databases > DOI:10.25504/FAIRsharing.e5y0j0
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ready Clinical Knowledgebase

Abbreviation:JAX-CKB

General Information
The Jackson Laboratory Clinical Knowledgebase (CKB) is a semi-automated/manually curated database of gene/variant annotations, therapy knowledge, diagnostic/prognostic information, and clinical trials related to oncology. CKB not only contains current information on the protein effect of somatic gene variants, but also connects the variant to targeted therapies through an efficacy evidence annotation. In addition, CKB captures clinical trial patient eligibility criteria that include genomic alterations (genotype-specific). The public access version of CKB encompasses 82 commonly known driver genes. Users can search CKB via gene, gene variants, drug, drug class, indication, and clinical trials. The web-based version of CKB is designed to interrogate the knowledgebase for specific data attributes while also enabling a robust browse like feature when the desired content is unknown.

Homepage https://jax.org/ckb

Countries that developed this resource United States

Created in 2014

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How to cite this record FAIRsharing.org: JAX-CKB; Clinical Knowledgebase; DOI: https://doi.org/10.25504/FAIRsharing.e5y0j0; Last edited: Jan. 8, 2019, 1:22 p.m.; Last accessed: Sep 18 2020 9 a.m.


This record is maintained by smockus  ORCID

Record added: June 14, 2016, 10:37 a.m.
Record updated: Oct. 1, 2018, 12:09 p.m. by smockus.

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support email ckbsupport@jax.org

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Contact Susan Mockus   ORCID

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Publications

The clinical trial landscape in oncology and connectivity of somatic mutational profiles to targeted therapies.

Patterson SE1, Liu R2, Statz CM3, Durkin D4, Lakshminarayana A5, Mockus SM6.
Hum Genomics 2016

View Paper (PubMed) View Publication

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