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ready Simple Modular Architecture Research Tool


General Information
SMART (Simple Modular Architecture Research Tool) is a web resource providing simple identification and extensive annotation of protein domains and the exploration of protein domain architectures. It allows the identification and annotation of genetically mobile domains and the analysis of domain architectures. More than 500 domain families found in signalling, extracellular and chromatin-associated proteins are detectable. These domains are extensively annotated with respect to phyletic distributions, functional class, tertiary structures and functionally important residues. Each domain found in a non-redundant protein database as well as search parameters and taxonomic information are stored in a relational database system. User interfaces to this database allow searches for proteins containing specific combinations of domains in defined taxa.


Countries that developed this resource Germany

Created in 1998

Taxonomic range


How to cite this record SMART; Simple Modular Architecture Research Tool; DOI:; Last edited: Jan. 8, 2019, 1:14 p.m.; Last accessed: Nov 28 2021 3:34 a.m.

Record updated: Aug. 13, 2018, 5:08 p.m. by The FAIRsharing Team.

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SMART 6: recent updates and new developments.

Letunic I,Doerks T,Bork P
Nucleic Acids Res 2008

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SMART 5: domains in the context of genomes and networks.

Letunic I,Copley RR,Pils B,Pinkert S,Schultz J,Bork P
Nucleic Acids Res 2005

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SMART 4.0: towards genomic data integration.

Letunic I,Copley RR,Schmidt S,Ciccarelli FD,Doerks T,Schultz J,Ponting CP,Bork P
Nucleic Acids Res 2003

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SMART: a web-based tool for the study of genetically mobile domains.

Schultz J,Copley RR,Doerks T,Ponting CP,Bork P
Nucleic Acids Res 1999

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Protein families in multicellular organisms.

Copley RR,Schultz J,Ponting CP,Bork P
Curr Opin Struct Biol 1999

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SMART: identification and annotation of domains from signalling and extracellular protein sequences.

Ponting CP,Schultz J,Milpetz F,Bork P
Nucleic Acids Res 1998

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20 years of the SMART protein domain annotation resource.

Letunic I,Bork P
Nucleic Acids Res 2017

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SMART: recent updates, new developments and status in 2015.

Letunic I,Doerks T,Bork P
Nucleic Acids Res 2014

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SMART 7: recent updates to the protein domain annotation resource.

Letunic I,Doerks T,Bork P
Nucleic Acids Res 2011

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Recent improvements to the SMART domain-based sequence annotation resource.

Letunic I,Goodstadt L,Dickens NJ,Doerks T,Schultz J,Mott R,Ciccarelli F,Copley RR,Ponting CP,Bork P
Nucleic Acids Res 2001

View Paper (PubMed)

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Grant Number(s)

  • 213037 (European FP7 capacities: Scientific Data Repositories)