Databases > DOI:10.25504/FAIRsharing.aqb4ne

ready CUBE-DB

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Detection of functional divergence in human protein families. Cube-DB is a database of pre-evaluated conservation and specialization scores for residues in paralogous proteins belonging to multi-member families of human proteins. Protein family classification follows (largely) the classification suggested by HUGO Gene Nomenclature Committee. Sets of orthologous protein sequences were generated by mutual-best-hit strategy using full vertebrate genomes available in Ensembl. The scores, described on documentation page, are assigned to each individual residue in a protein, and presented in the form of a table (html or downloadable xls formats) and mapped, when appropriate, onto the related structure (Jmol, Pymol, Chimera).




How to cite this record FAIRsharing.org: CUBE-DB; CUBE-DB; DOI: https://doi.org/10.25504/FAIRsharing.aqb4ne; Last edited: Feb. 22, 2018, 2:44 p.m.; Last accessed: Jul 22 2018 4:14 a.m.


Record updated: Sept. 26, 2016, 10:26 a.m. by The FAIRsharing Team.

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Determinants, discriminants, conserved residues--a heuristic approach to detection of functional divergence in protein families.

Bharatham K., Zhang ZH., Mihalek I.,
PLoS ONE 2011

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Cube-DB: detection of functional divergence in human protein families.

Zhang ZH,Bharatham K,Chee SM,Mihalek I
Nucleic Acids Res 2011

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