Standards > terminology artifact > bsg-s000139

ready PRotein Ontology


General Information
Protein Ontology (PRO) provides an ontological representation of protein-related entities by explicitly defining them and showing the relationships between them. Each PRO term represents a distinct class of entities (including specific modified forms, orthologous isoforms, and protein complexes) ranging from the taxon-neutral to the taxon-specific. The ontology has a meta-structure encompassing three areas: proteins based on evolutionary relatedness (ProEvo); protein forms produced from a given gene locus (ProForm); and protein-containing complexes (ProComp).

How to cite this record; DOI:; Last edited: Feb. 22, 2018, 2:41 p.m.; Last accessed: Feb 23 2018 1:51 p.m.


Developed in United States

Created in 2006

Taxonomic range

Scope and data types

This record is maintained by dnatale

Record updated: Nov. 29, 2016, 9:56 p.m. by The FAIRsharing Team.


    No tools defined


No XSD schemas defined


The representation of protein complexes in the Protein Ontology (PRO).

Bult CJ,Drabkin HJ,Evsikov A,Natale D,Arighi C,Roberts N,Ruttenberg A,D'Eustachio P,Smith B,Blake JA,Wu C
BMC Bioinformatics 2011

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Framework for a protein ontology.

Natale DA,Arighi CN,Barker WC,Blake J,Chang TC,Hu Z,Liu H,Smith B,Wu CH
BMC Bioinformatics 2007

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The Protein Ontology: a structured representation of protein forms and complexes.

Natale DA,Arighi CN,Barker WC,Blake JA,Bult CJ,Caudy M,Drabkin HJ,D'Eustachio P,Evsikov AV,Huang H,Nchoutmboube J,Roberts NV,Smith B,Zhang J,Wu CH
Nucleic Acids Res 2011

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Protein Ontology: a controlled structured network of protein entities.

Natale DA,Arighi CN,Blake JA,Bult CJ,Christie KR,Cowart J,D'Eustachio P,Diehl AD,Drabkin HJ,Helfer O,Huang H,Masci AM,Ren J,Roberts NV,Ross K,Ruttenberg A,Shamovsky V,Smith B,Yerramalla MS,Zhang J,AlJanahi A,Celen I,Gan C,Lv M,Schuster-Lezell E,Wu CH
Nucleic Acids Res 2014

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PR Ontology Display

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Disclaimer: This widget assumes the availability of the ontology resources in the NCBO BioPortal.

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Related Standards

Reporting Guidelines

No guidelines defined

Models and Formats

No syntax standards defined

Implementing Databases (2)
UniProt Knowledgebase
The UniProt Knowledgebase (UniProtKB) is the central hub for the collection of functional information on proteins, with accurate, consistent and rich annotation. In addition to capturing the core data mandatory for each UniProtKB entry (mainly, the amino acid sequence, protein name or description, taxonomic data and citation information), as much annotation information as possible is added. This includes widely accepted biological ontologies, classifications and cross-references, and clear indications of the quality of annotation in the form of evidence attribution of experimental and computational data. The UniProt Knowledgebase consists of two sections: a reviewed section containing manually-annotated records with information extracted from literature and curator-evaluated computational analysis (aka "UniProtKB/Swiss-Prot"), and an unreviewed section with computationally analyzed records that await full manual annotation (aka "UniProtKB/TrEMBL").

Immunology Database and Analysis Portal
The ImmPort system serves as a long-term, sustainable archive of immunology research data generated by investigators mainly funded through the NIAID/DAIT. The core component of the ImmPort system is an extensive data warehouse containing an integration of experimental data and clinical trial data. The analytical tools created and integrated as part of the ImmPort system are available to any researcher within ImmPort after registration and approval by DAIT. Additionally, the data provided mainly by NIAID/DAIT funded researchers in ImmPort will be available to all registered users after the appropriate embargo time. ImmPort, is the data submission portal where researchers upload, QC, and curate their data prior to sharing in OpenImmPort.

Implementing Policies

This record is not implemented by any policy.


Record Maintainer

  • This record is maintained by dnatale



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