Target Central Resource Database

Abbreviation:TCRD

General Information

TCRD is the central resource behind the Illuminating the Druggable Genome Knowledge Management Center (IDG-KMC). TCRD contains information about human targets, with special emphasis on four families of targets that are central to the NIH IDG initiative: GPCRs, kinases, ion channels and nuclear receptors. Olfactory GPCRs (oGPCRs) are treated as a separate family. A key aim of the KMC is to classify the development/druggability level of targets. The official public portal for TCRD is Pharos (pharos.nih.gov). Based on modern web design principles the Pharos interface provides facile access to all data types collected by the KMC. Given the complexity of the data surrounding any target, efficient and intuitive visualization has been a high priority, to enable users to quickly navigate & summarize search results and rapidly identify patterns. A critical feature of the interface is the ability to perform flexible search and subsequent drill down of search results. Underlying the interface is a RESTful API that provides programmatic access to all KMC data, allowing for easy consumption in user applications.

Homepage http://juniper.health.unm.edu/tcrd/

Developed in United States

Created in 2013

Taxonomic range

Scope and data types

Gene-disease association

Life Science

Molecular interaction

How to cite this record FAIRsharing.org: TCRD; Target Central Resource Database; DOI: https://doi.org/10.25504/FAIRsharing.1gn47b; Last edited: Feb. 22, 2018, 3:02 p.m.; Last accessed: Sep 22 2018 9:18 p.m.

This record is maintained by rguha and Tudorzinho ORCID

Record added: Nov. 4, 2016, 5:29 p.m.
Record updated: Jan. 12, 2018, 2:33 p.m. by The FAIRsharing Team.

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Edits to 'https://fairsharing.org/FAIRsharing.1gn47b' by 'The FAIRsharing Team' at 10:37, 23 Nov 2016 (approved):

	'description' has been modified:
		Before: TCRD is the central resource behind the Illuminating the Druggable Genome Knowledge Management Center (IDG-KMC). TCRD contains information about human targets, with special emphasis on four families of targets that are central to the NIH IDG initiative: GPCRs, kinases, ion channels and nuclear receptors. Olfactory GPCRs (oGPCRs) are treated as a separate family. A key aim of the KMC is to classify the development/druggability level of targets. The official public portal for TCRD is Pharos (pharos.nih.gov). 
		After: TCRD is the central resource behind the Illuminating the Druggable Genome Knowledge Management Center (IDG-KMC). TCRD contains information about human targets, with special emphasis on four families of targets that are central to the NIH IDG initiative: GPCRs, kinases, ion channels and nuclear receptors. Olfactory GPCRs (oGPCRs) are treated as a separate family. A key aim of the KMC is to classify the development/druggability level of targets. The official public portal for TCRD is Pharos (pharos.nih.gov). Based on modern web design principles the Pharos interface provides facile access to all data types collected by the KMC. Given the complexity of the data surrounding any target, efficient and intuitive visualization has been a high priority, to enable users to quickly navigate & summarize search results and rapidly identify patterns. A critical feature of the interface is the ability to perform flexible search and subsequent drill down of search results. Underlying the interface is a RESTful API that provides programmatic access to all KMC data, allowing for easy consumption in user applications.

Support

General

FAQ	https://pharos.nih.gov/idg/faq
support email	pharos@mail.nih.gov
schema file	http://juniper.health.unm.edu/tcrd/downl ...

Additional Information

Contact

Tudor Oprea ORCID

Tools

Pharos: UI for the Illuminating the Druggable Genome (IDG) program

http://pharos.nih.gov/

Access / Retrieve Data

Conditions of Use

Applies to: Data use

Creative Commons Attribution-ShareAlike 4.0 International (CC BY-SA 4.0)

REST Web Services

Only GET requests are currently supported. http://juniper.health.unm.edu/tcrd/api/_info will return a brief description of the API some info on the version of the database being accessed.	http://juniper.health.unm.edu/tcrd/api.html
Entry point to entity-specific APIs	https://pharos.nih.gov/idg/api/v1

Publications

Pharos: Collating protein information to shed light on the druggable genome.

Nguyen DT,Mathias S,Bologa C,Brunak S,Fernandez N,Gaulton A,Hersey A,Holmes J,Jensen LJ,Karlsson A,Liu G,Ma'ayan A,Mandava G,Mani S,Mehta S,Overington J,Patel J,Rouillard AD,Schurer S,Sheils T,Simeonov A,Sklar LA,Southall N,Ursu O,Vidovic D,Waller A,Yang J,Jadhav A,Oprea TI,Guha R
Nucleic Acids Res 2016

View Paper (PubMed) View Publication

Related Standards

Reporting Guidelines

No guidelines defined

Terminology Artifacts

Models and Formats

No syntax standards defined

Related Databases

Implementing Policies

This record is not implemented by any policy.

Credit

Record Maintainer

This record is maintained by rguha and Tudorzinho ORCID

Funds

National Center for Advancing Translational Sciences (Research institute)
NIH Common Fund (Government body)
Novo Nordisk Foundation Center for Protein Research (Research institute)

Maintains

European Commission under FP7 Grant Agreement (Government body)
Icahn School of Medicine at Mount Sinai (Research institute)
UNM School of Medicine (University)
University of Miami School of Medicine, USA (University)

Grant Number(s)

1U54CA189201-01 (NIH Common Fund)
1U54CA189205-01 (NIH Common Fund)
5U54CA189205-02 (NIH Common Fund)
NNF14CC0001 (Novo Nordisk Foundation Center for Protein Research)

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