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Biological General Repository for Interaction Datasets

Abbreviation:BioGRID

Recommended

General Information

The Biological General Repository for Interaction Datasets (BioGRID) is a public database that archives and disseminates genetic and protein interaction data from model organisms and humans. BioGRID currently holds over 1,740,000 interactions curated from both high-throughput datasets and individual focused studies, as derived from over 70,000+ publications in the primary literature. Complete coverage of the entire literature is maintained for budding yeast (S. cerevisiae), fission yeast (S. pombe) and thale cress (A. thaliana), and efforts to expand curation across multiple metazoan species are underway. All data are freely provided via our search index and available for download in many standardized formats.

Homepage http://www.thebiogrid.org

Countries that developed this resource Canada , United States

Created in 2002

Taxonomic range

Arabidopsis thaliana

Bos taurus

Caenorhabditis elegans

Candida albicans

Drosophila melanogaster

Human immunodeficiency virus

Mus musculus

Plasmodium falciparum

Rattus norvegicus

SARS-CoV-2

Saccharomyces cerevisiae

Schizosaccharomyces pombe

Xenopus laevis

Knowledge Domains

Subjects

User-defined Tags

Physical interaction

In the following recommendations:

How to cite this record FAIRsharing.org: BioGRID; Biological General Repository for Interaction Datasets; DOI: https://doi.org/10.25504/FAIRsharing.9d5f5r; Last edited: March 9, 2021, 4:07 p.m.; Last accessed: Nov 27 2021 10:53 p.m.

Publication for citation BioGRID: a general repository for interaction datasets. Stark C., Breitkreutz BJ., Reguly T., Boucher L., Breitkreutz A., Tyers M., ; Nucleic Acids Res. ; 2006.

This record is maintained by AndrewWillems ORCID

Record updated: March 3, 2021, 8:31 a.m. by The FAIRsharing Team.

Show edit history

Edits to 'https://fairsharing.org/FAIRsharing.9d5f5r' by 'The FAIRsharing Team' at 08:31, 03 Mar 2021 (approved):

	'supportLinks' has been modified:
		Before:
			help|http://wiki.thebiogrid.org/doku.php
			online documentation|https://www.youtube.com/channel/UCIdwfNwL9gi4oLBUqDB189g
			online documentation|https://github.com/BioGRID
			twitter|@biogrid
		After:
			blog|https://thebiogrid.org/
			help|http://wiki.thebiogrid.org/doku.php
			online documentation|https://www.youtube.com/channel/UCIdwfNwL9gi4oLBUqDB189g
			online documentation|https://github.com/BioGRID
			twitter|@biogrid
		Added:
			blog|https://thebiogrid.org/
		Removed:

Edits to 'https://fairsharing.org/FAIRsharing.9d5f5r' by 'The FAIRsharing Team' at 08:22, 03 Mar 2021 (approved):

	'organizations' has been modified:
		Before:
			Genome Canada, Canada|http://www.genomecanada.ca/|Funds
			Genome Quebec, Quebec, Canada|http://www.genomequebec.com|Funds
			U.S. National Library of Medicine|https://www.nlm.nih.gov/|Funds
			Canadian Institutes of Health Research (CIHR)|http://www.cihr-irsc.gc.ca/e/193.html|Funds
			National Institutes of Health Office of Research Infrastructure Programs|https://orip.nih.gov/|Funds
			Princeton University, NJ, USA|http://www.princeton.edu/main/|Maintains
			Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto M5G 1X5, Canada.|http://www.lunenfeld.ca|Maintains
			University of Edinburgh, UK|https://www.inf.ed.ac.uk/research/ianc/|Maintains
			University of Montreal, Canada|http://www.umontreal.ca/english/|Maintains
		After:
			U.S. National Library of Medicine|https://www.nlm.nih.gov/|Funds
			Canadian Institutes of Health Research (CIHR)|http://www.cihr-irsc.gc.ca/e/193.html|Funds
			National Institutes of Health Office of Research Infrastructure Programs|https://orip.nih.gov/|Funds
			Princeton University, NJ, USA|http://www.princeton.edu/main/|Maintains
			Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto M5G 1X5, Canada.|http://www.lunenfeld.ca|Maintains
			University of Edinburgh, UK|https://www.inf.ed.ac.uk/research/ianc/|Maintains
			University of Montreal, Canada|http://www.umontreal.ca/english/|Maintains
		Added:
		Removed:
			Genome Canada, Canada|http://www.genomecanada.ca/|Funds
			Genome Quebec, Quebec, Canada|http://www.genomequebec.com|Funds

