databases > bsg-d001479

in development Chromium Epigenomics Toxicology

Abbreviation:EpiCrDB

General Information
Hexavalent chromium [Cr(VI)] compounds are well-established respiratory carcinogens utilized in industrial processes. While inhalation exposure constitutes an occupational risk affecting mostly chromium workers, environmental exposure from drinking water contamination is a widespread gastrointestinal carcinogen, affecting millions of people throughout the world. The mechanism of action of Cr(VI) at the molecular level is poorly understood. In Chromium Epigenomics Toxicology, we have used a variety of epigenomics experimental assays to demonstrate that Cr(VI) perturbs chromatin organization and dynamics, and thus at least some of its toxicity can be attributed to epigenetic carcinogenicity. We include manually annotated sample and experiment metadata to facilitate FAIR data access.




Awaiting DOI assignment.

Publication for citation  Chromium disrupts chromatin organization and CTCF access to its cognate sites in promoters of differentially expressed genes. VonHandorf A,Sanchez-Martin FJ,Biesiada J,Zhang H,Zhang X,Medvedovic M,Puga A; Epigenetics ; 2018; 10.1080/15592294.2018.1454243;


This record is maintained by apChromium  ORCID

Record added: May 4, 2020, 3:14 p.m.
Record updated: May 6, 2020, 10:13 a.m. by The FAIRsharing Team.



Support

No support information provided.

Additional Information


Tools

    No tools defined




Publications

Chromium disrupts chromatin organization and CTCF access to its cognate sites in promoters of differentially expressed genes.

VonHandorf A,Sanchez-Martin FJ,Biesiada J,Zhang H,Zhang X,Medvedovic M,Puga A
Epigenetics 2018

View Paper (PubMed) View Publication

Formaldehyde-Assisted Isolation of Regulatory Elements (FAIRE) analysis uncovers broad changes in chromatin structure resulting from hexavalent chromium exposure.

Ovesen JL,Fan Y,Zhang X,Chen J,Medvedovic M,Xia Y,Puga A
PLoS One 2014

View Paper (PubMed) View Publication

Highlight Article: Chromium exposure disrupts chromatin architecture upsetting the mechanisms that regulate transcription.

Zablon HA,VonHandorf A,Puga A
Exp Biol Med (Maywood) 2019

View Paper (PubMed) View Publication

Related Standards

Reporting Guidelines

No guidelines defined

Terminology Artifacts

No semantic standards defined

Models and Formats

No syntax standards defined

Identifier Schemas

No identifier schema standards defined

Metrics

No metrics standards defined


Related Databases

No related databases defined


Implementing Policies

This record is not implemented by any policy.


Credit

Record Maintainer

Maintains