Standards > terminology artifact > bsg-s000061


ready Mosquito Insecticide Resistance Ontology

Abbreviation:MIRO


General Information
Monitoring of insect vector populations with respect to their susceptibility to one or more insecticides is a crucial element of the strategies used for the control of arthropod-borne diseases. This management task can nowadays be achieved more efficiently when assisted by IT (Information Technology) tools, ranging from modern integrated databases to GIS (Geographic Information System). MIRO is an application ontology that can be used for the purpose of controlling mosquitoes and, thus, the diseases that they transmit.


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Record updated: Nov. 22, 2016, 10:20 a.m. by The FAIRsharing Team.


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MIRO Ontology Display

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Implementing Databases (11)
IntAct molecular interaction database
IntAct provides a freely available, open source database system and analysis tools for protein interaction data. All interactions are derived from literature curation or direct user submissions and are freely available.

STRING: functional protein association networks
STRING is a database of known and predicted protein interactions. The interactions include direct (physical) and indirect (functional) associations.

VirHostNet
VirHostNet integrates an extensive and original literature-curated dataset of virus_virus and virus_host interactions (2671 non-redundant interactions) representing more than 180 distinct viral species and one of the largest human interactome (10 672 proteins and 68 252 non-redundant interactions) reconstructed from publicly available data.

Human Protein Reference Database
The Human Protein Reference Database represents a centralized platform to visually depict and integrate information pertaining to domain architecture, post-translational modifications, interaction networks and disease association for each protein in the human proteome.

Microbial Protein Interaction Database
The microbial protein interaction database (MPIDB) provides physical microbial interaction data. The interactions are manually curated from the literature or imported from other databases, and are linked to supporting experimental evidence, as well as evidences based on interaction conservation, protein complex membership, and 3D domain contacts.

Biological General Repository for Interaction Datasets
BioGRID is an interaction repository with data compiled through comprehensive curation efforts. BioGRID currently holds over 980,000 interactions curated from both high-throughput datasets and individual focused studies, as derived from over 55,000 publications in the primary literature. Complete coverage of the entire literature is maintained for budding year (S. cerevisiae), fission yeast (S. pome), and thale cress (A. thaliana), and efforts to expand curation across multiple metazoan species are underway. All data are freely provided via the search index and available for download in standardized formats.

InnateDB
InnateDB has been developed to facilitate systems level investigations of the mammalian (human, mouse and bovine) innate immune response. Its goal is to provide a manually-curated knowledgebase of the genes, proteins, and particularly, the interactions and signaling responses involved in mammalian innate immunity. InnateDB incorporates information of the whole human, mouse and bovine interactomes by integrating interaction and pathway information from several of the major publicly available databases but aims to capture an improved coverage of the innate immunity interactome through manual curation.

Interaction Reference Index Web Interface
iRefWeb is an interface to a relational database containing the latest build of the interaction Reference Index (iRefIndex) which integrates protein interaction data from ten different interaction databases: BioGRID, BIND, CORUM, DIP, HPRD, INTACT, MINT, MPPI, MPACT and OPHID.

Database of Interacting Proteins
The database of interacting protein (DIP) database stores experimentally determined interactions between proteins. It combines information from a variety of sources to create a single, consistent set of protein-protein interactions

Interologous Interaction Database
Experimentally-determined interactions and signaling pathways involved in the innate immune response of humans, mice and bovines to microbial infection

VectorBase
VectorBase is a web-accessible data repository for information about invertebrate vectors of human pathogens. VectorBase annotates and maintains vector genomes providing an integrated resource for the research community. Currently, VectorBase contains genome information for 38 organisms including Anopheles gambiae, a vector for the Plasmodium protozoan agent causing malaria, and Aedes aegypti, a vector for the flaviviral agents causing Yellow fever and Dengue fever. Recent additions include large scale variant (SNP) datasets and population genetics data (genotype/phenotype).

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Grant Number(s)

  • HHSN266200400039C (National Institute of Allergy and Infectious Diseases)

  • LSHP-CT-2004-503578 (European Commission FP6)


Publications

MIRO and IRbase: IT tools for the epidemiological monitoring of insecticide resistance in mosquito disease vectors.

Dialynas E,Topalis P,Vontas J,Louis C
PLoS Negl Trop Dis 2009

View Paper (PubMed) View Paper (DOI)