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ready TDR Targets

General Information
Identification and ranking of targets and bioactive compounds against neglected tropical diseases. TDR Targets integrates chemical and genomic information and allows users to prioritize targets and compounds to develop and repurpose new drugs and chemical tools for human pathogens. The TDR Target Project was started in 2005 after a call for applications was launched by TDR (Special Programme for Research and Training in Tropical Diseases (UNICEF / UNDP / World Bank / WHO, http://www.who.int/tdr)). As a result, the TDR Targets Database was established to help develop a portfolio of candidate drug targets for 5 major human pathogens. This shortly turned into a resource for prioritizing targets for neglected tropical diseases. TDR Targets is led and run by the Trypanosomatics group at IIB-UNSAM (Argentina, https://trypanosomatics.org) with help with external collaborators worldwide.

Homepage https://tdrtargets.org

Countries that developed this resource Argentina

Created in 2007

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How to cite this record FAIRsharing.org: TDR Targets; TDR Targets; DOI: https://doi.org/10.25504/FAIRsharing.6c4fvf; Last edited: Oct. 22, 2019, 11:07 a.m.; Last accessed: Sep 22 2020 9:13 a.m.


This record is maintained by fernan  ORCID

Record updated: Oct. 21, 2019, 3:34 p.m. by fernan.

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Chemistry
RDA Covid-19 WG Resources


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Data Versioning

versioning of by revision control system [web application code (atomic changes)] No link recorded
access to historical database dumps (SQL dumps) possible No link recorded

Data Release

6-9 months No link recorded

Data Curation

manual curation No link recorded
submit http://tdrtargets.org/survey

Data Access

file download(CSV,txt,tab-delimited) No link recorded
register http://tdrtargets.org/user/register
browse http://tdrtargets.org/survey
search http://tdrtargets.org/survey



Publications

Genomic-scale prioritization of drug targets: the TDR Targets database.

Agüero F., Al-Lazikani B., Aslett M., Berriman M., Buckner FS., Campbell RK., Carmona S., Carruthers IM., Chan AW., Chen F., Crowther GJ., Doyle MA., Hertz-Fowler C., Hopkins AL., McAllister G., Nwaka S., Overington JP., Pain A., Paolini GV., Pieper U., Ralph SA., Riechers A., Roos DS., Sali A., Shanmugam D., Suzuki T., Van Voorhis WC., Verlinde CL.,
Nat Rev Drug Discov 2008

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Identification of attractive drug targets in neglected-disease pathogens using an in silico approach.

Crowther GJ., Shanmugam D., Carmona SJ., Doyle MA., Hertz-Fowler C., Berriman M., Nwaka S., Ralph SA., Roos DS., Van Voorhis WC., Agüero F.,
PLoS Negl Trop Dis 2010

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TDR Targets: a chemogenomics resource for neglected diseases.

Magarinos MP,Carmona SJ,Crowther GJ,Ralph SA,Roos DS,Shanmugam D,Van Voorhis WC,Aguero F
Nucleic Acids Res 2011

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Grant Number(s)

  • A50830| (World Health Organization, Special Programme for Research and Training in Tropical Diseases (WHO/TDR))

  • PICT-2010-1479 (Agencia Nacional de Promoci?n Cient?fica (ANPCyT, Argentina))

  • PICT-Glaxo-2013-0067 (Agencia Nacional de Promoci?n Cient?fica (ANPCyT, Argentina))