The MalaCards human disease database (http://www.
malacards.org/) is an integrated compendium of annotated
diseases mined from 68 data sources. MalaCards
has a web card for each of ∼20 000 disease
entries, in six global categories. It portrays
a broad array of annotation topics in 15 sections,
including Summaries, Symptoms, Anatomical Context,
Drugs, Genetic Tests, Variations and Publications.
The Aliases and Classifications section reflects
an algorithm for disease name integration
across often-conflicting sources, providing effective
annotation consolidation. A central feature is
a balanced Genes section, with scores reflecting
the strength of disease-gene associations. This is
accompanied by other gene-related disease information
such as pathways, mouse phenotypes and
GO-terms, stemming from MalaCards’ affiliation with
the GeneCards Suite of databases. MalaCards’ capacity
to inter-link information from complementary
sources, along with its elaborate search function,
relational database infrastructure and convenient
data dumps, allows it to tackle its rich disease annotation
landscape, and facilitates systems analyses
and genome sequence interpretation. MalaCards
adopts a ‘flat’ disease-card approach, but each card
is mapped to popular hierarchical ontologies (e.g.
International Classification of Diseases, Human Phenotype
Ontology and Unified Medical Language System)
and also contains information about multi-level
relations among diseases, thereby providing an optimal
tool for disease representation and scrutiny.
How to cite this record:
FAIRsharing.org: MalaCards; MalaCards; DOI: https://doi.org/10.25504/FAIRsharing.e4r5nj;
Last edited: Feb. 22, 2018, 3:02 p.m.; Last accessed: Apr 22 2018 1:06 p.m.
Record added: Dec. 5, 2016, 9:50 a.m.
Dec. 14, 2016, 10:14 a.m. by The FAIRsharing Team.