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PROtein-protein compleX MutAtion ThErmodynamics Database

Abbreviation:PROXiMATE

General Information

PROXiMATE is a database of thermodynamic data for more than 6000 missense mutations in 174 heterodimeric protein-protein complexes, supplemented with interaction network data from STRING database, solvent accessibility, sequence, structural and functional information, experimental conditions and literature information. Additional features include complex structure visualization, search and display options, download options and a provision for users to upload their data.

Homepage http://www.iitm.ac.in/bioinfo/PROXiMATE/index.html

Countries that developed this resource India

Created in 2016

Taxonomic range

All

Knowledge Domains

Subjects

Awaiting DOI assignment.

Publication for citation PROXiMATE: a database of mutant protein-protein complex thermodynamics and kinetics. Jemimah S,Yugandhar K,Michael Gromiha M; Bioinformatics ; 2017; 10.1093/bioinformatics/btx312;

Record added: Aug. 8, 2018, 11:17 a.m.
Record updated: Feb. 4, 2021, 1:40 p.m. by The FAIRsharing Team.

Show edit history

Edits to 'https://fairsharing.org/bsg-d001144' by 'The FAIRsharing Team' at 13:40, 04 Feb 2021 (approved):

	'onto_disciplines' has been modified:
		Before:
			Life Science
			Thermodynamics
		After:
			Biology
			Thermodynamics
		Added:
			Biology
		Removed:
			Life Science

	'dataProcesses' has been modified:
		Before:
			search, data access, https://www.iitm.ac.in/bioinfo/cgi-bin/PROXiMATE/search.py
			browse, data access, https://www.iitm.ac.in/bioinfo/cgi-bin/PROXiMATE/wild.py
			upload, data curation, https://www.iitm.ac.in/bioinfo/cgi-bin/PROXiMATE/upload.py
		After:
			search, data access, https://www.iitm.ac.in/bioinfo/cgi-bin/PROXiMATE/search.py
			browse, data access, https://www.iitm.ac.in/bioinfo/cgi-bin/PROXiMATE/wild.py
			upload, data curation, https://www.iitm.ac.in/bioinfo/cgi-bin/PROXiMATE/upload.py
			Download (by request), data release, https://www.iitm.ac.in/bioinfo/cgi-bin/PROXiMATE/download.py
		Added:
			Download (by request), data release, https://www.iitm.ac.in/bioinfo/cgi-bin/PROXiMATE/download.py
		Removed:

	'onto_domains' has been modified:
		Before:
			Pathway or network prediction
			Protein interactions
			mutation
		After:
			Prediction and recognition
			Protein interactions
			Protein structure
			Protein-Protein Interaction
			Structure
			mutation
			protein-containing complex
			structure
		Added:
			Prediction and recognition
			Protein structure
			Protein-Protein Interaction
			Structure
			protein-containing complex
			structure
		Removed:
			Pathway or network prediction

Edits to 'https://fairsharing.org/bsg-d001144' by 'The FAIRsharing Team' at 10:23, 17 Jan 2020 (approved):

	'related_databases' has been modified:
		Before:
			STRING
			Worldwide Protein Data Bank
		After:
			STRING
			UniProt Knowledgebase
			Worldwide Protein Data Bank
		Added:
			UniProt Knowledgebase
		Removed:

Edits to 'https://fairsharing.org/bsg-d001144' by 'The FAIRsharing Team' at 17:27, 29 Aug 2018 (approved):

	'contactORCID' has been modified:
		Before: https://orcid.org/0000-0002-1776-4096
		After: 0000-0002-1776-4096

Support

General

FAQ	FAQ
online documentation	Tutorial

Additional Information

Contact

Michael Gromiha ORCID

Tools

No tools defined

Access / Retrieve Data

Conditions of Use

Applies to: Data use

PROXiMATE Disclaimer

Data Release

Download (by request)

https://www.iitm.ac.in/bioinfo/cgi-bin/PROXiMATE/download.py

Data Curation

upload

https://www.iitm.ac.in/bioinfo/cgi-bin/PROXiMATE/upload.py

Data Access

search	https://www.iitm.ac.in/bioinfo/cgi-bin/PROXiMATE/search.py
browse	https://www.iitm.ac.in/bioinfo/cgi-bin/PROXiMATE/wild.py

Publications

PROXiMATE: a database of mutant protein-protein complex thermodynamics and kinetics.

Jemimah S,Yugandhar K,Michael Gromiha M
Bioinformatics 2017

View Paper (PubMed) View Publication

Related Standards

Reporting Guidelines

No guidelines defined

Terminology Artifacts

No semantic standards defined

Models and Formats

No syntax standards defined

Identifier Schemas

No identifier schema standards defined

Metrics

No metrics standards defined

Related Databases

Implementing Policies

This record is not implemented by any policy.

Credit

Record Maintainer

This record is in need of a maintainer. If you login, you'll be able to claim this record.

Funds

Ministry of Human Resource and Development, India (Government body)
Department of Science and Technology, Government of India (Government body)

PROtein-protein compleX MutAtion ThErmodynamics Database

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