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CATH

General Information

The CATH database is a free, publicly available online resource that provides information on the evolutionary relationships of protein domains. It provides a hierarchical domain classification of protein structures in the Protein Data Bank. Protein structures are classified using a combination of automated and manual procedures. There are four major levels in this hierarchy; Class (secondary structure classification, e.g. mostly alpha), Architecture (classification based on overall shape), Topology (fold family) and Homologous superfamily (protein domains which are thought to share a common ancestor).

Homepage http://www.cathdb.info/

Countries that developed this resource United Kingdom

Created in 1996

Taxonomic range

All

Knowledge Domains

Subjects

How to cite this record FAIRsharing.org: CATH; CATH; DOI: https://doi.org/10.25504/FAIRsharing.xgcyyn; Last edited: March 7, 2021, 8:33 p.m.; Last accessed: Sep 20 2021 9:36 p.m.

Publication for citation CATH: increased structural coverage of functional space. Sillitoe I,Bordin N,Dawson N,Waman VP,Ashford P,Scholes HM,Pang CSM,Woodridge L,Rauer C,Sen N,Abbasian M,Le Cornu S,Lam SD,Berka K,Varekova IH,Svobodova R,Lees J,Orengo CA; Nucleic Acids Res ; 2020; 10.1093/nar/gkaa1079 ;

This record is maintained by isillitoe ORCID

Record updated: March 7, 2021, 8:31 p.m. by The FAIRsharing Team.

Show edit history

Edits to 'https://fairsharing.org/FAIRsharing.xgcyyn' by 'The FAIRsharing Team' at 20:32, 07 Mar 2021 (approved):

	'shortname' has been modified:
		Before: CATH domain
		After: CATH

	'related_databases' has been modified:
		Before:
			FunTree: A Resource For Exploring The Functional Evolution Of Structurally Defined Enzyme Superfamilies
			Mechanism, Annotation and Classification in Enzymes
			ProtoNet
			Statistical Torsional Angles Potentials of NMR Refinement Database
			Gene3D
			MetalPDB
			PROCOGNATE
			MobiDB
			Mechanism and Catalytic Site Atlas
			Genome3D
			Allosteric Mutation Analysis and Polymorphism of Signaling database
			TargetMine
			Protein Data Bank in Europe - Knowledge Base
		After:
			FunTree: A Resource For Exploring The Functional Evolution Of Structurally Defined Enzyme Superfamilies
			Mechanism, Annotation and Classification in Enzymes
			ProtoNet
			Statistical Torsional Angles Potentials of NMR Refinement Database
			Gene3D
			MetalPDB
			Integrated resource of protein families, domains and functional sites
			PROCOGNATE
			Structural Classification Of Proteins
			MobiDB
			Mechanism and Catalytic Site Atlas
			Genome3D
			Allosteric Mutation Analysis and Polymorphism of Signaling database
			TargetMine
			Protein Data Bank in Europe - Knowledge Base
		Added:
			Integrated resource of protein families, domains and functional sites
			Structural Classification Of Proteins
		Removed:

	'name' has been modified:
		Before: CATH Protein Structure Classification
		After: CATH