	'taxonomies' has been modified:
		Before:
			Arabidopsis thaliana
			Drosophila melanogaster
			Homo sapiens
			Saccharomyces cerevisiae
			Schizosaccharomyces pombe
		After:
			Arabidopsis thaliana
			Bos taurus
			Caenorhabditis elegans
			Candida albicans
			Drosophila melanogaster
			Escherichia coli K12
			Gallus gallus
			Hepatitis C virus
			Homo sapiens
			Human immunodeficiency virus
			Mus musculus
			Plasmodium falciparum
			Rattus norvegicus
			SARS-CoV-2
			Saccharomyces cerevisiae
			Schizosaccharomyces pombe
			Xenopus laevis
		Added:
			Bos taurus
			Caenorhabditis elegans
			Candida albicans
			Escherichia coli K12
			Gallus gallus
			Hepatitis C virus
			Human immunodeficiency virus
			Mus musculus
			Plasmodium falciparum
			Rattus norvegicus
			SARS-CoV-2
			Xenopus laevis
		Removed:

	'supportLinks' has been modified:
		Before:
			help|http://wiki.thebiogrid.org/doku.php
			twitter|@biogrid
		After:
			help|http://wiki.thebiogrid.org/doku.php
			online documentation|https://www.youtube.com/channel/UCIdwfNwL9gi4oLBUqDB189g
			online documentation|https://github.com/BioGRID
			twitter|@biogrid
		Added:
			online documentation|https://www.youtube.com/channel/UCIdwfNwL9gi4oLBUqDB189g
			online documentation|https://github.com/BioGRID
		Removed:

	'description' has been modified:
		Before: BioGRID is an interaction repository with data compiled through comprehensive curation efforts. Our current index is version 3.5.174 and searches 69,922 publications for 1,706,694 protein and genetic interactions, 28,093 chemical associations and 726,378 post translational modifications from major model organism species. All data are freely provided via our search index and available for download in standardized formats.
		After: The Biological General Repository for Interaction Datasets (BioGRID) is a public database that archives and disseminates genetic and protein interaction data from model organisms and humans. BioGRID currently holds over?1,740,000 interactions?curated from both high-throughput datasets and individual focused studies, as derived from over 70,000+ publications in the primary literature. Complete coverage of the entire literature is maintained for budding yeast (S. cerevisiae), fission yeast (S. pombe) and thale cress (A. thaliana), and efforts to expand curation across multiple metazoan species are underway. 
All data are freely provided via our search index and available for download in many standardized formats.

	'dataProcesses' has been modified:
		Before:
			Download, data access, http://thebiogrid.org/download.php
			RESTful Web Service Listing, data access, http://wiki.thebiogrid.org/doku.php/biogridrest
		After:
			Download, data access, http://thebiogrid.org/download.php
			Advanced search, data access, http://wiki.thebiogrid.org/doku.php/advanced_search
			Submit, data curation, http://wiki.thebiogrid.org/doku.php/contribute
		Added:
			Advanced search, data access, http://wiki.thebiogrid.org/doku.php/advanced_search
			Submit, data curation, http://wiki.thebiogrid.org/doku.php/contribute
		Removed:
			RESTful Web Service Listing, data access, http://wiki.thebiogrid.org/doku.php/biogridrest

