Clusters of Orthologous Groups (COG) Analysis Ontology
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Clusters of Orthologous Groups of proteins (COGs) were delineated by comparing protein sequences encoded in complete genomes, representing major phylogenetic lineages. Each COG consists of individual proteins or groups of paralogs from at least 3 lineages and thus corresponds to an ancient conserved domain.
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A genomic perspective on protein families.
Tatusov RL,Koonin EV,Lipman DJ