The LINCS project is based on the premise that disrupting any one of the many steps of a given biological process will cause related changes in the molecular and cellular characteristics, behavior, and/or function of the cell – the observable composite of which is known as the cellular phenotype. Observing how and when a cell’s phenotype is altered by specific stressors can provide clues about the underlying mechanisms involved in perturbation and ultimately, disease. In LINCS Production Phase II, the LINCS Data Working Group (DWG) is currently developing extended metadata specifications describing LINCS reagents, assays and experiments. Annotations for the perturbagens (small molecules, siRNA, growth factors and other ligands), cells, and some elements of experimental metadata should be common between all LINCS Centers. This will facilitate development of data analysis, formatting, and visualization strategies by LINCS investigators, and also the development of databases and data repositories in which to store and share LINCS data. This collection contains records for all LINCS resources associated with the project.

This record is maintained by: cchung   ORCID

Record added: April 27, 2016, 2:24 p.m..
Record updated: June 1, 2017, 12:09 p.m. by The FAIRsharing Team.

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