	'publications' has been modified:
		Before:
			BioGRID: a general repository for interaction datasets.|Stark C., Breitkreutz BJ., Reguly T., Boucher L., Breitkreutz A., Tyers M., |Nucleic Acids Res.|2006
			The GRID: the General Repository for Interaction Datasets.|Breitkreutz BJ,Stark C,Tyers M|Genome Biol|2003
			The BioGRID interaction database: 2019 update|Oughtred R, Stark C, Breitkreutz BJ, Rust J, Boucher L, Chang C, Kolas N, O'Donnell L, Leung G, McAdam R, Zhang F, Dolma S, Willems A, Coulombe-Huntington J, Chatr-Aryamontri A, Dolinski K, Tyers M|Nucleic Acids Res|2019
		After:
			BioGRID: a general repository for interaction datasets.|Stark C., Breitkreutz BJ., Reguly T., Boucher L., Breitkreutz A., Tyers M., |Nucleic Acids Res.|2006
			The GRID: the General Repository for Interaction Datasets.|Breitkreutz BJ,Stark C,Tyers M|Genome Biol|2003
			The BioGRID interaction database: 2019 update|Oughtred R, Stark C, Breitkreutz BJ, Rust J, Boucher L, Chang C, Kolas N, O'Donnell L, Leung G, McAdam R, Zhang F, Dolma S, Willems A, Coulombe-Huntington J, Chatr-Aryamontri A, Dolinski K, Tyers M|Nucleic Acids Res|2019
			The BioGRID database: A comprehensive biomedical resource of curated protein, genetic, and chemical interactions.|Oughtred R,Rust J,Chang C,Breitkreutz BJ,Stark C,Willems A,Boucher L,Leung G,Kolas N,Zhang F,Dolma S,Coulombe-Huntington J,Chatr-Aryamontri A,Dolinski K,Tyers M|Protein Sci|2020
		Added:
			The BioGRID database: A comprehensive biomedical resource of curated protein, genetic, and chemical interactions.|Oughtred R,Rust J,Chang C,Breitkreutz BJ,Stark C,Willems A,Boucher L,Leung G,Kolas N,Zhang F,Dolma S,Coulombe-Huntington J,Chatr-Aryamontri A,Dolinski K,Tyers M|Protein Sci|2020
		Removed:

	'accessPoints' has been modified:
		Before:
			REST|https://webservice.thebiogrid.org/|Retrieval of BioGRID interaction data
		After:
			REST|https://webservice.thebiogrid.org/|Retrieval of BioGRID interaction data
			REST|http://wiki.thebiogrid.org/doku.php/biogridrest|RESTful Web Service Listing
		Added:
			REST|http://wiki.thebiogrid.org/doku.php/biogridrest|RESTful Web Service Listing
		Removed:

	'tools' has been modified:
		Before:
			advanced search||http://wiki.thebiogrid.org/doku.php/advanced_search
			submit||http://wiki.thebiogrid.org/doku.php/contribute
			ProHits||http://prohitsms.com/Prohits_download/list.php
			GeneMania||http://genemania.org
			Cytoscape||http://www.cytoscape.org
			esyN||http://www.esyn.org
			ORCS (BioGRID Open Repository of CRISPR Screens)||https://orcs.thebiogrid.org/
		After:
			ProHits||http://prohitsms.com/Prohits_download/list.php
			GeneMania||http://genemania.org
			Cytoscape||http://www.cytoscape.org
			ORCS (BioGRID Open Repository of CRISPR Screens)||https://orcs.thebiogrid.org/
			BioGRID Plugin| 2.0|https://wiki.thebiogrid.org/doku.php/biogridplugin2
			BioGRID TAB File Loader Plugin for Cytoscape||https://wiki.thebiogrid.org/doku.php/biogrid_tab_file_loader_plugin
		Added:
			BioGRID Plugin| 2.0|https://wiki.thebiogrid.org/doku.php/biogridplugin2
			BioGRID TAB File Loader Plugin for Cytoscape||https://wiki.thebiogrid.org/doku.php/biogrid_tab_file_loader_plugin
		Removed:
			advanced search||http://wiki.thebiogrid.org/doku.php/advanced_search
			submit||http://wiki.thebiogrid.org/doku.php/contribute
			esyN||http://www.esyn.org

