Standards > terminology artifact > bsg-s000955

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ready Drug Target Ontology

Abbreviation:DTO


General Information
Drug Target Ontology (TDO) is developed as a reference for drug targets with the longer-term goal to create a community standard that will facilitate the integration of diverse drug discovery information from numerous heterogeneous resources. The first version of the DTO consists of asserted class hierarchies of the four IDG protein families, GPCRs, kinases, ion channels, and nuclear hormone receptors. Protein classes are linked to tissue and disease via different levels of confidence. DTO also contains drug target development classifications, a large collection of cell lines from the LINCS project and relevant cell-disease and cell-tissue relations. DTO is modeled in OWL2-DL to enable further classification by inference reasoning and SPARQL queries. DTO is implemented following a modularization approach. DTO will serve as the organizational framework for drug targets in the IDG PHAROS User Interface Portal (https://pharos.nih.gov).



Record added: Oct. 24, 2017, 9:41 a.m.
Record updated: Jan. 16, 2018, 11:28 a.m. by The FAIRsharing Team.


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General

Additional Information

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Tools

    No tools defined


Schemas

No XSD schemas defined


Access / Retrieve Data

Conditions of Use

Applies to: Data use

Data Access




Connectivity
DTO Ontology Display

View in BioPortal.


Disclaimer: This widget assumes the availability of the ontology resources in the NCBO BioPortal.


Related Standards

Reporting Guidelines

No guidelines defined

Terminology Artifacts

No semantic standards defined

Models and Formats


Implementing Databases (1)
Target Central Resource Database
TCRD is the central resource behind the Illuminating the Druggable Genome Knowledge Management Center (IDG-KMC). TCRD contains information about human targets, with special emphasis on four families of targets that are central to the NIH IDG initiative: GPCRs, kinases, ion channels and nuclear receptors. Olfactory GPCRs (oGPCRs) are treated as a separate family. A key aim of the KMC is to classify the development/druggability level of targets. The official public portal for TCRD is Pharos (pharos.nih.gov). Based on modern web design principles the Pharos interface provides facile access to all data types collected by the KMC. Given the complexity of the data surrounding any target, efficient and intuitive visualization has been a high priority, to enable users to quickly navigate & summarize search results and rapidly identify patterns. A critical feature of the interface is the ability to perform flexible search and subsequent drill down of search results. Underlying the interface is a RESTful API that provides programmatic access to all KMC data, allowing for easy consumption in user applications.

Implementing Policies

This record is not implemented by any policy.


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Publications

Drug target ontology to classify and integrate drug discovery data.

Lin Y,Mehta S,Kucuk-McGinty H,Turner JP,Vidovic D,Forlin M,Koleti A,Nguyen DT,Jensen LJ,Guha R,Mathias SL,Ursu O,Stathias V,Duan J,Nabizadeh N,Chung C,Mader C,Visser U,Yang JJ,Bologa CG,Oprea TI,Schurer SC
J Biomed Semantics 2017

View Paper (PubMed) View Paper (DOI)