	'publications' has been modified:
		Before:
			CATH--a hierarchic classification of protein domain structures.|Orengo CA., Michie AD., Jones S., Jones DT., Swindells MB., Thornton JM., |Structure|1997
			Functional classification of CATH superfamilies: a domain-based approach for protein function annotation.|Das S,Lee D,Sillitoe I,Dawson NL,Lees JG,Orengo CA|Bioinformatics|2016
			The history of the CATH structural classification of protein domains.|Sillitoe I,Dawson N,Thornton J,Orengo C|Biochimie|2015
			CATH: comprehensive structural and functional annotations for genome sequences.|Sillitoe I,Lewis TE,Cuff A,Das S,Ashford P,Dawson NL,Furnham N,Laskowski RA,Lee D,Lees JG,Lehtinen S,Studer RA,Thornton J,Orengo CA|Nucleic Acids Res|2014
			The CATH protein family database: a resource for structural and functional annotation of genomes.|Orengo CA,Bray JE,Buchan DW,Harrison A,Lee D,Pearl FM,Sillitoe I,Todd AE,Thornton JM|Proteomics|2002
			CATH: an expanded resource to predict protein function through structure and sequence.|Dawson NL,Lewis TE,Das S,Lees JG,Lee D,Ashford P,Orengo CA,Sillitoe I|Nucleic Acids Res|2016
			Gene3D: Extensive prediction of globular domains in proteins.|Lewis TE,Sillitoe I,Dawson N,Lam SD,Clarke T,Lee D,Orengo C,Lees J|Nucleic Acids Res|2017
		After:
			CATH--a hierarchic classification of protein domain structures.|Orengo CA., Michie AD., Jones S., Jones DT., Swindells MB., Thornton JM., |Structure|1997
			Functional classification of CATH superfamilies: a domain-based approach for protein function annotation.|Das S,Lee D,Sillitoe I,Dawson NL,Lees JG,Orengo CA|Bioinformatics|2016
			The history of the CATH structural classification of protein domains.|Sillitoe I,Dawson N,Thornton J,Orengo C|Biochimie|2015
			CATH: comprehensive structural and functional annotations for genome sequences.|Sillitoe I,Lewis TE,Cuff A,Das S,Ashford P,Dawson NL,Furnham N,Laskowski RA,Lee D,Lees JG,Lehtinen S,Studer RA,Thornton J,Orengo CA|Nucleic Acids Res|2014
			The CATH protein family database: a resource for structural and functional annotation of genomes.|Orengo CA,Bray JE,Buchan DW,Harrison A,Lee D,Pearl FM,Sillitoe I,Todd AE,Thornton JM|Proteomics|2002
			CATH: an expanded resource to predict protein function through structure and sequence.|Dawson NL,Lewis TE,Das S,Lees JG,Lee D,Ashford P,Orengo CA,Sillitoe I|Nucleic Acids Res|2016
			Gene3D: Extensive prediction of globular domains in proteins.|Lewis TE,Sillitoe I,Dawson N,Lam SD,Clarke T,Lee D,Orengo C,Lees J|Nucleic Acids Res|2017
			CATH: expanding the horizons of structure-based functional annotations for genome sequences.|Sillitoe I,Dawson N,Lewis TE,Das S,Lees JG,Ashford P,Tolulope A,Scholes HM,Senatorov I,Bujan A,Ceballos Rodriguez-Conde F,Dowling B,Thornton J,Orengo CA|Nucleic Acids Res|2018
			CATH: increased structural coverage of functional space.|Sillitoe I,Bordin N,Dawson N,Waman VP,Ashford P,Scholes HM,Pang CSM,Woodridge L,Rauer C,Sen N,Abbasian M,Le Cornu S,Lam SD,Berka K,Varekova IH,Svobodova R,Lees J,Orengo CA|Nucleic Acids Res|2020
		Added:
			CATH: expanding the horizons of structure-based functional annotations for genome sequences.|Sillitoe I,Dawson N,Lewis TE,Das S,Lees JG,Ashford P,Tolulope A,Scholes HM,Senatorov I,Bujan A,Ceballos Rodriguez-Conde F,Dowling B,Thornton J,Orengo CA|Nucleic Acids Res|2018
			CATH: increased structural coverage of functional space.|Sillitoe I,Bordin N,Dawson N,Waman VP,Ashford P,Scholes HM,Pang CSM,Woodridge L,Rauer C,Sen N,Abbasian M,Le Cornu S,Lam SD,Berka K,Varekova IH,Svobodova R,Lees J,Orengo CA|Nucleic Acids Res|2020
		Removed:

Edits to 'https://fairsharing.org/FAIRsharing.xgcyyn' by 'The FAIRsharing Team' at 20:27, 07 Mar 2021 (approved):