Edits to 'https://fairsharing.org/FAIRsharing.9d5f5r' by 'AndrewWillems' at 00:18, 27 Jul 2019 (approved):

	'organizations' has been modified:
		Before:
			Genome Canada, Canada|http://www.genomecanada.ca/|Funds
			Genome Quebec, Quebec, Canada|http://www.genomequebec.com|Funds
			Princeton University, NJ, USA|http://www.princeton.edu/main/|Maintains
			Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto M5G 1X5, Canada.|http://www.lunenfeld.ca|Maintains
			University of Edinburgh, UK|https://www.inf.ed.ac.uk/research/ianc/|Maintains
			University of Montreal, Canada|http://www.umontreal.ca/english/|Maintains
			U.S. National Library of Medicine|https://www.nlm.nih.gov/|Funds
			Canadian Institutes of Health Research (CIHR)|http://www.cihr-irsc.gc.ca/e/193.html|Funds
		After:
			Genome Canada, Canada|http://www.genomecanada.ca/|Funds
			Genome Quebec, Quebec, Canada|http://www.genomequebec.com|Funds
			U.S. National Library of Medicine|https://www.nlm.nih.gov/|Funds
			Canadian Institutes of Health Research (CIHR)|http://www.cihr-irsc.gc.ca/e/193.html|Funds
			Princeton University, NJ, USA|http://www.princeton.edu/main/|Maintains
			Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto M5G 1X5, Canada.|http://www.lunenfeld.ca|Maintains
			University of Edinburgh, UK|https://www.inf.ed.ac.uk/research/ianc/|Maintains
			University of Montreal, Canada|http://www.umontreal.ca/english/|Maintains
			National Institutes of Health Office of Research Infrastructure Programs|https://orip.nih.gov/|Funds
		Added:
			National Institutes of Health Office of Research Infrastructure Programs|https://orip.nih.gov/|Funds
		Removed:

	'taxonomies' has been modified:
		Before:
			Arabidopsis thaliana
			Drosophila melanogaster
			Saccharomyces cerevisiae
			Schizosaccharomyces pombe
		After:
			Arabidopsis thaliana
			Drosophila melanogaster
			Homo sapiens
			Saccharomyces cerevisiae
			Schizosaccharomyces pombe
		Added:
			Homo sapiens
		Removed:

	'description' has been modified:
		Before: BioGRID is an interaction repository with data compiled through comprehensive curation efforts. BioGRID currently holds over 980,000 interactions curated from both high-throughput datasets and individual focused studies, as derived from over 55,000 publications in the primary literature. Complete coverage of the entire literature is maintained for budding year (S. cerevisiae), fission yeast (S. pome), and thale cress (A. thaliana), and efforts to expand curation across multiple metazoan species are underway. All data are freely provided via the search index and available for download in standardized formats.
		After: BioGRID is an interaction repository with data compiled through comprehensive curation efforts. Our current index is version 3.5.174 and searches 69,922 publications for 1,706,694 protein and genetic interactions, 28,093 chemical associations and 726,378 post translational modifications from major model organism species. All data are freely provided via our search index and available for download in standardized formats.

	'user_defined_tags' has been modified:
		Before:
		After:
			Physical interaction
		Added:
			Physical interaction
		Removed:

	'onto_disciplines' has been modified:
		Before:
			Life Sciences
		After:
			Biochemistry
			Bioinformatics
			Chemical Biology
			Cheminformatics
			Life Sciences
			Proteomics
			Systems biology
		Added:
			Biochemistry
			Bioinformatics
			Chemical Biology
			Cheminformatics
			Proteomics
			Systems biology
		Removed:

	'onto_domains' has been modified:
		Before:
			gene
			molecular interaction
			protein
		After:
			Biocuration
			Protein interactions
			Protein-Protein Interaction
			gene
			interactome
			molecular interaction
			post-translational protein modification
			protein
			protein modification process
			regulation of post-translational protein modification
		Added:
			Biocuration
			Protein interactions
			Protein-Protein Interaction
			interactome
			post-translational protein modification
			protein modification process
			regulation of post-translational protein modification
		Removed:

	'grants' has been modified:
		Before:
			R01 RR024031
		After:
			R01 OD010929
		Added:
			R01 OD010929
		Removed:
			R01 RR024031

	'publications' has been modified:
		Before:
			BioGRID: a general repository for interaction datasets.|Stark C., Breitkreutz BJ., Reguly T., Boucher L., Breitkreutz A., Tyers M., |Nucleic Acids Res.|2006
			The GRID: the General Repository for Interaction Datasets.|Breitkreutz BJ,Stark C,Tyers M|Genome Biol|2003
		After:
			BioGRID: a general repository for interaction datasets.|Stark C., Breitkreutz BJ., Reguly T., Boucher L., Breitkreutz A., Tyers M., |Nucleic Acids Res.|2006
			The GRID: the General Repository for Interaction Datasets.|Breitkreutz BJ,Stark C,Tyers M|Genome Biol|2003
			The BioGRID interaction database: 2019 update|Oughtred R, Stark C, Breitkreutz BJ, Rust J, Boucher L, Chang C, Kolas N, O'Donnell L, Leung G, McAdam R, Zhang F, Dolma S, Willems A, Coulombe-Huntington J, Chatr-Aryamontri A, Dolinski K, Tyers M|Nucleic Acids Res|2019
		Added:
			The BioGRID interaction database: 2019 update|Oughtred R, Stark C, Breitkreutz BJ, Rust J, Boucher L, Chang C, Kolas N, O'Donnell L, Leung G, McAdam R, Zhang F, Dolma S, Willems A, Coulombe-Huntington J, Chatr-Aryamontri A, Dolinski K, Tyers M|Nucleic Acids Res|2019
		Removed:

	'accessPoints' has been modified:
		Before:
		After:
			REST|https://webservice.thebiogrid.org/|Retrieval of BioGRID interaction data
		Added:
			REST|https://webservice.thebiogrid.org/|Retrieval of BioGRID interaction data
		Removed:

	'tools' has been modified:
		Before:
			advanced search||http://wiki.thebiogrid.org/doku.php/advanced_search
			submit||http://wiki.thebiogrid.org/doku.php/contribute
			Osprey||http://biodata.mshri.on.ca/osprey/servlet/Index
			ProHits||http://prohitsms.com/Prohits_download/list.php
			GeneMania||http://genemania.org
			Cytoscape||http://www.cytoscape.org
			esyN||http://www.esyn.org
		After:
			advanced search||http://wiki.thebiogrid.org/doku.php/advanced_search
			submit||http://wiki.thebiogrid.org/doku.php/contribute
			ProHits||http://prohitsms.com/Prohits_download/list.php
			GeneMania||http://genemania.org
			Cytoscape||http://www.cytoscape.org
			esyN||http://www.esyn.org
			ORCS (BioGRID Open Repository of CRISPR Screens)||https://orcs.thebiogrid.org/
		Added:
			ORCS (BioGRID Open Repository of CRISPR Screens)||https://orcs.thebiogrid.org/
		Removed:
			Osprey||http://biodata.mshri.on.ca/osprey/servlet/Index

Edits to 'https://fairsharing.org/FAIRsharing.9d5f5r' by 'The FAIRsharing Team' at 19:40, 11 Jan 2018 (approved):

