CATH Protein Structure Classification

Abbreviation:CATH domain

General Information

The CATH database is a hierarchical domain classification of protein structures in the Protein Data Bank. Protein structures are classified using a combination of automated and manual procedures. There are four major levels in this hierarchy; Class (secondary structure classification, e.g. mostly alpha), Architecture (classification based on overall shape), Topology (fold family) and Homologous superfamily (protein domains which are thought to share a common ancestor). This collection is concerned with superfamily classification.

Homepage http://www.cathdb.info/

Countries that developed this resource United Kingdom

Created in 1996

Taxonomic range

All

Knowledge Domains

Subjects

How to cite this record FAIRsharing.org: CATH domain; CATH Protein Structure Classification; DOI: https://doi.org/10.25504/FAIRsharing.xgcyyn; Last edited: Jan. 8, 2019, 1:20 p.m.; Last accessed: Aug 22 2019 9:28 p.m.

Publication for citation CATH: an expanded resource to predict protein function through structure and sequence. Dawson NL,Lewis TE,Das S,Lees JG,Lee D,Ashford P,Orengo CA,Sillitoe I; Nucleic Acids Res ; 2016; 10.1093/nar/gkw1098;

This record is maintained by isillitoe ORCID

Record updated: Dec. 21, 2018, 10:52 a.m. by The FAIRsharing Team.

Show edit history

Edits to 'https://fairsharing.org/FAIRsharing.xgcyyn' by 'The FAIRsharing Team' at 10:52, 21 Dec 2018 (approved):

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			FAQ|http://www.cathdb.info/wiki/doku/?id=faq
			blog|http://orengogroup.info/
			email|cathteam@biochem.ucl.ac.uk
			forum|http://orengogroup.info/
			help|http://www.cathdb.info/wiki
			twitter|@CATHDatabase
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			FAQ|http://www.cathdb.info/wiki/doku/?id=faq
			blog|http://orengogroup.info/
			email|cathteam@biochem.ucl.ac.uk
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			CATH--a hierarchic classification of protein domain structures.|Orengo CA., Michie AD., Jones S., Jones DT., Swindells MB., Thornton JM., |Structure|1997
			Functional classification of CATH superfamilies: a domain-based approach for protein function annotation.|Das S,Lee D,Sillitoe I,Dawson NL,Lees JG,Orengo CA|Bioinformatics|2016
			The history of the CATH structural classification of protein domains.|Sillitoe I,Dawson N,Thornton J,Orengo C|Biochimie|2015
			CATH: comprehensive structural and functional annotations for genome sequences.|Sillitoe I,Lewis TE,Cuff A,Das S,Ashford P,Dawson NL,Furnham N,Laskowski RA,Lee D,Lees JG,Lehtinen S,Studer RA,Thornton J,Orengo CA|Nucleic Acids Res|2014
			The CATH protein family database: a resource for structural and functional annotation of genomes.|Orengo CA,Bray JE,Buchan DW,Harrison A,Lee D,Pearl FM,Sillitoe I,Todd AE,Thornton JM|Proteomics|2002
		After:
			CATH--a hierarchic classification of protein domain structures.|Orengo CA., Michie AD., Jones S., Jones DT., Swindells MB., Thornton JM., |Structure|1997
			Functional classification of CATH superfamilies: a domain-based approach for protein function annotation.|Das S,Lee D,Sillitoe I,Dawson NL,Lees JG,Orengo CA|Bioinformatics|2016
			The history of the CATH structural classification of protein domains.|Sillitoe I,Dawson N,Thornton J,Orengo C|Biochimie|2015
			CATH: comprehensive structural and functional annotations for genome sequences.|Sillitoe I,Lewis TE,Cuff A,Das S,Ashford P,Dawson NL,Furnham N,Laskowski RA,Lee D,Lees JG,Lehtinen S,Studer RA,Thornton J,Orengo CA|Nucleic Acids Res|2014
			The CATH protein family database: a resource for structural and functional annotation of genomes.|Orengo CA,Bray JE,Buchan DW,Harrison A,Lee D,Pearl FM,Sillitoe I,Todd AE,Thornton JM|Proteomics|2002
			CATH: an expanded resource to predict protein function through structure and sequence.|Dawson NL,Lewis TE,Das S,Lees JG,Lee D,Ashford P,Orengo CA,Sillitoe I|Nucleic Acids Res|2016
			Gene3D: Extensive prediction of globular domains in proteins.|Lewis TE,Sillitoe I,Dawson N,Lam SD,Clarke T,Lee D,Orengo C,Lees J|Nucleic Acids Res|2017
		Added:
			CATH: an expanded resource to predict protein function through structure and sequence.|Dawson NL,Lewis TE,Das S,Lees JG,Lee D,Ashford P,Orengo CA,Sillitoe I|Nucleic Acids Res|2016
			Gene3D: Extensive prediction of globular domains in proteins.|Lewis TE,Sillitoe I,Dawson N,Lam SD,Clarke T,Lee D,Orengo C,Lees J|Nucleic Acids Res|2017
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Edits to 'https://fairsharing.org/FAIRsharing.xgcyyn' by 'The FAIRsharing Team' at 18:22, 30 Jul 2018 (approved):

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			Attribution required||Data
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			help|http://www.cathdb.info/wiki
			twitter|@CATHDatabase
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			FAQ|http://www.cathdb.info/wiki/doku/?id=faq
			blog|http://orengogroup.info/
			email|cathteam@biochem.ucl.ac.uk
			forum|http://orengogroup.info/
			help|http://www.cathdb.info/wiki
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			cath-tools||https://github.com/UCLOrengoGroup/cath-tools
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			MAFFT||https://mafft.cbrc.jp/alignment/software/
			Scorecons||https://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/valdar/scorecons_server.pl
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			cath-tools||https://github.com/UCLOrengoGroup/cath-tools
			BLAST||https://blast.ncbi.nlm.nih.gov/Blast.cgi
			HUMMER||http://hmmer.org
			MAFFT||https://mafft.cbrc.jp/alignment/software/
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In Collections

ELIXIR Core Data Resources and Deposition Databases

ELIXIR UK node resources

Support

General

FAQ	FAQ
blog	Group Site and Blog
support email	Contact CATH
help	About CATH
twitter	@CATHDatabase

Additional Information

Contact	Ian Sillitoe
Identifiers.org	MIR:00000210

Tools

cath-tools	https://github.com/UCLOrengoGroup/cath-tools
BLAST	https://blast.ncbi.nlm.nih.gov/Blast.cgi
HUMMER	http://hmmer.org
MAFFT	https://mafft.cbrc.jp/alignment/software/
Scorecons	https://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/valdar/scorecons_ ...

Access / Retrieve Data

Conditions of Use

Applies to: Data use

Attribution required
Publicly available data
CATH Privacy Policy

Data Access

Download	http://www.cathdb.info/download
Browse	http://www.cathdb.info/browse/tree
Search	http://www.cathdb.info/search
Search by Sequence	http://www.cathdb.info/search/by_sequence

Publications

CATH--a hierarchic classification of protein domain structures.

Orengo CA., Michie AD., Jones S., Jones DT., Swindells MB., Thornton JM.,
Structure 1997

View Paper (PubMed)

Functional classification of CATH superfamilies: a domain-based approach for protein function annotation.

Das S,Lee D,Sillitoe I,Dawson NL,Lees JG,Orengo CA
Bioinformatics 2016