ready Clusters of Orthologous Groups of Proteins: Phylogenetic classification of proteins encoded in complete genomes


General Information
Clusters of Orthologous Groups of proteins (COGs) were delineated by comparing protein sequences encoded in complete genomes, representing major phylogenetic lineages. Each COG consists of individual proteins or groups of paralogs from at least 3 lineages and thus corresponds to an ancient conserved domain.


Developed in USA

Created in 1996

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Record updated: Sept. 16, 2016, 1:54 p.m. by The FAIRsharing Team.


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A genomic perspective on protein families.

Tatusov RL., Koonin EV., Lipman DJ.,
Science 1997

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Expanded microbial genome coverage and improved protein family annotation in the COG database.

Galperin MY,Makarova KS,Wolf YI,Koonin EV
Nucleic Acids Res 2014

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