	'domains' has been modified:
		Before:
			Gene|property|http://purl.obolibrary.org/obo/SO_0000704
			Life Science|domain|http://www.fairsharing.org/ontology/SRAO_0000069
			Molecular interactions|pathways and networks||http://edamontology.org/topic_0602
			Protein|None|http://purl.obolibrary.org/obo/PR_000000001
		After:
			Gene|property|http://purl.obolibrary.org/obo/SO_0000704
			Life Science|domain|http://www.fairsharing.org/ontology/SRAO_0000069
			Protein|None|http://purl.obolibrary.org/obo/PR_000000001
			Molecular interaction|process|http://purl.obolibrary.org/obo/MI_0000
		Added:
			Molecular interaction|process|http://purl.obolibrary.org/obo/MI_0000
		Removed:
			Molecular interactions|pathways and networks||http://edamontology.org/topic_0602

In Collections

NIH-supported data repositories

Data Citation Implementation

Open Science Prize

COVID-19 Resources

Support

General

blog	Latest news
help	Help and Support Resources
online documentation	Youtube
online documentation	GitHub
twitter	@biogrid

Additional Information

Contact

biogridadmin@gmail.com

Tools

ProHits	http://prohitsms.com/Prohits_download/list.php
GeneMania	http://genemania.org
Cytoscape	http://www.cytoscape.org
ORCS (BioGRID Open Repository of CRISPR Screens)	https://orcs.thebiogrid.org/
BioGRID Plugin	https://wiki.thebiogrid.org/doku.php/biogridplugin2	2.0
BioGRID TAB File Loader Plugin for Cytoscape	https://wiki.thebiogrid.org/doku.php/biogrid_tab_file_loader_plugin

Access / Retrieve Data

Conditions of Use

Applies to: Data use

BioGRID Terms and Conditions

Data Curation

Submit

http://wiki.thebiogrid.org/doku.php/contribute

Data Access

Download	http://thebiogrid.org/download.php
Advanced search	http://wiki.thebiogrid.org/doku.php/advanced_search

REST Web Services

Retrieval of BioGRID interaction data	https://webservice.thebiogrid.org/
RESTful Web Service Listing	http://wiki.thebiogrid.org/doku.php/biogridrest

Publications

BioGRID: a general repository for interaction datasets.

Stark C., Breitkreutz BJ., Reguly T., Boucher L., Breitkreutz A., Tyers M.,
Nucleic Acids Res. 2006

View Paper (PubMed)

The GRID: the General Repository for Interaction Datasets.

Breitkreutz BJ,Stark C,Tyers M
Genome Biol 2003

View Paper (PubMed)

The BioGRID interaction database: 2019 update

Oughtred R, Stark C, Breitkreutz BJ, Rust J, Boucher L, Chang C, Kolas N, O'Donnell L, Leung G, McAdam R, Zhang F, Dolma S, Willems A, Coulombe-Huntington J, Chatr-Aryamontri A, Dolinski K, Tyers M
Nucleic Acids Res 2019

View Paper (PubMed) View Publication

The BioGRID database: A comprehensive biomedical resource of curated protein, genetic, and chemical interactions.

Oughtred R,Rust J,Chang C,Breitkreutz BJ,Stark C,Willems A,Boucher L,Leung G,Kolas N,Zhang F,Dolma S,Coulombe-Huntington J,Chatr-Aryamontri A,Dolinski K,Tyers M
Protein Sci 2020

View Paper (PubMed) View Publication

Related Standards

Reporting Guidelines

Common Metadata Elements for Cataloging Biomedical Datasets

Terminology Artifacts

Models and Formats

Identifier Schemas

No identifier schema standards defined

Metrics

No metrics standards defined

Related Databases

Implementing Policies

Credit

Record Maintainer

This record is maintained by AndrewWillems ORCID

Funds

U.S. National Library of Medicine (Government body)
Canadian Institutes of Health Research (CIHR) (Government body)
National Institutes of Health Office of Research Infrastructure Programs (Government body)

Maintains

Princeton University, NJ, USA (University)
Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto M5G 1X5, Canada. (Research institute)
University of Edinburgh, UK (University)
University of Montreal, Canada (University)

Grant Number(s)

R01 OD010929 (National Institutes of Health Office of Research Infrastructure Programs)

Biological General Repository for Interaction Datasets

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