Databases > biodbcore-001010

ready Database of fuzzy protein complexes

Abbreviation:FuzDB

General Information
FuzDB compiles experimentally observed fuzzy protein complexes, where intrinsic disorder (ID) is maintained upon interacting with a partner (protein, nucleic acid or small molecule) and directly impacts biological function. Entries in the database have both (i) structural evidence demonstrating the structural multiplicity or dynamic disorder of the ID region(s) in the partner bound form of the protein and (ii) in vitro or in vivo biological evidence that indicates the significance of the fuzzy region(s) in the formation, function or regulation of the assembly. Unlike the other intrinsically disordered or unfolded protein databases, FuzDB focuses on ID regions within a biological context, including higher-order assemblies and presents a detailed analysis of the structural and functional data.

Homepage http://protdyn-database.org/

Developed in Hungary

Created in 2015

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This record is maintained by monikafuxreiter

Record added: Oct. 17, 2017, 2:39 p.m.
Record updated: Oct. 17, 2017, 2:39 p.m. by The FAIRsharing Team.


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Grant Number(s)

  • LP2012-41 (Momentum Program of the Hungarian Academy of Sciences)

  • NN 106562 (Hungarian Scientific Research Fund)


Publications

FuzDB: database of fuzzy complexes, a tool to develop stochastic structure-function relationships for protein complexes and higher-order assemblies.

Miskei M,Antal C,Fuxreiter M
Nucleic Acids Res 2016

View Paper (PubMed) View Paper (DOI)