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Drug Target Ontology
No XSD schemas defined
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Models and Formats
TCRD is the central resource behind the Illuminating the Druggable Genome Knowledge Management Center (IDG-KMC). TCRD contains information about human targets, with special emphasis on four families of targets that are central to the NIH IDG initiative: GPCRs, kinases, ion channels and nuclear receptors. Olfactory GPCRs (oGPCRs) are treated as a separate family. A key aim of the KMC is to classify the development/druggability level of targets. The official public portal for TCRD is Pharos (pharos.nih.gov). Based on modern web design principles the Pharos interface provides facile access to all data types collected by the KMC. Given the complexity of the data surrounding any target, efficient and intuitive visualization has been a high priority, to enable users to quickly navigate & summarize search results and rapidly identify patterns. A critical feature of the interface is the ability to perform flexible search and subsequent drill down of search results. Underlying the interface is a RESTful API that provides programmatic access to all KMC data, allowing for easy consumption in user applications.
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U54CA189205 (Illuminating the Druggable Genome Knowledge Management Center, Tudor Oprea, PI) (NIH Common Fund, USA)
Drug target ontology to classify and integrate drug discovery data.
Lin Y,Mehta S,Kucuk-McGinty H,Turner JP,Vidovic D,Forlin M,Koleti A,Nguyen DT,Jensen LJ,Guha R,Mathias SL,Ursu O,Stathias V,Duan J,Nabizadeh N,Chung C,Mader C,Visser U,Yang JJ,Bologa CG,Oprea TI,Schurer SC
J Biomed Semantics 2017