Record added: April 12, 2016, 2:15 p.m.
Record updated: July 23, 2020, 3:34 p.m. by panelapp.

Edits to 'https://fairsharing.org/FAIRsharing.yfk4w2' by 'panelapp' at 15:34, 23 Jul 2020 (approved):

	'description' has been modified:
		Before: Genomics England PanelApp is a publically-available knowledgebase that allows virtual gene panels related to human disorders to be created, stored and queried. It includes a crowdsourcing tool that allows genes to be added or reviewed by experts throughout the worldwide scientific community, providing an opportunity for the standardisation of gene panels, and a consensus on which genes have sufficient evidence for disease association.

The diagnostic grade ?Green? genes and their modes of inheritance in the Version 1+ PanelApp virtual gene panels are used to direct the variant tiering process for the interpretation of genomes in the 100,000 Genomes Project. As panels in PanelApp are publically available, they can also be utilised by others. Experts are asked to register (https://panelapp.genomicsengland.co.uk/accounts/registration/) in order to review and rate the genes on the panel to indicate whether there is a diagnostic-grade level of evidence for the gene to be implicated in a given disease. Bioinformaticians can access the data via the PanelApp API (https://panelapp.genomicsengland.co.uk/#!API). More detailed background information, instructions and updates can be found on the PanelApp homepage tabs.
		After: Genomics England PanelApp is a publically-available knowledgebase that allows virtual gene panels related to human disorders to be created, stored and queried. It includes a crowdsourcing tool that allows genes to be added or reviewed by experts throughout the worldwide scientific community, providing an opportunity for the standardisation of gene panels, and a consensus on which genes have sufficient evidence for disease association.

The diagnostic grade ?Green? genes and their modes of inheritance in the Version 1+ PanelApp virtual gene panels are used to direct the variant tiering process for the interpretation of genomes in the 100,000 Genomes Project and for the National Health Service England Genomic Medicine Service. As panels in PanelApp are publically available, they can also be utilised by others. Experts are asked to register (https://panelapp.genomicsengland.co.uk/accounts/registration/) in order to review and rate the genes on the panel to indicate whether there is a diagnostic-grade level of evidence for the gene to be implicated in a given disease. Bioinformaticians can access the data via the PanelApp API (https://panelapp.genomicsengland.co.uk/#!API). More detailed background information, instructions and updates can be found on the PanelApp homepage tabs.

            

Edits to 'https://fairsharing.org/FAIRsharing.yfk4w2' by 'The FAIRsharing Team' at 20:29, 20 Jul 2020 (approved):

	'user_defined_tags' has been modified:
		Before:
		After:
			COVID-19
		Added:
			COVID-19
		Removed:

	'publications' has been modified:
		Before:
		After:
			PanelApp crowdsources expert knowledge to establish consensus diagnostic gene panels.|Martin AR,Williams E,Foulger RE,Leigh S,Daugherty LC,Niblock O,Leong IUS,Smith KR,Gerasimenko O,Haraldsdottir E,Thomas E,Scott RH,Baple E,Tucci A,Brittain H,de Burca A,Ibanez K,Kasperaviciute D,Smedley D,Caulfield M,Rendon A,McDonagh EM|Nat Genet|2019
		Added:
			PanelApp crowdsources expert knowledge to establish consensus diagnostic gene panels.|Martin AR,Williams E,Foulger RE,Leigh S,Daugherty LC,Niblock O,Leong IUS,Smith KR,Gerasimenko O,Haraldsdottir E,Thomas E,Scott RH,Baple E,Tucci A,Brittain H,de Burca A,Ibanez K,Kasperaviciute D,Smedley D,Caulfield M,Rendon A,McDonagh EM|Nat Genet|2019
		Removed:

            

Edits to 'https://fairsharing.org/FAIRsharing.yfk4w2' by 'panelapp' at 12:12, 27 Apr 2020 (approved):

	'contact' has been modified:
		Before: Ellen McDonagh
		After: PanelApp team

	'description' has been modified:
		Before: Genomics England PanelApp is a publically-available knowledgebase that allows virtual gene panels related to human disorders to be created, stored and queried. It includes a crowdsourcing tool that allows genes to be added or reviewed by experts throughout the worldwide scientific community, providing an opportunity for the standardisation of gene panels, and a consensus on which genes have sufficient evidence for disease association.

The diagnostic grade ?Green? genes and their modes of inheritance in the Version 1+ PanelApp virtual gene panels are used to direct the variant tiering process for the interpretation of genomes in the 100,000 Genomes Project. As panels in PanelApp are publically available, they can also be utilised by others. Experts are asked to register (https://panelapp.genomicsengland.co.uk/accounts/registration/) in order to review and rate the genes on the panel to indicate whether there is a diagnostic-grade level of evidence for the gene to be implicated in a given disease. Bioinformaticians can access the data via the PanelApp webservices (https://panelapp.genomicsengland.co.uk/#!Webservices). More detailed background information, instructions and updates can be found on the PanelApp homepage tabs.
		After: Genomics England PanelApp is a publically-available knowledgebase that allows virtual gene panels related to human disorders to be created, stored and queried. It includes a crowdsourcing tool that allows genes to be added or reviewed by experts throughout the worldwide scientific community, providing an opportunity for the standardisation of gene panels, and a consensus on which genes have sufficient evidence for disease association.

