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ready Hierarchical Editing Language for Macromolecules

Abbreviation: HELM

General Information
HELM (Hierarchical Editing Language for Macromolecules) enables the representation of a wide range of biomolecules (e.g. proteins, nucleotides, antibody drug conjugates) whose size and complexity render existing small-molecule and sequence-based informatics methodologies impractical or unusable. HELM solves this problem through a hierarchical notation that represents complex macromolecules as polymeric structures with support for unnatural components (e.g. unnatural amino acids) and chemical modifications.

How to cite this record HELM; Hierarchical Editing Language for Macromolecules; DOI:; Last edited: Jan. 8, 2019, 1:39 p.m.; Last accessed: Jan 17 2022 3:35 a.m.

This record is maintained by HELMInfo  (MacroMol)

Record added: July 18, 2018, 4:44 p.m.
Record updated: July 19, 2018, 1:16 p.m. by The FAIRsharing Team.

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Applies to: Database software


HELM: a hierarchical notation language for complex biomolecule structure representation.

Zhang T,Li H,Xi H,Stanton RV,Rotstein SH
J Chem Inf Model 2012

View Paper (PubMed) View Publication

HELM Software for Biopolymers.

Milton J,Zhang T,Bellamy C,Swayze E,Hart C,Weisser M,Hecht S,Rotstein S
J Chem Inf Model 2017

View Paper (PubMed) View Publication

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Related Databases (1)
PubChem is organized as three linked databases within the NCBI's Entrez information retrieval system. These are PubChem Substance, PubChem Compound, and PubChem BioAssay. PubChem also provides a fast chemical structure similarity search tool. More information about using each component database may be found using the links in the homepage.

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