standards > model/format > bsg-s001478
Did we miss something? Our COVID-19 Collection is growing, but not yet complete. Tell us what's missing. Email or add missing resources to our spreadsheet

ready CRAM

General Information
CRAM is a sequencing read file format that is highly space efficient by using reference-based compression of sequence data and offers both lossless and lossy modes of compression. Building on early proof-of-principle for reference-based compression (Hsi-Yang Fritz, et al. (2011). Genome Res. 21:734-740), the CRAM format balances usability with compression efficiency.

Awaiting DOI assignment.

Record added: May 22, 2020, 3:11 p.m.
Record updated: May 22, 2020, 3:27 p.m. by The FAIRsharing Team.

Show edit history



Additional Information


No XSD schemas defined

Access / Retrieve Data


Efficient storage of high throughput DNA sequencing data using reference-based compression.

Hsi-Yang Fritz M,Leinonen R,Cochrane G,Birney E
Genome Res 2011

View Paper (PubMed) View Publication

The Scramble conversion tool.

Bonfield JK
Bioinformatics 2014

View Paper (PubMed) View Publication

Related Standards

Reporting Guidelines

No guidelines defined

Terminology Artifacts

No semantic standards defined

Identifier Schemas

No identifier schema standards defined


No metrics standards defined

Related Databases (0)

No Related Databases

Implementing Policies

This record is not implemented by any policy.


Record Maintainer

  • This record is in need of a maintainer. If you login, you'll be able to claim this record.



Grant Number(s)

  • 085532 (The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge, UK)

  • 098051 (The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge, UK)