The diagnostic grade ?Green? genes and their modes of inheritance in the Version 1+ PanelApp virtual gene panels are used to direct the variant tiering process for the interpretation of genomes in the 100,000 Genomes Project. As panels in PanelApp are publically available, they can also be utilised by others. Experts are asked to register (https://panelapp.genomicsengland.co.uk/accounts/registration/) in order to review and rate the genes on the panel to indicate whether there is a diagnostic-grade level of evidence for the gene to be implicated in a given disease. Bioinformaticians can access the data via the PanelApp API (https://panelapp.genomicsengland.co.uk/#!API). More detailed background information, instructions and updates can be found on the PanelApp homepage tabs.

	'contactORCID' has been modified:
		Before: 0000-0001-5806-6174
		After: 

            

Edits to 'https://fairsharing.org/FAIRsharing.yfk4w2' by 'The FAIRsharing Team' at 09:07, 22 Apr 2020 (approved):

	'supportLinks' has been modified:
		Before:
			help|https://panelapp.genomicsengland.co.uk/
			twitter|@GenomicsEngland
		After:
			FAQ|https://panelapp.genomicsengland.co.uk/#!FAQs
			blog|https://panelapp.genomicsengland.co.uk/#!News
			help|https://panelapp.genomicsengland.co.uk/
			help|https://panelapp.genomicsengland.co.uk/#!Navigating
			online documentation|https://panelapp.genomicsengland.co.uk/#!Guidelines
			twitter|@GenomicsEngland
		Added:
			FAQ|https://panelapp.genomicsengland.co.uk/#!FAQs
			blog|https://panelapp.genomicsengland.co.uk/#!News
			help|https://panelapp.genomicsengland.co.uk/#!Navigating
			online documentation|https://panelapp.genomicsengland.co.uk/#!Guidelines
		Removed:

	'contactORCID' has been modified:
		Before: 
		After: 0000-0001-5806-6174

	'licences' has been modified:
		Before:
		After:
			PanelApp Terms of Use|https://panelapp.genomicsengland.co.uk/media/files/GEL_-_PanelApp_Terms_of_Use_December_2019.pdf|Data
		Added:
			PanelApp Terms of Use|https://panelapp.genomicsengland.co.uk/media/files/GEL_-_PanelApp_Terms_of_Use_December_2019.pdf|Data
		Removed:

	'onto_disciplines' has been modified:
		Before:
			Genomics
		After:
			Epidemiology
			Genomics
			Life Science
			Virology
		Added:
			Epidemiology
			Life Science
			Virology
		Removed:

	'dataProcesses' has been modified:
		Before:
		After:
			Browse & search genes and genomic entities
			Browse panels
		Added:
			Browse & search genes and genomic entities
			Browse panels
		Removed:

	'accessPoints' has been modified:
		Before:
		After:
			Other|https://panelapp.genomicsengland.co.uk/#!API|PanelApp API
		Added:
			Other|https://panelapp.genomicsengland.co.uk/#!API|PanelApp API
		Removed:

            

Edits to 'https://fairsharing.org/FAIRsharing.yfk4w2' by 'emcdonagh' at 15:28, 14 Feb 2018 (approved):

	'supportLinks' has been modified:
		Before:
			https://bioinfo.extge.co.uk/crowdsourcing/PanelApp/
			@GenomicsEngland
			@PanelApp
		After:
			https://panelapp.genomicsengland.co.uk/
			@GenomicsEngland
		Added:
			https://panelapp.genomicsengland.co.uk/
		Removed:
			https://bioinfo.extge.co.uk/crowdsourcing/PanelApp/
			@PanelApp

            

Edits to 'https://fairsharing.org/FAIRsharing.yfk4w2' by 'emcdonagh' at 15:25, 14 Feb 2018 (approved):

	'description' has been modified:
		Before: The 100,000 Genomes Project database is publicly available via the PanelApp tool/app and gene panels can be viewed and downloaded from the website, or queried using the PanelApp web services. PanelApp is a crowdsourcing tool to allow gene panels to be shared, downloaded, viewed and evaluated by the Scientific Community. Gene panels were initially established for all the rare diseases in the 100,000 Genomes Project. The full list of available panels is available here: https://bioinfo.extge.co.uk/crowdsourcing/PanelApp/PanelBrowser.  Experts are asked to register in order to review and rate the genes on the panel to indicate whether there is a diagnostic-grade level of evidence for the gene to be implicated in a given disease. Guidelines for the level of evidence are provided on the Gene Panel Guidelines and Principles tab on the homepage. More detailed background information, instructions and updates can be found on the PanelApp homepage tabs. 
		After: Genomics England PanelApp is a publically-available knowledgebase that allows virtual gene panels related to human disorders to be created, stored and queried. It includes a crowdsourcing tool that allows genes to be added or reviewed by experts throughout the worldwide scientific community, providing an opportunity for the standardisation of gene panels, and a consensus on which genes have sufficient evidence for disease association. The diagnostic grade Green genes and their modes of inheritance in the Version 1+ PanelApp virtual gene panels are used to direct the variant tiering process for the interpretation of genomes in the 100,000 Genomes Project. As panels in PanelApp are publically available|they can also be utilised by others. Experts are asked to register (https://panelapp.genomicsengland.co.uk/accounts/registration/) in order to review and rate the genes on the panel to indicate whether there is a diagnostic-grade level of evidence for the gene to be implicated in a given disease. Bioinformaticians can access the data via the PanelApp webservices (https://panelapp.genomicsengland.co.uk/#!Webservices). More detailed background information|instructions and updates can be found on the PanelApp homepage tabs.