	'organizations' has been modified:
		Before:
			Medical Research Council (MRC), London, UK|http://www.emouseatlas.org/emap/home.html|Funds
			Biotechnology and Biological Sciences Research Council (BBSRC), UK|https://bbsrc.ukri.org|Funds
			The Wellcome Trust, UK|https://wellcome.ac.uk/|Funds
			The European Research Council (ERC)|https://erc.europa.eu/|Funds
			University College London, UK|http://www.ucl.ac.uk/smb|Maintains
			National Institutes of Health (NIH), Bethesda, MD, USA|https://www.nih.gov/|Funds
		After:
			Medical Research Council (MRC), London, UK|http://www.emouseatlas.org/emap/home.html|Funds
			Biotechnology and Biological Sciences Research Council (BBSRC), UK|https://bbsrc.ukri.org|Funds
			The Wellcome Trust, UK|https://wellcome.ac.uk/|Funds
			The European Research Council (ERC)|https://erc.europa.eu/|Funds
			National Institutes of Health (NIH), Bethesda, MD, USA|https://www.nih.gov/|Funds
			Research Department of Structural and Molecular Biology, Institute of Structural and Molecular Biology, University College London, Darwin Building, Gower St, London. WC1E 6BT, UK.|http://www.ucl.ac.uk/smb|Maintains
		Added:
			Research Department of Structural and Molecular Biology, Institute of Structural and Molecular Biology, University College London, Darwin Building, Gower St, London. WC1E 6BT, UK.|http://www.ucl.ac.uk/smb|Maintains
		Removed:
			University College London, UK|http://www.ucl.ac.uk/smb|Maintains

	'supportLinks' has been modified:
		Before:
			FAQ|http://www.cathdb.info/wiki/doku/?id=faq
			blog|http://orengogroup.info/
			email|cathteam@biochem.ucl.ac.uk
			help|http://www.cathdb.info/wiki
			twitter|@CATHDatabase
		After:
			FAQ|http://www.cathdb.info/wiki/doku/?id=faq
			blog|http://orengogroup.info/
			email|cathteam@biochem.ucl.ac.uk
			help|http://www.cathdb.info/wiki
			help|http://www.cathdb.info/support/contact
			twitter|@CATHDatabase
		Added:
			help|http://www.cathdb.info/support/contact
		Removed:

	'description' has been modified:
		Before: The CATH database is a hierarchical domain classification of protein structures in the Protein Data Bank. Protein structures are classified using a combination of automated and manual procedures. There are four major levels in this hierarchy; Class (secondary structure classification, e.g. mostly alpha), Architecture (classification based on overall shape), Topology (fold family) and  Homologous superfamily (protein domains which are thought to share a common ancestor). This collection is concerned with superfamily classification.
		After: The CATH database is a free, publicly available online resource that provides information on the evolutionary relationships of protein domains. It provides a hierarchical domain classification of protein structures in the Protein Data Bank. Protein structures are classified using a combination of automated and manual procedures. There are four major levels in this hierarchy; Class (secondary structure classification, e.g. mostly alpha), Architecture (classification based on overall shape), Topology (fold family) and Homologous superfamily (protein domains which are thought to share a common ancestor). 

	'licences' has been modified:
		Before:
			Attribution required||Data
			Publicly available data||Data
			CATH Privacy Policy|http://www.cathdb.info/wiki/doku/?id=privacy|Data
		After:
			CATH Privacy Policy|http://www.cathdb.info/wiki/doku/?id=privacy|Data
		Added:
		Removed:
			Attribution required||Data
			Publicly available data||Data

	'onto_disciplines' has been modified:
		Before:
			Life Science
		After:
			Biology
			Evolutionary Biology
		Added:
			Biology
			Evolutionary Biology
		Removed:
			Life Science

	'dataProcesses' has been modified:
		Before:
			Download, data access, http://www.cathdb.info/download
			Browse, data access, http://www.cathdb.info/browse/tree
			Search, data access, http://www.cathdb.info/search
			Search by Sequence, data access, http://www.cathdb.info/search/by_sequence
		After:
			Download, data release, http://www.cathdb.info/wiki?id=data:index
			Browse, data access, http://www.cathdb.info/browse/tree
			Search, data access, http://www.cathdb.info/search
			Search by Sequence, data access, http://www.cathdb.info/search/by_sequence
			Search by Structure, data access, http://www.cathdb.info/search/by_structure
		Added:
			Download, data release, http://www.cathdb.info/wiki?id=data:index
			Search by Structure, data access, http://www.cathdb.info/search/by_structure
		Removed:
			Download, data access, http://www.cathdb.info/download

	'onto_domains' has been modified:
		Before:
			Annotation
			Classification
			curated information
			protein
			structure
		After:
			Annotation
			Classification
			Evolution
			Structure
			curated information
			protein
			structure
		Added:
			Evolution
			Structure
		Removed:

	'tools' has been modified:
		Before:
			cath-tools||https://github.com/UCLOrengoGroup/cath-tools
			BLAST||https://blast.ncbi.nlm.nih.gov/Blast.cgi
			HUMMER||http://hmmer.org
			MAFFT||https://mafft.cbrc.jp/alignment/software/
			Scorecons||https://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/valdar/scorecons_server.pl
		After:
			Cath Tools GitHub Project||https://github.com/UCLOrengoGroup/cath-tools
		Added:
			Cath Tools GitHub Project||https://github.com/UCLOrengoGroup/cath-tools
		Removed:
			cath-tools||https://github.com/UCLOrengoGroup/cath-tools
			BLAST||https://blast.ncbi.nlm.nih.gov/Blast.cgi
			HUMMER||http://hmmer.org
			MAFFT||https://mafft.cbrc.jp/alignment/software/
			Scorecons||https://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/valdar/scorecons_server.pl

Edits to 'https://fairsharing.org/FAIRsharing.xgcyyn' by 'The FAIRsharing Team' at 10:52, 21 Dec 2018 (approved):

	'supportLinks' has been modified:
		Before:
			FAQ|http://www.cathdb.info/wiki/doku/?id=faq
			blog|http://orengogroup.info/
			email|cathteam@biochem.ucl.ac.uk
			forum|http://orengogroup.info/
			help|http://www.cathdb.info/wiki
			twitter|@CATHDatabase
		After:
			FAQ|http://www.cathdb.info/wiki/doku/?id=faq
			blog|http://orengogroup.info/
			email|cathteam@biochem.ucl.ac.uk
			help|http://www.cathdb.info/wiki
			twitter|@CATHDatabase
		Added:
		Removed:
			forum|http://orengogroup.info/

	'publications' has been modified:
		Before:
			CATH--a hierarchic classification of protein domain structures.|Orengo CA., Michie AD., Jones S., Jones DT., Swindells MB., Thornton JM., |Structure|1997
			Functional classification of CATH superfamilies: a domain-based approach for protein function annotation.|Das S,Lee D,Sillitoe I,Dawson NL,Lees JG,Orengo CA|Bioinformatics|2016
			The history of the CATH structural classification of protein domains.|Sillitoe I,Dawson N,Thornton J,Orengo C|Biochimie|2015
			CATH: comprehensive structural and functional annotations for genome sequences.|Sillitoe I,Lewis TE,Cuff A,Das S,Ashford P,Dawson NL,Furnham N,Laskowski RA,Lee D,Lees JG,Lehtinen S,Studer RA,Thornton J,Orengo CA|Nucleic Acids Res|2014
			The CATH protein family database: a resource for structural and functional annotation of genomes.|Orengo CA,Bray JE,Buchan DW,Harrison A,Lee D,Pearl FM,Sillitoe I,Todd AE,Thornton JM|Proteomics|2002
		After:
			CATH--a hierarchic classification of protein domain structures.|Orengo CA., Michie AD., Jones S., Jones DT., Swindells MB., Thornton JM., |Structure|1997
			Functional classification of CATH superfamilies: a domain-based approach for protein function annotation.|Das S,Lee D,Sillitoe I,Dawson NL,Lees JG,Orengo CA|Bioinformatics|2016
			The history of the CATH structural classification of protein domains.|Sillitoe I,Dawson N,Thornton J,Orengo C|Biochimie|2015
			CATH: comprehensive structural and functional annotations for genome sequences.|Sillitoe I,Lewis TE,Cuff A,Das S,Ashford P,Dawson NL,Furnham N,Laskowski RA,Lee D,Lees JG,Lehtinen S,Studer RA,Thornton J,Orengo CA|Nucleic Acids Res|2014
			The CATH protein family database: a resource for structural and functional annotation of genomes.|Orengo CA,Bray JE,Buchan DW,Harrison A,Lee D,Pearl FM,Sillitoe I,Todd AE,Thornton JM|Proteomics|2002
			CATH: an expanded resource to predict protein function through structure and sequence.|Dawson NL,Lewis TE,Das S,Lees JG,Lee D,Ashford P,Orengo CA,Sillitoe I|Nucleic Acids Res|2016
			Gene3D: Extensive prediction of globular domains in proteins.|Lewis TE,Sillitoe I,Dawson N,Lam SD,Clarke T,Lee D,Orengo C,Lees J|Nucleic Acids Res|2017
		Added:
			CATH: an expanded resource to predict protein function through structure and sequence.|Dawson NL,Lewis TE,Das S,Lees JG,Lee D,Ashford P,Orengo CA,Sillitoe I|Nucleic Acids Res|2016
			Gene3D: Extensive prediction of globular domains in proteins.|Lewis TE,Sillitoe I,Dawson N,Lam SD,Clarke T,Lee D,Orengo C,Lees J|Nucleic Acids Res|2017
		Removed:

	'dataProcesses' has been modified:
		Before:
			Download
			Browse
			Search
		After:
			Download
			Browse
			Search
			Search by Sequence
		Added:
			Search by Sequence
		Removed:

Edits to 'https://fairsharing.org/FAIRsharing.xgcyyn' by 'The FAIRsharing Team' at 18:22, 30 Jul 2018 (approved):

	'licences' has been modified:
		Before:
			Attribution required||Data
			Publicly available data||Data
		After:
			Attribution required||Data
			Publicly available data||Data
			CATH Privacy Policy|http://www.cathdb.info/wiki/doku/?id=privacy|Data
		Added:
			CATH Privacy Policy|http://www.cathdb.info/wiki/doku/?id=privacy|Data
		Removed:

	'supportLinks' has been modified:
		Before:
			blog|http://orengogroup.info/
			email|cathteam@biochem.ucl.ac.uk
			forum|http://orengogroup.info/
			help|http://www.cathdb.info/wiki
			twitter|@CATHDatabase
		After:
			FAQ|http://www.cathdb.info/wiki/doku/?id=faq
			blog|http://orengogroup.info/
			email|cathteam@biochem.ucl.ac.uk
			forum|http://orengogroup.info/
			help|http://www.cathdb.info/wiki
			twitter|@CATHDatabase
		Added:
			FAQ|http://www.cathdb.info/wiki/doku/?id=faq
		Removed:

	'tools' has been modified:
		Before:
		After:
			cath-tools||https://github.com/UCLOrengoGroup/cath-tools
			BLAST||https://blast.ncbi.nlm.nih.gov/Blast.cgi
			HUMMER||http://hmmer.org
			MAFFT||https://mafft.cbrc.jp/alignment/software/
			Scorecons||https://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/valdar/scorecons_server.pl
		Added:
			cath-tools||https://github.com/UCLOrengoGroup/cath-tools
			BLAST||https://blast.ncbi.nlm.nih.gov/Blast.cgi
			HUMMER||http://hmmer.org
			MAFFT||https://mafft.cbrc.jp/alignment/software/
			Scorecons||https://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/valdar/scorecons_server.pl
		Removed:

	'dataProcesses' has been modified:
		Before:
			Download
			Browse
			search
		After:
			Download
			Browse
			Search
		Added:
			Search
		Removed:
			search

Edits to 'https://fairsharing.org/FAIRsharing.xgcyyn' by 'The FAIRsharing Team' at 18:06, 07 Sep 2016 (approved):

	'contactName' has been modified:
		Before:
			
		After:
			Ian Sillitoe
		Added:
		Removed:

In Collections

EOSC-Life

Bioschemas

ELIXIR Core Data Resources and Deposition Databases

ELIXIR UK node resources

Support

General

FAQ	FAQ
blog	Orengo Group Site and Blog
support email	Contact CATH
help	CATH Wiki Pages
help	General Contact Information
twitter	@CATHDatabase

Additional Information

Contact

Ian Sillitoe

Tools

Cath Tools GitHub Project

https://github.com/UCLOrengoGroup/cath-tools

Access / Retrieve Data

Conditions of Use

Applies to: Data use

CATH Privacy Policy

Data Release

Download

http://www.cathdb.info/wiki?id=data:index

Data Access

Browse	http://www.cathdb.info/browse/tree
Search	http://www.cathdb.info/search
Search by Sequence	http://www.cathdb.info/search/by_sequence
Search by Structure	http://www.cathdb.info/search/by_structure

Publications

CATH--a hierarchic classification of protein domain structures.

Orengo CA., Michie AD., Jones S., Jones DT., Swindells MB., Thornton JM.,
Structure 1997

View Paper (PubMed)

Functional classification of CATH superfamilies: a domain-based approach for protein function annotation.

Das S,Lee D,Sillitoe I,Dawson NL,Lees JG,Orengo CA
Bioinformatics 2016