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deprecated Mechanism, Annotation and Classification in Enzymes


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This record was deprecated on April 10, 2018 for the following reason(s): This resource is now obsolete and, together with CSA (, has formed the basis of the M-CSA resource.

MACiE is an electronic database of well-characterised enzymatic reactions. MACiE is the result of more than three years' collaboration between the Mitchell and Murray-Rust groups in the Unilever Centre and Prof. Janet Thornton at the European Bioinformatics Institute. The database contains the reaction mechanisms for 100 individual enzymes; this includes the overall reactions and the multiple steps that constitute them.

How to cite this record MACiE; Mechanism, Annotation and Classification in Enzymes; DOI:; Last edited: Feb. 11, 2020, 8:57 p.m.; Last accessed: Jan 17 2022 5:10 a.m.

This record is maintained by AntonioRibeiro

Record updated: Feb. 11, 2020, 8:56 p.m. by The FAIRsharing Team.

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MACiE: a database of enzyme reaction mechanisms.

Holliday GL., Bartlett GJ., Almonacid DE., O'Boyle NM., Murray-Rust P., Thornton JM., Mitchell JB.,
Bioinformatics 2005

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MACiE (Mechanism, Annotation and Classification in Enzymes): novel tools for searching catalytic mechanisms.

Holliday GL., Almonacid DE., Bartlett GJ., O'Boyle NM., Torrance JW., Murray-Rust P., Mitchell JB., Thornton JM.,
Nucleic Acids Res. 2007

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  • BB/C51320X/1 (Biotechnology and Biological Sciences Research Council (BBSRC), UK)