashford P,Dawson NL,Furnham N,Laskowski RA,Lee D,Lees JG,Lehtinen S,Studer RA,Thornton J,Orengo CA
Nucleic Acids Res 2014

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The CATH protein family database: a resource for structural and functional annotation of genomes.

Orengo CA,Bray JE,Buchan DW,Harrison A,Lee D,Pearl FM,Sillitoe I,Todd AE,Thornton JM
Proteomics 2002

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CATH: an expanded resource to predict protein function through structure and sequence.

Dawson NL,Lewis TE,Das S,Lees JG,Lee D,Ashford P,Orengo CA,Sillitoe I
Nucleic Acids Res 2016

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Gene3D: Extensive prediction of globular domains in proteins.

Lewis TE,Sillitoe I,Dawson N,Lam SD,Clarke T,Lee D,Orengo C,Lees J
Nucleic Acids Res 2017

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CATH: expanding the horizons of structure-based functional annotations for genome sequences.

Sillitoe I,Dawson N,Lewis TE,Das S,Lees JG,Ashford P,Tolulope A,Scholes HM,Senatorov I,Bujan A,Ceballos Rodriguez-Conde F,Dowling B,Thornton J,Orengo CA
Nucleic Acids Res 2018

View Paper (PubMed) View Publication

CATH: increased structural coverage of functional space.

Sillitoe I,Bordin N,Dawson N,Waman VP,Ashford P,Scholes HM,Pang CSM,Woodridge L,Rauer C,Sen N,Abbasian M,Le Cornu S,Lam SD,Berka K,Varekova IH,Svobodova R,Lees J,Orengo CA
Nucleic Acids Res 2020

View Paper (PubMed) View Publication

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  • 081989/Z/07/Z (The Wellcome Trust, UK)

  • BB/K020013/1 (Biotechnology and Biological Sciences Research Council (BBSRC), UK)